Showing 8 results for Visfatin
Zahra Jamshidi Khezerlou, Sajad Ahmadizad, Mehdi Hedayati, Hiwa Rahmani, Azade Movahedi,
Volume 13, Issue 4 (5-2014)
Abstract
Background: The aim of this study was to compare responses of Visfatin and insulin resistance index to various resistance exercise protocols.
Methods: Ten healthy male subjects performed three resistance exercise protocols including maximal strength (three sets of 5 repetition at 85% of 1-RM with 3-min rest between sets), hyperthrophy (three sets of 10 repetition at 70% of 1-RM with 2-min rest between sets) and strength-endurance (three sets of 15 repetition at 55% of 1-RM with 1-min rest between sets) in three separate sessions. Two blood samples were taken before and after resistance exercise protocol. Responses to different resistance exercise protocols were compared by using repeated measures of ANOVA (3×2).
Results: Irrespective of resistance exercise protocol, results showed that plasma visfatin reduced significantly (P<0.05) in response to resistance exercise. Between group comparisons revealed that reductions in visfatin concentration in response to strength-endurance and hypertrophy protocols were significantly higher than maximal strength protocol (P<0.05). Analysis showed that not only glucose, insulin and insulin resistance index did not change in response to resistance exercise significantly, but also there was no significant difference among the responses to different resistance exercise protocols (P>0.05). In addition, there was no significant relationship between changes in visfatin and other parameters (P>0.05).
Conclusion: It could be concluded that performing strength-endurance and hypertrophy protocols that cause reductions in visfatin, possibly due to changes in growth hormone during these protocols, could be beneficial in reducing the hyperinsulinemia.
Hamed Rezaei Nasab, Roohollah Ranjbar, Abdol Hamid Habibi, Saeed Shakerian,
Volume 14, Issue 2 (1-2015)
Abstract
Background: The purpose of this study was to compare three intensities of acute aerobic exercise on plasma visfatin concentration in type 2 diabetic males. Methods: Ten men with type 2 diabetes (mean ± SD age 52.6 ± 3.6 years, height 171.3 ± 6.7 cm, Weight 87.58 ± 4.7 kg) participated in the study. In the first session, anthropometric measurements, body composition, and peak oxygen uptake (VO2peak) was measured in all subjects. In the next sessions, subjects completed three acute aerobic exercises on separate days in a crossover design. The three exercise trials performed at intensity of 40%, 60%, and 80% VO2peak after fasting for at least 10 hours. Energy expenditure was 300 kcal for each exercise trial. Blood samples before exercise, immediately after and 24 hours after exercise were collected for measuring visfatin, glucose and insulin. Results: The results showed no significance interaction (p>0.05) between exercise and sampling time. This analysis also revealed significance in the main effects (p>0.05) of the two factors (exercise and sampling time). Pearson correlation showed that there was significant relationship between visfatin and insulin (p<0.05). Conclusion: According to the present results, we can conclude that acute aerobic exercise at different intensities with 300 kcal energy expenditure will not change visfatin levels in type 2 diabetes.
Rozita Fathi, Sajjad Aslani Moghanjoughi, Elahe Talebi Garakani, Alireza Safarzadeh, Hassan Seyghal,
Volume 14, Issue 6 (9-2015)
Abstract
Background: Visfatin is an adipokine secreted from visceral adipose tissue and involved in glucose homeostasis. The aim of the present study was to investigate the effect of eight-week resistance training on plasma visfatin levels and its relation to insulin resistance in insulin-resistant male rats.
Methods: In this experimental study twenty-four Wistar male rats (220±20 gr) were acclimatized with lab condition then were randomly divided into three groups: Control (C), Insulin-Resistant control (IRC) and Insulin-resistant Training (T) groups. Insulin-resistance status induced by %10 fructose solution during 5 weeks. Resistance training group subjected to a three-day per week resistance training program for 8 weeks. Plasma visfatin, insulin, glucose levels, and insulin resistance index were assessed 48 hours after experimental period. Data were analyzed using one-way ANOVA and statistical significance was set at P<0/05
Results: The results showed that insulin resistance induction significantly increased plasma visfatin, glucose, insulin levels and insulin resistance index (P<0.05). On the other hand, resistance training significantly decreased plasma visfatin, glucose, and insulin levels (P<0.05) but visfatin was not altered significantly (P<0.05).
