Majid Karandish, Fateme Mofidi, Mohamad Taha Jalali, Anahita Mansouri,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Alternate Day Fasting (ADF) is one of dietary regimens in which food is available only
every other day. Available limited evidence shows that this regimen may result in beneficial effects
similar to classic caloric restriction, including weight loss and other associated useful effects of weight
loss.
Methods: Twelve week-old Wistar rats were obtained from animal house of Jundi Shapur University
and fed a standard diet. Food was provided ad-libittum (AL) until 13 week of age. At that time rats
were assigned to one of two groups: AL fed ad libitum or ADF, provided access to food every other
day. Body weight was measured each week on the same day and time. Food intake was measured
daily. Fasting blood glucose levels were measured before and after the intervention. Statistical tests
performed as two-tailed and P value of less than 0.05 was considered as statistically significance level.
Results: At the end of the intervention period body weight and food intakes of the (ADF) group were
significantly lower than AL group (p<0.05) but there were not significant changes in fasting blood
glucose levels.
Conclusion: According to findings of this experimental study, ADF regimen could be used as an
individualized eating strategy for weight loss but it could not have beneficial effects on fasting blood
glucose levels.
Yazdan Ahmadi, Parisa Shabanzadeh,
Volume 19, Issue 6 (8-2020)
Abstract
Background: Over the past half-century, the prevalence of obesity and related metabolic disorders such as fat disorders, cardiovascular disease, myocardial infarction and stroke have increased dramatically. Various types of organisms, including bacteria, fungi, protozoan, and viruses, have evolved to live in the human gut, called microbiota. Scientists have found that thin people have a balanced microbiota in their gut that causes them to lose weight, so they use a method called fecal grafting and fecal capsules to treat obesity. The aim of this study is to introduce fecal graft and its capsule in the treatment of drug-resistant obesity.
Methods: This article is a systematic review of the study which English and Persian articles are obtained from regular search of Internet resources using logical AND, OR function between keywords in Pub Med, Google scholar databases using English keywords, FMT, obesity, poop capsule, weight loss has been done from 2010-2020. The total search for fecal transplant related resources was 474 articles. Then, by applying the time filter, this number was reduced to 237 articles. In the final stage, by eliminating duplicate articles and examining the relationship of articles with the subject under study, 23 articles were selected as relevant and final sources.
Results: In the treatment of obesity with FMT, the donor's stool is transferred to the recipient after screening and necessary tests using various methods such as enema or colonoscopy, and then the recipient gradually loses weight by receiving a balanced microbiota of the donor. Instead of a stool transplant, which is a relatively invasive procedure, stool capsules consisting of the donor's dried stool can be used.
Conclusions: Stool transplantation and fecal capsule are an effective method in weight loss of obese people (BMI> 30) with due consideration. Due to the novelty of the treatment method, further studies in this field, especially clinical studies of this method in the treatment of obese people in the country are also recommended.
