Showing 29 results for Aerobic Exercise
Fatemeh Mokhtari, Fahime Esfarjani, Mehdi Kargar Fard,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Physical activity with diet and medication–considered fundamental in the treatment of diabetes. The aim of this study was to determine the effect of combined 12-week aerobic exercise and barley β glucan (BBG) on blood glucose and lipid profile in patients with type 2 diabetes.
Methods: Twenty- four female volunteers (49±5 years) were selected, and after completion of questionnaires, were randomly divided into three groups a) aerobic training with diet group (n=8), b) diet group (n=8) and c) control group (n=8). The diet group used one barley bread per day with 4 gram beta glucan during 12 week. The combined group participated in progressive walking training program with intensity of 60-70% of maximal heart rate 2 to 3 times a week, 20 to 60 minutes in each session in addition to diet program. The variables measured included blood sugar, triglyceride, cholesterol, LDL, HDL. For data analysis ANOVA used to compare mean differences between groups.
Results: Results indicated significant difference in blood sugar between control and experimental groups while non significant changes was observed in lipid profile.
Conclusion: Aerobic exercise and BBG can decrease blood glucose in patients with diabetes Therefore, it should be considered seriously as part of the treatment of these patients.
Hamed Rezaei Nasab, Roohollah Ranjbar, Abdol Hamid Habibi, Saeed Shakerian,
Volume 14, Issue 2 (1-2015)
Abstract
Background: The purpose of this study was to compare three intensities of acute aerobic exercise on plasma visfatin concentration in type 2 diabetic males. Methods: Ten men with type 2 diabetes (mean ± SD age 52.6 ± 3.6 years, height 171.3 ± 6.7 cm, Weight 87.58 ± 4.7 kg) participated in the study. In the first session, anthropometric measurements, body composition, and peak oxygen uptake (VO2peak) was measured in all subjects. In the next sessions, subjects completed three acute aerobic exercises on separate days in a crossover design. The three exercise trials performed at intensity of 40%, 60%, and 80% VO2peak after fasting for at least 10 hours. Energy expenditure was 300 kcal for each exercise trial. Blood samples before exercise, immediately after and 24 hours after exercise were collected for measuring visfatin, glucose and insulin. Results: The results showed no significance interaction (p>0.05) between exercise and sampling time. This analysis also revealed significance in the main effects (p>0.05) of the two factors (exercise and sampling time). Pearson correlation showed that there was significant relationship between visfatin and insulin (p<0.05). Conclusion: According to the present results, we can conclude that acute aerobic exercise at different intensities with 300 kcal energy expenditure will not change visfatin levels in type 2 diabetes.
Saber Saedmocheshi, Mohammad Reza Almori, Lotfolah Saedmocheshi ,
Volume 14, Issue 4 (5-2015)
Abstract
Background: Hyperlipidemia is a major cause of cardiovascular diseases (CVD) and the most common problems in the community. The present study examined the effect of grape seed supplementation along with aerobic activity on lipid profile in elderly women Methods: In this experimental study, 40 obese women (BMI&ge30 kg/m2) over 60 years were selected and randomly divided into two groups (supplement + Exercise and control group). The exercise program included aerobic exercise with 50% of maximum heart rate for three times a week for 8 weeks plus Grape seed extract supplement 200 mg daily for 8 weeks. Blood sampling after fasting period for 12 hours in pretest and 48 hours after the last training session was taken. To compare data between groups t-test was used. Results: The results showed significant differences in the levels of cholesterol, triglycerides and LDL-C and pre-test and post-test group supplemented along with sports activities. Conclusion: Long-term aerobic exercise combined with grape extract consumption may reduce the lipid profile parameters.
Alireza Safarzade, Fakhri Baradaran-Jam, Elahe Talebi-Garakani, Rozita Fathi,
Volume 14, Issue 5 (7-2015)
Abstract
Background: kallikrein 7 (KLK7), a serine protease with a chymotrypsin-like specificity, is able to cleave human insulin in the A- and B-chain. The aim of this study was to investigate the effects of aerobic exercise training on plasma KLK7 concentration and insulin resistance index (HOMA-IR) in normal and overweight sedentary women.
