Showing 4 results for Hs-Crp
Amir Bahrami, Nosratollah Zarghami, Liela Khajehali,
Volume 6, Issue 3 (5-2007)
Abstract
Background: Type 2 diabetes mellitus is a common metabolic disorder witht increasing prevalence is increasing worldwide. C-Reactive Protein (CRP) is a marker of systemic inflammation and an independent risk factor for cardiovascular disease (CVD). The aim of this study was to elucidate the correlation between glycemic control and systemic inflammation by measuring serum CRP levels.
Methods: In this cross sectional study 136 patients with type 2 diabetes mellitus (69 females, 67 males) were recruited. In addition to measurement of CRP levels by highly sensitive methods and measurement of hemoglobin A1C effects of influencing factors on the CRP level was considered. Fasting plasma glucose was determined via the glucose oxidase method, HbA1C via HPLC, serum lipid profile enzymatically and hs-CRP with sandwich immunoassay method.
Results: The mean concentrations of CRP levels in these patients (5.2 ± 4.8 mg/L) were higher than normal range and in women greater than men (6.4 ± 5.5 vs. 3.9 ± 3.6 mg/L). Before adjusting for influencing factors the association between hs-CRP levels and hemoglobin A1C was negative but not statistically significant (r= -0.15, P=0.07). After adjusting, the association was negative and significant. (r= -0.22, P= 0.02). In this study the relation between hs-CRP and lipid profile was also determined. There was no significant relationship between the levels of hs-CRP and total cholesterol, LDL-C and HDL-C. A positive correlation between hs-CRP with serum triglyceride and triglyceride / HDL ratio was observed. However, the correlation was not significant.
Conclusion: These results demonstrate that hs-CRP levels is influenced with multiple factors, and increased hs-CRP levels in patients with type 2 diabetes mellitus can not be explained with hyperglycemia alone.
Bita Faam, Maryam Zarkesh, Maryam Sadat Daneshpour, Fereidoun Azizi, Mehdi Hedayati,
Volume 13, Issue 2 (1-2014)
Abstract
Background: It is now evident that adipose tissue functions as an endocrine organ by releasing
adipokines, and the levels of a number of inflammatory markers elevated in overweight and obese
individuals. The objective of this study was to examine the association between inflammatory markers
(IMs) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Homocystein (Hcy) and obesity
variables in Tehran Lipid and Glucose Study (TLGS) adults.
Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years,
were randomly recruited from among TLGS population. Individuals were categorized based on the
waist circumference. The serum levels of IMs were determined using the Enzyme Linked
Immunosorbent Assay (ELISA) method.
Results: The mean age of participants was 46.1±16.1years and Abdominal obesity were present in
199(56.5%) individuals. The levels of hs-CRP and IL-6 were higher in abdominally obese group
(1507±3.3 vs. 577.8±4.3 ng/mL p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/mL p< 0.001), and in the same
group, the best predictors (based on the adjusted R2) for hs-CRP, IL-6 and Hcy were waist (WC),
waist to height ratio (WHtR) and wrist, respectively. Hip and WHtR were the best predictors for Hcy
and hs-CRP in normal group there was no variable significantly correlated with IL-6, therefore it was
not possible to consider an independent predictor for IL-6.
Conclusion: According to this study, obesity is associated with IM levels, and in abdominally obese
group, the best predictor for Hcy, hs-CRP and IL-6 were Wrist, waist and WHtR respectively.
Leila Zamanpour, Ebrahim Banitalebi, Seyed Ehsan Amirhosseini,
Volume 15, Issue 5 (7-2016)
Abstract
Background: The purpose of this study is to the comparison of the effect of 12 weeks of sprint training and concurrent aerobic and strength training on high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and insulin resistance in women with diabetes mellitus (T2DM)
Methods: 52 overweight female type 2 diabetic patients (age; 45-60 years old and fasting blood glucose ≥ 126 mg/dl (7.0 mmol/l)) were assessed for eligibility. Participants were assigned to intense interval training group (N=17), concurrent resistance- endurance training group (N=17) and control group (N=18). The combined strength-endurance group did 12 weeks, three sessions per week endurance training with 60 % of maximal heart rate and two session resistance training with 70 % 1-RM. Intense interval training group did three session/week of 4-10 repetition of all out 30s Wingate on ergometer were included 10 weeks of concurrent resistance- endurance training and intense interval training.
Results: The results showed that following sprint training, there were significant changes in hs-CRP (p<0.001), but it wasn’t significant following concurrent training (p=0.062). According to results, TNF-α change were not significant in intense sprint (p=0.11) and concurrent training (p=0.23). Differences were not significant for the fasting blood glucose in the intense interval training groups (p=0.000). Serum insulin levels showed significant increases in the SIT (p<0.000) and concurrent training (p=0.000) significantly. The data showed significant differences in insulin resistance index (HOMA-IR) in intense interval training (p=0.000) and concurrent resistance- endurance training (p=0.008). ANCOVA test showed no significant difference in fasting blood glucose concentrations (P=0.171).
Conclusion: Intense sprint training compare to concurrent strength-endurance training can have better inflammatory status for patients with type 2diabete.
Gholamreza Jafari Nadoushan, Hossein Hadinedoushan, Nasim Namiranian, Saeed Rezaei,
Volume 18, Issue 5 (7-2019)
Abstract
Background: Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum level of chitinase-3 like 1 protein (YKL-40) and high-sensitive C-reactive protein (hs-CRP) in type 2 diabetes with coronary artery disease compared to diabetic and healthy control.
Methods: This cross-sectional study was performed on 87 subjects in four groups, including: 23 samples as healthy control (Group 1), 22 patients with type 2 diabetes (Group 2), 20 patients with coronary artery disease (Group 3) and 22 patients with type 2 diabetes and coronary artery disease (Group 4). Serum Fasting blood sugar (FBS), Cholesterol, Triglyceride, Low density lipoprotein (LDL-C), High density lipoprotein (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), YKL-40 and hs-CRP were determined.
Results: The mean serum levels of FBS (Group 1 with 2 and 4, Group 2 and 3, P = 0.001), Cholesterol (Group 1 and 3, P = 0.03), Triglyceride (Group 2 and 3,p=0.027), HDL-C (Group 1 with 3 and 4, P = 0.02, P = 0.01 respectively), ALT (Group 1 and 4, P = 0.03, Group 2 and 4, P = 0.02) and AST (Group 2 and 4, P = 0.009) were significantly different..The mean serum levels of YKL-40 were significantly difference in the group 1(4.81±1.27 ng/ml) and group 2 (15.52±4.61 ng/ml) (P=0.01), group 3 (19.2±2.75 ng/ml, P=0.017) and group 4 (16.1±4.17 ng/ml, P=0.04). Also, The mean serum levels of hs-CRP in the group 3 (4.49± 1.53 μg/ml) and group 4 (1.28 ± 0.43 μg/ml) was significantly difference (P= 0.028).
Conclusion: Serum levels of YKL-40 are increased in people with type 2 diabetes and coronary artery disease. It is recommended to determine the serum level of this marker in these patients.
