Zeynab Nezamdoust , Marziyeh Saghebjoo, Afson Barzgar,
Volume 14, Issue 2 (1-2015)
Abstract
Background: This study was conducted to determine the effect of 12 weeks of aerobic training on serum levels of vaspin and glucose homeostasis variables in patients with type 2 diabetes. Methods: In this quasi-experimental study, 20 women with type П diabetes (mean±SD: age 43.30 ±3.02 yr, body mass index 27.089±3.23 kg/m2 and body fat 29.46 ±2.71%) were randomized into experimental (n = 10) and control (n = 10) groups. Experimental group performed twelve weeks aerobic training (3 times per week at an intensity of 75-85 % of maximum heart rate reserve). Blood samples were collected 24h before and 48h after the training. Data was analyzed by paired and independent samples t-test (P <0.05). Results: Results showed a significant decrease in serum levels of vaspin, fasting blood sugar and insulin resistance index (P value 0.001, 0.01 and 0.007 respectively) ) in experimental group and body weight, body mass index, percent body fat and waist to hip ratio significantly decreased in experimental group (P value 0.002, 0.01, 0.04 and 0.03 respectively). Conclusion: The results of this study showed that aerobic training along with decrease in body weight and percent body fat leads to significant decrease in serum levels of vaspin, fasting glucose and insulin resistance index, so can be considered as a complementary therapy method in patients with type 2 diabetes.
Shahab Alizadeh, Khadijeh Mirzaei, Seyed Ali Keshavarz,
Volume 16, Issue 6 (10-2017)
Abstract
Background: The adipokines omentin-1, vaspin, and retinol binding protein-4 (RBP-4) are mediators of body composition and adipose tissue that contribute to metabolic changes caused by obesity. The aim of this study was to determine the association between serum levels of these adipokines with body composition indices and metabolic status in different phenotypes of body size.
Methods: In the present cross-sectional study, a total of 350 women, including 127 metabolically healthy (MH) subjects and 223 metabolically unhealthy (MUH) subjects participated. The subjects were considered as MH in the presence of at least 4 of the five following metabolic indices: TG ≤ 1.70 mmol/L, LDL-C≤ 2.60 mmol /L, TC≤ 5.20 mmol /L, HDL-C≥1.30, and HOMA-IR≤ 1.95; otherwise subjects were considered as MUH.
Results: The results showed that serum levels of omentin-1 have a significant positive association with MHS (OR = 1.04, p <0.0001). Even after controlling the confounding factors of age, sex and weight, this relationship was still significant. Plasma levels of vaspin and RBP-4 were not significantly related to MHS. Furthermore, there was a significant correlation between omentin-1 and body mass index (r = 0.31, p = 0.02) and body fat percentage (r = 0.32, P = 0.02) in MH subjects. In the healthy group, serum levels of RBP-4 were positively correlated with fat percentage (r = 0.68, p <0.0001) and body fat mass (r = 0.74, P <0.0001) and were negatively correlated with fat-free mass (r = -0.74, P <0.0001) and total body water (r = -0.76, P <0.0001). There was no statistically significant correlation between serum vaspin levels and body composition indices in both groups.
Conclusion: Serum levels of adipokines may be an appropriate predictor for metabolically healthy status. Further studies in this field can reveal possible mechanisms.
Omid Zafarmand, Rahman Soori,
Volume 25, Issue 4 (9-2025)
Abstract
Background: Exercise training represents an effective approach that contributes substantially to lowering chemerin and vaspin levels, enhancing body composition, and preventing complications related to overweight and obesity. In this context, the present study sought to examine the effects of exercise training on chemerin, vaspin, and body composition in individuals with type 2 diabetes.
Methods: A systematic review and meta-analysis was conducted to evaluate the effects of exercise interventions on various outcomes in patients with type 2 diabetes. A comprehensive search for English and Persian articles published up to )January 4, 2025( was performed across the following databases: PubMed, Web of Science, Scopus, Google Scholar, IranDoc, Magiran, Noormags, and SID (Scientific Information Database). Fifteen studies, including 19 exercise interventions and 440 participants with type 2 diabetes, were included. Data were analyzed using a random-effects model, and the mean differences with 95% confidence intervals (CI) were calculated. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated through visual inspection of funnel plots and Egger’s test.
Results: A total of 15 studies (with 19 exercise interventions) involving 440 participants with type 2 diabetes were included in the meta-analysis. The results indicated that exercise interventions led to non-significant changes in c-Merlin [SMD= −0.967, 95% CI: −2.453 to 0.518, P= 0.202], body mass index (BMI) [SMD= −0.228, 95% CI: −0.470 to 0.013, P= 0.064], waist-to-hip ratio (WHR) [SMD= −0.038, 95% CI: −0.773 to 0.007, P= 0.054], and body fat percentage [SMD= 0.080, 95% CI: −0.524 to 0.685, P= 0.795] compared with the control group in individuals with type 2 diabetes.
Conclusion: The results of the present study demonstrated that exercise training significantly reduces vaspin levels in patients with type 2 diabetes, while it has no significant effect on chemerin, body composition, or body composition indices (including body mass index, body fat percentage, and waist-to-hip ratio). It appears that physical exercise may play an effective role in improving the metabolic status of patients with type 2 diabetes through the modulation of vaspin levels.