Methods: Twenty-eight sedentary women, aged 24-60 years, voluntary participated in this study and according to body mass index status divided into normal (n=15) and overweight (n=13) groups. All subjects completed an 8-week progressive aerobic exercise training program (running with 40- 80% Heart rate reserve). Metabolic and Anthropometric (body weight, BMI, body fat percentage) parameters in addition to plasma KLK7 concentrations were measured at baseline and end of training program.
Results: Body fat percentage significantly decreased (P<0.05) and maximum oxygen consumption increased (P<0.05) by this training program in both training groups. At baseline, plasma KLK7 concentration in overweight women was significantly higher compared with normal weight group (P<0.05). Plasma KLK7 concentrations significantly increased after 8-week aerobic exercise training only in normal weight group (P<0.05). Changes in plasma KLK7 concentrations were not correlated with changes in insulin concentration and insulin resistance index (P<0.05).
Conclusion: Aerobic exercise training could be an effective factor to increase plasma KLK7 concentration in sedentary women. These data do not support a role of plasma KLK7 in insulin resistance alterations.
Parvin Farzanegi, Farzaneh Shokrian,
Volume 15, Issue 1 (1-2016)
Abstract
Background: Type 2 diabetes is a chronic disease that leads to many complications such as atherosclerosis. Matrix Metalloproteinase (MMPs) family plays a key role in atherosclerosis and remodeling of the vessel wall. The aim of this study was determination the Effect of eight weeks aerobic exercise with Portulaca oleracea seeds consumption on MMP-1, MMP-3 and MIP-1α in women with type 2 diabetes.
Methods: In one Quasi-experimental study 28 women with type II diabetes (44 to 65 years old) selected and divided into 4 groups (Exercise, Supplement, Exercise-Supplement and Control groups) randomly. Exercise program included 8 weeks (3 sessions per week) with 50 to 70% of maximum heart rate. Supplemented groups received 7.5 g Portulaca oleracea seeds every day. Blood samples were collected before and after the 8 weeks with 12 hours fasting conditions. P < 0.05 considered statistically significant.
Results: Eight weeks of the aerobic training or portulacalo consumption cause a significant decrease in MMP-1، MMP-3 و MIP-1α levels, in comparison to pretest. However, the effectiveness of combination training and supplement is better in the above indicators. MMP-1 levels showed a significant difference between supplement, training, training- supplement group with control group (P = 0.001) and between supplement exercise group with training- supplement (Respectively P = 0.018, P =0.039). MMP-3 levels showed a significant difference between supplement with training- supplement (P = 0.007) and control group (P = 0.011), exercise group with training- supplement (P = 0.026) and control group (P = 0.04). MIP-1α levels showed a significant difference between training- supplement and control group (P = 0.001).
Conclusion: The results showed both intervention exercise and purslane may be support from due to the effects of antioxidant and anti-inflammatory from oxidative stress induced diabetes and combination therapy was associated with synergistic effects.
Mahin Nasrabadi, Mehdi Mogharnasi,
Volume 15, Issue 3 (2-2016)
Abstract
Background: Omentin-1 is known as adipokines that are secreted by visceral fat tissue. Omentin-1 levels are inversely associated with obesity. The aim of this research was investigation of the effect of Rhythmic aerobic exercise on serum concentration of Omentin-1 and same Anthropometric markers in obese women.
Methods: Thirty two obese women voluntarily selected with mean age 37± 8 years old and body mass index of 32.34±3.54 kg/m2 and randomly were divided into two groups of experimental (n=17) and control group (n=15). Subjects in the experimental group performed the exercise training with intensity 80-70% of maximum heart rate for 45-60 minutes per session, three times a week for 10 weeks. The control group did not participate in any exercise program. Omentin-1 serum levels, weight, body mass index and waist-to-hip ratio was calculated before and after exercise. Collected data were analyzed by using of Shapiro-Wilk, Leven, dependent t test and analysis of covariance (ANCOVA) with software SPSS version 21 in significant level of α<0.05 or α<0.001.
Results: 8 week aerobic exercise in the experimental group was associated with a significant increase in the omentin-1 levels (P=0.0001) and significant reduction of weights and body mass index (p= 0.0001) (P<0.05). Whereas there was no significant change in WHR levels (P>0.05). Reviews for between group indicated a significant increase in the amount of omentin-1 (P=0.009) and a significant reduction in weight values (P=0.0001) and BMI (P=0.001) in the experimental group compared with the control group (P<0.01).
