Zeynab Nezamdoust , Marziyeh Saghebjoo, Afson Barzgar,
Volume 14, Issue 2 (1-2015)
Abstract
Background: This study was conducted to determine the effect of 12 weeks of aerobic training on serum levels of vaspin and glucose homeostasis variables in patients with type 2 diabetes. Methods: In this quasi-experimental study, 20 women with type П diabetes (mean±SD: age 43.30 ±3.02 yr, body mass index 27.089±3.23 kg/m2 and body fat 29.46 ±2.71%) were randomized into experimental (n = 10) and control (n = 10) groups. Experimental group performed twelve weeks aerobic training (3 times per week at an intensity of 75-85 % of maximum heart rate reserve). Blood samples were collected 24h before and 48h after the training. Data was analyzed by paired and independent samples t-test (P <0.05). Results: Results showed a significant decrease in serum levels of vaspin, fasting blood sugar and insulin resistance index (P value 0.001, 0.01 and 0.007 respectively) ) in experimental group and body weight, body mass index, percent body fat and waist to hip ratio significantly decreased in experimental group (P value 0.002, 0.01, 0.04 and 0.03 respectively). Conclusion: The results of this study showed that aerobic training along with decrease in body weight and percent body fat leads to significant decrease in serum levels of vaspin, fasting glucose and insulin resistance index, so can be considered as a complementary therapy method in patients with type 2 diabetes.
Shahab Alizadeh, Khadijeh Mirzaei, Seyed Ali Keshavarz,
Volume 16, Issue 6 (10-2017)
Abstract
Background: The adipokines omentin-1, vaspin, and retinol binding protein-4 (RBP-4) are mediators of body composition and adipose tissue that contribute to metabolic changes caused by obesity. The aim of this study was to determine the association between serum levels of these adipokines with body composition indices and metabolic status in different phenotypes of body size.
Methods: In the present cross-sectional study, a total of 350 women, including 127 metabolically healthy (MH) subjects and 223 metabolically unhealthy (MUH) subjects participated. The subjects were considered as MH in the presence of at least 4 of the five following metabolic indices: TG ≤ 1.70 mmol/L, LDL-C≤ 2.60 mmol /L, TC≤ 5.20 mmol /L, HDL-C≥1.30, and HOMA-IR≤ 1.95; otherwise subjects were considered as MUH.
Results: The results showed that serum levels of omentin-1 have a significant positive association with MHS (OR = 1.04, p <0.0001). Even after controlling the confounding factors of age, sex and weight, this relationship was still significant. Plasma levels of vaspin and RBP-4 were not significantly related to MHS. Furthermore, there was a significant correlation between omentin-1 and body mass index (r = 0.31, p = 0.02) and body fat percentage (r = 0.32, P = 0.02) in MH subjects. In the healthy group, serum levels of RBP-4 were positively correlated with fat percentage (r = 0.68, p <0.0001) and body fat mass (r = 0.74, P <0.0001) and were negatively correlated with fat-free mass (r = -0.74, P <0.0001) and total body water (r = -0.76, P <0.0001). There was no statistically significant correlation between serum vaspin levels and body composition indices in both groups.
Conclusion: Serum levels of adipokines may be an appropriate predictor for metabolically healthy status. Further studies in this field can reveal possible mechanisms.