Conclusion: Based on the findings, visfatin increases in diabetes and insulin resistance and is correlated with insulin resistance. The change in plasma visfatin levels was not significant following resistance training and it was not correlated with insulin resistance index. Therefore, visfatin may not have a role in metabolic improvement induced by exercise training.
Mehdi Zarei, Mohamadreza Hamedinia, Amirhossein Haghighi, Raha Noorafshar, Sara Amini,
Volume 16, Issue 1 (1-2017)
Abstract
Background: The purpose of this study was to compare effects of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and Visfatin levels in men with type 2 diabetes.
Methods: 43 male patients with type 2 diabetes were randomly divided into 4 groups (three combined aerobic-resistance exercise training groups 1, 2, 3 and control). Training groups performed combined aerobic-resistance exercises for 12weeks, 3 times a week with given intensities )group 1:resistance 50-60% one repetition maximum- aerobic 70-80%maximum heart rate, group 2:resistance 60-70% one repetition maximum- aerobic 60-70% maximum heart rate and group 3:resistance 70-80% one repetition maximum- aerobic 50-60% maximum heart rate). Blood sampling to determine the levels of Visfatin, insulin, HbA1c, fasting glucose before and after 12weeks, were conducted.
Results: Visfatin levels and HbA1c in all training groups and fasting glucose in 2 combined training groups significantly decreased compared with control group (P<0.05). Vo2max was significantly increased in all training groups (P<0.05). No significant difference were observed between groups in body weight, Body mass index, fat mass, insulin levels and resistance insulin.
Conclusion: 12 weeks of combined aerobic-resistance exercise training protocols with were executed intensities through decreasing Visfatin and HbA1c levels and improving aerobic capacity could be helpful in patient with type 2diabetes. In addition to the above benefits, combined exercise training protocols of with intensity of 60-70% maximum heart rate–intensity 60-70% repetition maximum due to reducing fasting blood glucose could give greater benefits to patients.
Hamed Rezaei Nasab, Roohollah Ranjbar, Abdolhamid Habibi, Mohammad Taher Afshoon Pour,
Volume 17, Issue 1 (3-2018)
Abstract
visfatin secreted by various factors, including cytokines such as TNF-α and IL-6 is affected. The purpose of this study was to evaluate the effect of eight weeks of combined training (resistance circular - aerobic) visfatin concentration, IL-6 and TNF-α in obese men with type II diabetes.
Methods: The population of the research was all men with diabetes type II in District 2 of Ahwaz. Twenty four patients with diabetes type II, aged 40-55 years and fasting blood glucose lower than 200 mg /dl were selected by purposive sampling. First, the anthropometric variables and body composition were measured, then subjects were randomly divided into two groups (experimental, n=12 and control, n=12). Combined exercise training was done for 8 weeks (5 days/week, 30 to 50 minutes) for experimental group. To analyze the changes in the covariance analysis and dependent t test measured variables at a significance level of p≤05.
Result: After eight-week combined exercise training, fasting blood glucose and plasma visfatin significantly decreased p≤05. But no significant changes were observed in the levels of IL-6 and TNF-α p≥05. Also, the inverse relationship between plasma visfatin with IL-6 and TNF-α was observed (P≤ 0.05).
Conclusion: Eight weeks of combined training despite a positive effect on plasma visfatin, due to no significant changes in plasma IL-6 and TNF-α in patients with type 2 diabetes, it seems this type of exercise in reducing obesity and visceral fat and thereby reducing plasma visfatin is appropriate, but the potential change in IL-6 and TNF-α does.