Conclusion: It seems that rhythmic aerobic exercise is an important role in improving cardiovascular health and obesity-related disorders in obese women by increasing omentin-1 and reducing obesity-related factors.
Mir Hojat Mousavinezhad, Hassan Matin Homaee, Mohamad Ali Azarbaijan, Maghsood Piri,
Volume 15, Issue 6 (7-2016)
Abstract
Background: Exercise training is identified as a beneficial component of diabetes treatment plan. Angiogenesis process in diabetics can be affected by exercise activity. The purpose of this study is to determine the effect of aerobic exercise on the expression of mir-126 and capillary density in the cardiac tissue of diabetic rats.
Methods: Twenty diabetic male Wistar rats (mean weight, 191.9±10.85) were divided into two groups of control (n=10) and training (n=10) and the groups were matched based on weight. 48 hours after the last training session, cardiac tissue samples were taken after an overnight fast. Mir-126 expression was used through Real Time PCR. Also, immunohistochemistry (alkaline phosphatase activity) was used to measure the cardiac muscle capillary density.
Results: Independent t-test showed that the 8-week aerobic training significantly increased the expression of mir-126(p=0.001) and capillary density (p=0.018) of cardiac tissue in the exercise group compared to the control group.
Conclusion: The results of this study indicate that the development of angiogenesis by aerobic exercise in diabetic conditions; can be expressed as a non-drug treatments for aerobic exercise and can be used to improve heart perfusion.
Fahimeh Kazemi, Saleh Zahedi Asl,
Volume 16, Issue 2 (1-2017)
Abstract
Background: Recently the role of apelin in inflammation has been known. However, the effect of exercise training-induced cytokine apelin in diabetes status hasn’t been investigated. The purpose of this study was to determine the atni-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats.
Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-α and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation was used for analyzing data. P<0.05 was considered to be statistically significant.
Results: Results showed a significant decrease in plasma concentrations of glucose, insulin and TNF-α and HOMA-IR in trained diabetic vs control diabetic group, a significant increase in plasma concentration of apelin in trained diabetic group vs non-diabetic and control diabetic group and a significant negative correlation between plasma concentrations of apelin and TNF-α in trained diabetic group.
Conclusion: It appears that 8-week aerobic training by improvement of insulin sensitivity and decrease of inflammation can increase plasma concentration of apelin in diabetic male rats.
Rahman Soori, Nikoo Khosravi, Shaghayegh Jafarpour, Azam Ramezankhani,
Volume 16, Issue 2 (1-2017)
Abstract
Background: Inflammation plays an essential role in the insulin resistance process, and chemokines, such as chemerin, seem to play a pivotal role in the pathogenesis of insulin resistance. The aim of this study was to compare the effects of aerobic exercise and caloric restriction on chemerin levels and insulin resistance index in women with type 2 diabetes.
Methods: In a quasi-experimental study, 30 type 2 diabetes women were recruited (Mean age: 49.3±5.4 yr; weight: 78.8±7.3kg). Subjects randomly were divided into three groups: caloric restriction (experimental group 1 or CR), aerobic exercise with caloric restriction (experimental group 2 or EX+CR) and control group. In CR group, subjects follow a diet with 25% caloric restriction for 12 weeks. Subjects in CR+EX group used a training program including aerobic exercise and running on treadmill and diet with 50% caloric restriction of CR group (12.5% caloric restriction+12.5% increase in energy expenditure). Before and after 12 weeks, blood sampling for measurement of chemerin, IL-6, glucose and insulin was carried out. Data were analyzed by paired sample t-test and one way ANOVA at significant level of p<0.05.
Results: Results showed that body mass index (BMI), waist to hip ratio (WHR), insulin resistance index (HOMA-IR) and interleukin6 decreased significantly in experimental groups. chemerin levels were increased significantly in CR (P=0.001) and EX+CR groups (P=0.001). Significant correlation were seen between changes of chemerin with changes of BMI, WHR, HOMA-IR and interleukin6 (P<0.05).
Conclusion: According to the relationship between chemerin and insulin resistance and also, its effectiveness of aerobic exercise and caloric restriction, decreased levels of chemerin may play a special role in reduction of insulin resistance.
