Showing 5 results for Cancer
R Nabizadeh, Sh Salehi, M Younesian, K Naddafi,
Volume 2, Issue 4 (3-2010)
Abstract
Backgrounds and Objectives:Skin cancer is the most frequent malignancy in Iran. Exposure to the excessive ultraviolet radiation is an important factor in creating skin tumors. The purpose of this study is to determine how the ultraviolet index has been distributed in all townships throughout the country, to determine different kinds of skin cancer and to evaluate a geographical distribution of skin cancers with regard to the UV geographical distribution.
Materials and Methods: This study is ecologic, descriptive and analytical in nature. A total number of 6921 skin cancer cases registered at the Center for Disease Control of Iran in 2004 were thoroughly analyzed and UV data were collected from the world wide web. With the help of ArcGIS software and SPSS, the statistical analysis was done.
Results:The incidence rates were 10.13 for the total skin cancer, 7.53 for basal cell carcinoma, 1.79 for squamous cell carcinoma and 0.39 for malignant melanoma per 100000 population of Iran. The mean ultraviolet index differed from 9 in July to 3 in January. The correlation between the skin cancer incidence at the level of districts and ultraviolet index was not significantly observed.
Conclusion:Skin cancer is a public health problem in Iran. Further research in this regard would lead to skin cancer registration improvement and more understanding of different climatic, cultural and behavioral factors in developing skin tumors. With this knowledge the possibility of more effective prevention of the most prevalent cancer in Iran can be created.
M Moradi Baseri, H Kamani, Sd Ashrafi, E Bazrafshan, F Kord Mostafapour,
Volume 11, Issue 3 (12-2018)
Abstract
Background and Objective: Street dust is an important factor in urban pollution which consists of soil, particulate matters and heavy metals. At present, over half of the world’s population lives in urban areas. Therefore, this study aimed to investigate health risks of heavy metals in street dusts in Zahedan.
Materials and Methods: The samples of street dust were collected in Zahedan. After preparation, the samples, were injected to ICP-MS for determination the amount of Hg and Cu. According to the measured concentrations, Hazard quotient (HQ) and hazard index (HI) were calculated to evaluate the health risk assessment.
Results: Results showed that Hazard quotient for both Hg and Cu was less than 1 for children and adult. HQ for Hg and Cu was in order of HQingestion >HQdermal >HQinhalation> HQvapour for adults and HQvapour > HQingestion > HQdermal > HQinhalation for children. HI was also less than 1.
Conclusion: The value of HQ showed that inhalation of mercury vapor and ingestion were the main routes of exposure to Hg for children and adults. The non-carcinogenic risk was within the safe value (HI <1) in this study.
H Hassanvand, N Dehghan, K Naddafi, Ms Hassanvand, R Nabizadeh, S Faridi, Z Yousefi,
Volume 11, Issue 4 (3-2019)
Abstract
Background and Objective: Radon gas is one of the environmental risk factors which can increase the risk of lung cancer and it is well known as the second-leading cause of lung cancer after smoking. The aim of the present study was to investigate indoor radon gas concentration in residential and public environments of Nourabad Mammasani city and to estimate the effective dose due to radon exposure.
Materials and Methods: In this study, 52 homes and 8 public places were investigated to measure the concentration of indoor radon gas. Indoor radon concentrations were measured using passive sampling approach, alpha-track detectors (CR-39) for three months, and after that, detectors were sent to the laboratory to count the number of tracks.
Results: The results of this research showed that the average radon concentration (± SD) in the homes and public places was 42.4(±14.7) and 32.9(±20.1) Bq/m3, respectively. All radon concentration values were lower than the US Environmental Protection Agency standard and WHO guideline. The average of annual effective dose due to the radon exposure in homes was estimated to be 1.07 mSv. The evaluation of the results showed that there was a significant relationship between the room type and the number of floors with radon concentration in the residential buildings.
Conclusion: The results indicated that the indoor radon concentration as an environmental risk factor in the studied places was lower than the WHO guideline levels. Consequently, the indoor radon is not likely a major environmental risk factor in the studied environments.
A Jonidi Jafari, F Ghorbannezhad, A Rastegar,
Volume 12, Issue 2 (9-2019)
Abstract
Background and Objective: Humans are always exposed to ionizing radiation that could potentially have harmful effects. The aim of this study was to evaluate the background gamma dose rate, the estimated annual effective dose, and the excess cancer risk assessment in Dargaz.
Materials and Methods: This study was a cross sectional study which was conducted in January- March and July – September 2016. In this study, 5 stations (4 in the main geographical directions and 1 in the center city) were selected based on the map of the city to determine the dose rate of background gamma radiation in outdoor areas. A dosimeter was used (Geiger Müller detector STEP OD-02 with sensitivity of 0-2000 mSv/h) to measure gamma rays. The device was designed to monitore X-rays, gamma rays and beta rays.
Results: The results showed that the maximum and minimum mean values of background gamma dose rate were 147±12 nSv/h and 113±11 nSv/h in the center and west-direction of the city, respectively. The annual effective dose for Dargaz residents in outdoor was determined to be 0/15 mSv/yr, and the amount of excess lifetime cancer risk was estimated as 0.6×10-3.
Conclusion: The results indicated that there are significant differences between the rates dose in the center and other parts of the city (p≤0.05).
Parisa Farahmandian, Abdollah Mohammadian-Hafshejani, Abdolmajid Fadaei, Ramezan Sadeghi,
Volume 16, Issue 2 (9-2023)
Abstract
Background and Objective: Breast cancer is the most common malignancy in women worldwide. Cadmium is one of the most persistent and toxic heavy metals, exposure to which may lead to an increased risk of breast cancer. This study aims to quantitatively summarize the available evidence for the relationship between cadmium exposure and the risk of breast cancer using a systematic review and meta-analysis.
Materials and Methods: In this research, observational studies that investigated the relationship between cadmium and breast cancer until May 2022 and were published in international databases were searched and retrieved. To determine the heterogeneity, the statistical tests Chi2 and I2 were used, to determine the presence of publication bias Egger's and Begg's tests were used, and to detect the root of the heterogeneity, meta-regression, and sensitivity analysis were used.
Results: In this study, it was observed that compared to the base group, the relative risk of breast cancer in people exposed/exposed to a dose higher than the base level of cadmium is equal to 1.10 (95% CI: 1.06-1.14; p ≤ 0.001), therefore, a statistically significant relationship was observed between exposure to cadmium or exposure to levels exceeding the baseline and developing breast cancer. In investigating the possibility of publication bias, the result of Egger's test was equal to (p ≥ 0.001), and the result of Bagg's test was equal to (p = 0.099).
Conclusion: According to the available evidence, exposure to cadmium leads to an increase in the risk of breast cancer, and this increase in risk is statistically significant.