Seyed Ali Hosseini, Fatemeh Rezvanipour, Nasibeh Kazemi, Omidreza Salehi, Maryam Kasraeian,
Volume 17, Issue 1 (3-2018)
Abstract
Background: Gestational diabetes in on of common complications of pregnancy which has different complications for fetus and mother. Aim of present study was to review the effect of six weeks aqua training in second trimester of pregnancy on visfatin and glucose tolerance of gestational diabetic women.
Methods: In this semi experimental research 24 gestational diabetic mothers who recourse to hafez clinic of shiraz city which were in 23- 24 week of pregnancy select as sample and divided in two groups of 12 persons of aqua training and control. Aqua training group trained aqua trainings 6 weeks, 3 sessions per week and 45 minutes per session. In this period of the time control group has just their daily activities. For measure the research variables fasting blood sample gathered from antecubital vein in pretest and post test.
Results: Six weeks aqua training in second trimester of pregnancy has significant effect on increase of visfatin and decrease of glucose tolerance of gestational diabetic women (p=0.001).
Conclusion: It seems that for improvement of visfatin levels and glucose tolerance of gestational diabetic women can use six weeks aqua training in second trimester of pregnancy.
Fariba Soltanzadeh, Masoumeh Nezhadali, Leila Pishkar,
Volume 23, Issue 3 (9-2023)
Abstract
Background: Type 2 diabetes is a metabolic disease and the most common endocrine disorder. Visfatin is a cytokine with insulin-mimetic effects which is associated with diabetes. The rs61330082 polymorphism is located in the promoter region of visfatin gene and regulates visfatin gene expression. The aim of this study is to investigate the association of rs61330082 polymorphism of the visfatin gene with biochemical and anthropometric variables, visfatin level, diabetes and insulin resistance.
Methods: This case‑control study was performed on 80 patients with type 2 diabetes and 80 controls (persons without diabetes). Biochemical and anthropometric parameters were determined using standard methods. Insulin and visfatin levels were measured by ELISA method. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism method. The data was analyzed with SPSS software.
Results: LDL-C level in healthy people and fasting blood sugar level in patients showed a significant difference in carriers of rs61330082 polymorphism genotypes. No associations was found between visfatin level and single nucleotide polymorphism rs61330082 in the current study. Regression analysis showed that genotypes of rs61330082 polymorphism are not significantly associated with type 2 diabetes and insulin resistance.
Conclusion: The rs61330082 polymorphism is associated with LDL-C in healthy subjects and FBS in patients with T2D. Visfatin rs61330082 polymorphism is not associated with visfatin level and type 2 diabetes and insulin resistance.
Paria Maghouli, Roghayyeh Afroundeh, Mohammad Ebrahim Bahram, Amaneh Pourrahim Ghoroughchi,
Volume 24, Issue 2 (6-2024)
Abstract
Background: The aim of this study was to investigate the effect of eight weeks of circuit resistance training and saffron supplement on visfatin serum levels and insulin resistance in overweight men.
Methods: In this semi-experimental study, 40 obese and overweight students were randomly divided into 4 groups: exercise, exercise+supplement, supplement and control (10 people in each group). The exercise groups performed circular resistance exercises for eight weeks and three sessions each week for 90 minutes in the evening. The supplement and exercise+supplement groups used saffron tablets with a dose of 30 mg per day as a supplement. Blood samples were collected in two phases of the pre-test and 48 hours after the last training session. The data were analyzed using covariance and paired t test at a significant level of P≤0.05.
Results: Correlated t results showed a significant decrease in visfatin and insulin resistance in the post-test of the training, training+supplement and supplement groups compared to the pre-test (P<0.05). The results of the analysis of covariance showed that visfatin increased and the insulin resistance index decreased significantly in the exercise, exercise+supplement and supplement groups compared to the control group (P<0.05).
Conclusion: It seems that eight weeks of circuit resistance training and the addition of saffron help on visfatin serum levels and insulin resistance can lead to the reduction of these two variables in overweight men. The saffron plant can play a protective role due to the presence of flavonoids and by stimulating the secretion of Visfatin.