Laleh Ranjbar, Farzaneh Taghian, Mehdi Hedayati,
Volume 17, Issue 4 (5-2018)
Abstract
Background: Apelin is an Adipokine which is recently discovered and widely secreted from white adipose tissue and in fat and overweight person, apelin values and gene expression increase .In this study, the effect of one period aerobic exercise and vitamin D consumption on weight, plasma apelin values and insulin resistance in overweight women was researched.
Method: In order to doing this reasearch 40 women whom have over weight with , average old , weight , height, BMI and WHR respectively : (30.37 ± 6.91) years old , (74.89 ± 12.97) kg , (157 ± 7.02) m , (30.08 ± 3.95) kg/m2 , (0.81 ± 0.07). After passing the medical sepration dived to 4 experimental group: 1st experiment group (aerobic exercise) n=10, 2nd experimental group (aerobic exercise and vitamin D) n=10, 3rd experimental group (vitamin D) n=10 and control group n=10. At first body composition was measured th included: BMI, WHR, weight, waist and hip size. After that the blood sample was taken from triables. (Fasting) and amount of the apelin, glucose, insulin, vitamin D, triglycerides, cholesterol, LDL and HDL were measured. Then experimental group 1 and 2 were encounterd and emotionalized by an aerobic exercise (treadmill) after 10 weeks all of the measure mented conversionxls were measure again befor the test. For comparisoning of the groupa that befor and after the test was used from –t test and if was used from the variance test for comparisoning two group.
Results: results showed that after 10 week of aerobic exercise an vitamin D using : BMI, WHR, apelin, cholesterol, LDL, glucose, insulin and insulin resistance were reduced, a triglyceride also decrease and HDL had a significant increasing.
Conclusion: Result confirmed the positive effect of the aerobic exercise on body compositions apelin and plasmas Lipoprotein and also showed that using vitamin D using in obese people and people who have overweight can be beneficials.
Sepideh Soltani , Farzaneh Taghian,
Volume 18, Issue 3 (3-2019)
Abstract
Background: The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and supplementation of gensing on homocysteine levels, tiroid hormon and insulin resistant in obese women with hypothyroidism.
Methods: This study is quasi-experimental study. For this purpose, 40 obese women with hypothyroidism with an average age of 34.62 ± 3.55 years, weight 80.47 ± 3.85 kg and BMI of 32.2 ± 2.27 kg / m2, were randomly divided into four groups including aerobic training (10), ginsing (10), aerobic exercise and ginsing (10) and placebo (10) were divided.Aerobic exercise included 8 weeks of aerobic training, 3 sessions per week, 45 to 70 minutes, and 55 to 75% of maximum heart rate. Patients in the ginseng group and aerobic exercise with ginsing consumed each day a Jinsen's capsule containing 250 mg of granule Risomy ginseng powder was taken orally after 8 weeks for 8 weeks, while subjects in the placebo group received flour powdered capsules.Blood samples from the anterior vein were used to measure homocysteine, TSH, T3, T4, glucose and insulin before and after 8 weeks in four groups. For data analysis, dependent t-test and variance analysis were used (P≤0/05).
Results: The results showed that the plasma homocysteine, TSH, glucose concentrate, insulin resistance and insulin resistance were significantly decreased in all three experimental groups while T3 and T4 increased (P <0.05). These indices in the control group were not changed (P <0.05).
Conclusion: Therefore, aerobic exercise, along with supplementation with ginsing, can have an important role in preventing an increase in cardiovascular risk factors and hypothyroidism in obese women with hypothyroidism.
Reza Omidi Ghanbari, Rahman Soori, Ahmad Hemmatfar,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Adropin is a peptide hormone playing a role in energy homeostasis and prevention of obesity. The aim of this study was to investigate the effects of aerobic exercise with low intensity on serum adropin levels and insulin resistance index (HOMA-IR) in obese sedentary adolescent boys.
Methods: This study was carried out in a quasi-experimental design. 26 obese adolescent boys were recruited (Mean ± SD: 13.4±0.81 yr; weight: 85.44±8.51kg) and were randomly assigned into two groups: aerobic exercise and control group. The training group performed running with intensity of 50-65% of maximal heart rate, three times a week for 10 weeks. Before and after intervention, blood sampling for measurement of serum adropin, fasting insulin and glucose was carried out. Data were analyzed by paired t-test and independent t-test at significant levels of P≤0.05.
