Showing 1 results for Endurance Training. Rbp4
Rohollah Nikooie, Malihe Aveseh, Kobra Omidfar,
Volume 13, Issue 2 (1-2014)
Abstract
Background: the aim of the present study was to investigate the effects of diabetes and seven weeks
of endurance training on RBP4 expression in Soleus, extensor digiturom longuse (EDL), liver, visceral
and subcutaneous fat in type 2 diabetic rats.
Methods: Fifty male wistar rats (93.7 ± 8.9 g) were randomly divided into four groups including:
control (C) [n=10], trained (T) [n=10], diabetic control (DC) [n=15] and diabetic trained (TD) [n=15].
The combination of Intraperitoneally injection of streptozotocin (STZ) and high fat diet feeding were
used for diabetes induction. After seven weeks of endurance training, serum RBP4 and its expression
in above tissues were measured by ELISA and western blotting techniques, respectively.
Results: diabetes induction increased the RBP4 expression of the liver (3.57-fold, p < 0.01), visceral
fat (2.02-fold, p < 0.01), and subcutaneous fat (1.84-fold, p < 0.01) and EDL (2.29-fold, p < 0.01) in
DC in comparison to C group. Serum RBP4 concentration was significantly higher in DC (2.9-fold, p
< 0.01) and TD (1.84-fold, p < 0.01) in comparison to C group. Endurance training significantly
decreased serum RBP4 (p < 0.01) and its expression in visceral fat (p < 0.01) in DT in comparison to
DC.
Conclusion: type 2 diabetes extensively decreases the skeletal muscle RBP4 expression in isoform –
specific manner, liver, subcutaneous and visceral fat. In addition, endurance training decreases serum
RBP4 concentration and its expression in visceral fat.