Results: Weight (P=0.001) and body fat percent (P=0.017) showed significant reduction in aerobic group in posttest compared to pretest and control group. Serum adropin levels were increased significantly in aerobic exercise group compared to pretest and control group (P=0.0001). Significant correlation was seen between changes of adropin with changes of weight, body fat percent and HOMA-IR (P≤0.05).
Conclusion: According to the relationship between adropin with body composition and insulin resistance and also, its influence from aerobic exercise, adropin may play a special role in weight and obesity management.
Hadi Afshar Bakeshlou, Ahmad Abdi, Mohammad Ali Azarbayjani, Alireza Barari,
Volume 19, Issue 2 (1-2020)
Abstract
Background: Diabetes is a chronic and progressive metabolic disorder that leads to more severe cardiac complications. The aim of the present study was to investigate the effects of Berberine chloride at a dose of 50 mg / kg on the heart tissue of streptozotocin-induced diabetic rats with aerobic training.
Methods: 56 male Wistar rats were randomly divided into seven groups (n = 8): control (C), sham (S), Aerobic training control (TC), diabetes mellitus (DM), diabetes-berberine (BDM), diabetes mellitus. Aerobic training (TDM), and aerobic training-berberine (TBDM) were divided. Diabetes was induced by injection of streptozotocin in male rats. The training groups performed aerobic exercise program (10-18 m / min, 10-40 min five days a week) for six weeks on the treadmill for histological evaluation using hematoxylin and eosin (H&E), Masson trichrome and staining Immunohistochemicals were used to measure diameter change, cardiomyocyte rupture, change in nuclei, and collagen deposition in cardiac muscle fibers using one-way ANOVA and Tukey post hoc tests with SPSS 21 software.
Results: The results showed that DM group did not induce cardiomyocyte fibers rupture and collagen deposition and reduction of filament diameter in group C, S and TC and its damage in heart tissue was less in TBDM group than in BDM and TDM groups.
Conclusion: The results showed that berberine supplementation reduced these effects and synergized with aerobic training and reduced the cardiac cardiomyocyte muscle fibers diameter and decreased collagen deposition and better order of nuclei.
Mahdi Angouti, Hamid Rajabi, Reza Gharakhanlou, Mohammad Reza Dehkhoda,
Volume 20, Issue 2 (1-2021)
Abstract
Background: Diabetes causes nerve tissue damage and ultimately death of nerve cells, especially in important areas such as the hippocampus. It seems that exercise training and anti-inflammatory supplements can moderate this condition. Therefore, the aim of this study was to determine the effect of aerobic training exercise and L-carnitine consumption on the levels of hippocampus CNTF and CNTFR proteins in diabetic rat.
Methods: 45 Wistar rats between 250 to 300 gr were randomly divided into six groups, including healthy control groups, sham, diabetic control, diabetes
+ aerobic exercise, diabetes + L-carnitine supplementation and diabetes + aerobic exercise + L-carnitine supplementation. L-carnitine supplements were divided. Diabetic groups underwent subcutaneous injection of 55 mg / kg STZ. supplementary groups received 100 mg of L-carnitine per day orally. The aerobic exercise program was performed for 6 weeks and 5 days a week. The research variables were measured 24 hours after the last training session by the ELISA technics in the hippocampal tissue. The statistical method of one-way analysis of variance and Toki post –hoc test were used to analyze the data.
Results: The present study showed an significant increase in CNTF and CNTFR protein levels of hippocampal tissue after aerobic exercise and L-carnitine consumption (P = 0.001), which greater effect found in combination manner.
Conclusion: Due to the effect of aerobic exercise and L-carnitine supplementation alone and in interaction with each other on hippocampal tissue, the use of this method can be considered as maintaining neural tissue in diabetes.
Maghsoud Nabilpour, Abbas Sadeghi,
Volume 21, Issue 3 (9-2021)
Abstract
Background: One consequence of diabetes mellitus is increased inflammation, which is exacerbated by training. The objective of this study was to evaluate the effect of eight weeks of aerobic moderate-intensity continuous training on Interleukin-1 beta, Interleukin-13 responses in male Wistar diabetic rats
.
Methods: 36 diabetic rats were randomly assigned into 3 equal groups (control (C), diabetic (D), and diabetes + training (D + T)), and subjected to eight weeks of aerobic moderate- intensity continuous training intensity at the first: the10 min on 10m/min and at the final: 55min on 26m/min speed. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the pro-inflammatory and anti-inflammatory indicators. ANOVA and Scheffe post hoc tests were used for data analysis
.
Results: Induction of
diabetes caused a significant increase in IL-1β and IL-13 (P<0.001) and continuous exercise intervention also significantly reduced IL-1β levels in diabetic rats (P = 0.02). However, there was no significant change in IL-13 in D + T group compared to D group (P = 0.985).
Conclusion: According to the results of this study, the effect of aerobic exercise is probably a positive effect on reducing the pro-inflammatory index of IL-1β and no effect on the anti-inflammatory index of IL-13 in diabetic rats. However, definitive confirmation of these results requires further research in this area.
Maryam Delfan, Tina Bouriaei,
Volume 21, Issue 4 (10-2021)
Abstract
Background: One of the most common problems in diabetic patients is muscle atrophy. Therefore, the present study aimed to investigate the synergistic effect of endurance training with probiotic supplementation on Atrogin-1 and MuRF-1 genes gene expression in the soleus muscle of diabetic rats.
Methods: In this study, 32 male Wistar rats were randomly divided into one normal control (NC) and four diabetic groups: diabetic control (DC), diabetic supplement (SDC), diabetic training (TD), and diabetic supplement training (STD). The training protocol was performed with 60 to 65% of maximum speed reached five days a week for four weeks. At the same time, rats took two grams of probiotic dissolved in 30 ml of water daily. Expression of Atrogin-1 and MuRF-1 genes was measured by the qReal-TimePCR method. Data were analyzed by two-way analysis of variance at the significant level of P≤0.05.
Results: Atrogin-1 gene expression was significantly reduced in TD (P=0.001) and STD (P=0.000) groups compared to DC group. There was a significant difference between TD and STD groups in the expression of the Atrogin-1 gene (P=0.028). MuRF-1 gene expression was significantly reduced in TD (P=0.04) and STD (P=0.01) groups compared to DC. But there was no significant difference between TD and STD groups in MuRF-1 gene expression (P=0.36).
Conclusion: It seems that performing the aerobic exercise with probiotic supplementation is more effective in reducing the expression of the Atrogin-1 gene than any of these interventions alone. However, aerobic exercise with probiotic supplementation does not have a synergistic effect on reducing MuRF-1 gene expression in the soleus muscle of diabetic rats compared to aerobic exercise alone.
Akram Batvandi, Ahmad Kaki,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Dysfunction of Schwann cells by diabetes has far-reaching consequences for the structure and function of peripheral nerves. The aim of the present study was to evaluate the effect of aerobic exercise on the Nrg1 / ErbB2 signaling pathway in male rats with diabetic neuropathic pain.
Methods: Twenty-four 8-week-old male Wistar rats (weight range 204 ± 11.3 g) were randomly divided into three groups (n = 8) including: Diabetic neuropathy (50 mg / kg streptozotocin injection), Diabetic neuropathy Exercise (30 minutes exercise aerobics intensity 15 m/min, 5 days per week for 6 weeks), and healthy controls. After confirmation of diabetic neuropathic pain by behavioral tests, aerobic exercise protocol was performed. The expression of Nrg1 / ErbB2 genes was measured by real-time technique. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis.
Results: Aerobic exercise reduced the nervous system's sensitivity to thermal hyperalgesia and mechanical allodynia. Induction of diabetes significantly reduced Nrg1 and ErbB2 gene expression. There was also a significant increase in the expression of the above genes in the exercise group compared to the diabetic neuropathy group (P<0.05).
Conclusion: It seems that aerobic exercise is effective in increasing the nerve repair process by activating growth signaling pathways in Schwann cells. It is recommended that aerobic exercise be used for diabetics to reduce neuropathic pain.
Mahnaz Omidi, Parya Vismoradi,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Adipulin is a hormone secretd by fat cells that acts as a metabolic regulator with anti-inflammatory properties and is reduced through obesity, diabetes and inflammation. Therefore, the aim of this study was to compare the effect of high and moderate intensity aerobic exercise on serum adipolin levels and some indicators of metabolic syndrome in obese women.
Methods: In this quasi-experimental study, 36 people were randomly divided into three groups of 12 people (2 experimental groups and one control group). Aerobic exercise group with an intensity of 85-95% of maximum heart rate performed intermittent walking and running on the treadmill for 33 minutes per session and exercise group with an intensity of 50-70% of maximum heart rate walked continuously for 41 minutes. (Training duration for 2 groups was 8 weeks and 3 sessions per week, The control group was not active during this period). One-way analysis of variance statistical and Bonferroni post hoc tests were used at the significant level (P> 0.05).
Results: High intensity aerobic exercise significantly increased serum adipolin levels (P= 0.001) and decreased total cholesterol (P= 0.020), triglyceride (P= 0.021) and insulin resistance (P= 0.001). The results also showed no significant differences in the levels of high-density lipoprotein (P= 0.615), low-density lipoprotein (P= 0.604), and blood pressure (P= 0.269) in the three groups. Medium-intensity aerobic exercise had no effect on serum adipoline levels (P= 0.192), only glucose, (P= 0.025), triglycerides (P= 0.010), systolic blood pressure (P= 0.028) and insulin (P= 0.043) decreased and the levels of cholesterol, low-density lipoprotein and high-density lipoprotein did not change significantly.
Conclusion: In the end, it can be said that it seems that individuals can use high-intensity aerobic exercise to increase the amount of adipolin as an indicator of improving insulin sensitivity and also improving the indicators of metabolic syndrome.
Eftekhar Mohammadi, Mohammad Fathi, Farzaneh Chehelcheragi, Afshin Nazari,
Volume 22, Issue 1 (4-2022)
Abstract
Background: The aim of this study was to evaluate the effect of eight weeks of endurance training and Empagliflozin consumption on inflammatory markers and their relationship with heart structure and function of diabetic male Rats.
Methods: 40 male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + empagliflozin, diabetic + endurance training and diabetic + endurance training + empagliflozin. The groups were anesthetized and their cardiac function and TNF-α and TGF-β indices were evaluated by one-way ANOVA and Pearson correlation tests after performing the training protocol and receiving medication.
Results: There were significant differences in left ventricular end systolic thickness (P = 0.011), left ventricular end systolic volume (P = 0.008), TNF-α (P = 0.014) and TGF-β (P = 0.001) was observed between the research groups. Also, there was a significant negative relationship between TGF-β with body weight, heart fiber shortening percentage and injection fraction and a significant positive relationship with glucose levels, left ventricular end systolic thickness and left ventricular end systolic volume. In addition, a significant negative correlation was observed between TGF-β and the injection fraction (P≤0.05).
Conclusion: Aerobic exercise seems to improve the inflammatory status, structure and function of diabetic heart tissue beyond the dual effect of Empagliflozin.
Maryam Janbozorgi, Abass Ali Gaini, Siroos Choobineh, Mohamad Reza Tabandeh,
Volume 22, Issue 1 (4-2022)
Abstract
Background: Chronic hyperglycemia is associated with an increase in cellular damage due to oxidative stress and increases insulin resistance and also increases in p53 and p16 beta cells, leading to the induction of senescence in pancreatic insulin-secreting cells. The aim of this study was the effect of eight weeks of aerobic exercise on the expression of senescence proteins P53 and P16 in the pancreatic tissue of diabetic mice.
Methods: In this study, 15 NMRI mice (26.3 ±3.22 g) were divided into three groups randomly: healthy control, diabetic control and diabetic exercise. They were diabetic by HFD for 5 weeks and intraperitoneal injection of STZ. The aerobic training protocol (50-60% Vmax) was 5 days a week for 8 weeks. After anesthesia, blood and pancreatic tissue were removed. Insulin resistance, P53 and P16 protein concentrations in pancreatic beta cells were measured. Data were analyzed by ANOVA with a significance level of p <0.05.
Results: According to the results of eight weeks of aerobic exercise by mice diabetic type 2, a significant decrease in insulin resistance (p = 0.005), protein concentrations of P53 (p = 0.002) and P16 (p = 0.010) in pancreatic tissue was observed.
Conclusion: Aerobic exercise may improve insulin sensitivity and delay cellular senescence due to diabetes by reducing cell senescence factors such as P53 and P16 in beta cells. Therefore, this type of exercise can be considered as a therapeutic approach to improve the condition of these patients.
