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Showing 3 results for Relative Risk

Gholamreza Goudarzi, Mohamadjavad Mohammadi, Kambiz Ahmadi Angali, Basir Mohammadi, Zahra Soleimani, Aliakbar Babaei, Abdolkazem Neisi, Sahar Geravandi,
Volume 6, Issue 1 (5-2013)
Abstract

Background and Objectives: According to the WHO estimates, air pollution is accounted for about 800000 premature death of cardiovascular and respiratory disease and lung cancer resulted from air pollution throughout the world approximately 150000 cases of those deaths occur in south Asia. The studies conducting on short-term and long-term effects are reported in terms of admission rate, consulting with a physician, number of a particular disease, death, and years of the lost life (YOLL). We used Air Q2.2.3 (Air Quality Health Impact Assessment) Model to evaluate adverse health effects caused by NO2 exposure in Ahvaz City during 2009. NO2 reacts with ammonia, moisture, and other compounds to form small particles. These small particles penetrate deeply into sensitive parts of the lungs and can cause or worsen respiratory disease, such as emphysema and bronchitis, and can aggravate existing heart disease, leading to increased hospital admissions and premature death.
Materials and Methods: First the data required was collected from Ahvaz Environment Organization and Meteorological Organization. Then, this data were processed by Excel software through correcting temperature and pressure, coding, averaging and filtering. Finally, the data processed were entered to Air Q model. This model is a valid and reliable WHO-proved tool to estimate the potential short term effects of air pollution. This model includes four screen inputs (Supplier, AQ data, Location, Parameter) and two output screens (Table and Graph).
Results: It was found that the Meteorological and Environment Organization stations have had the maximum and minimum NO2 concentration respectively. Moreover, the annual, summer, and winter average and 98cile of this pollutant was 27, 6, 43, and 115 µg/m3 respectively. The cumulative number of myocardial infarction resulted from NO2 exposure was estimated to be nine persons per year. This value for the cardiovascular death was found to be 19 cases. Finally, the COPD cases was estimated to be seven per year.
Conclusion: Air Q software calculated relative risks, attributable proportion, and baseline incidence using data processed by Excel and presents the output as the cause specific deaths. It is noteworthy that there is no model that can estimate all of the pollutants health effects simultaneously. Cumulative number of persons for acute MI attributed to NO2 exposure was 9 in 2009. Moreover, 51% of this number occurred in the days with concentrations lower than 60 µg/m3. It should be noted that 72% of this value are corresponded to the days with concentrations below 90 µg/m3. The total cumulative number of cardiovascular death attributed to exposure with NO2 during one year of monitoring was 19 persons. 60% of these cases have occurred in days with NO2 levels not exceeding 90 µg/m3. Cumulative number of hospital admission of COPD attributed to exposure with NO2 during one year of monitoring was 7 persons.87 % of these cases have occurred in days with NO2 levels not exceeding 110 µg/m3.


Gh. Goudarzi, S Geravandi, S Saeidimehr, M.j. Mohammadi, M Vosoughi Niri, Sh. Salmanzadeh, K Ahmadi Angali, A.k. Neisi, A.a. Babaei,
Volume 8, Issue 1 (8-2015)
Abstract

Background and Objectives: According to the estimates of W.H.O., approximately 150000 persons are annually affected by early death of cardiovascular, respiratory disease, and lung cancer resulted from air pollution in south Asia. The short-term and long-term effects are reported as hospital admission, consulting with a physician, number of special disease, death and years of life lost (YOLL). The purpose of this paper is to discuss the effects of PM10 pollution on human health. AirQ 2.2.3 (Air Quality Health Impact Assessment) Model was used to evaluate adverse health effects caused by PM10 exposure in Ahvaz during 2009. Long-term exposure with suspended particulates are expressed as decreasing personal life. The prevalence of bronchitis and reduced lung function in children and adults, even at annual average concentrations of particulate matter below 20 µg/m3 (PM2.5) and 30 µg/m3 (PM10) have been observed. Major sources of emissions resulting from human intervention in particulate matter are road traffic (25-10%), stationary combustion (55-40%), and industrial processes (30-15%). Materials and Methods: First, PM10 data was collected from Ahvaz Environment Protection Organization and Meteorological Organization. Then, raw data were processed by Excel software.. Finally, data processed were inputted to AirQ model. This model proved to be a valid and reliable tool to estimate the potential short-term effects of air pollution. This software is provided by the World Health Organization and is used to quantify the health effects of air pollution. This model consists of four input screens (Supplier, AQ data, Location, Parameter) and two output screens (Table, Graph). Results: The highest and lowest PM10 concentration was reported for Headquarter and Naderi stations respectively. Moreover, the annual, summer, and winter means and 98 decimal of this pollutant in Ahvaz City was measured as 261, 376, 170, and 1268 µg/m3 respectively. Total death toll contributed to PM10 was estimated as 1165 cases in 2009. Conclusion: Using data processing in Excel, AirQ software calculates relative risks, attributable proportion, and baseline incidence and the final output would be displayed in the form of death toll. It is noteworthy that there is no model that can estimate the effect of all pollutants together and simultaneously. In addition, it was found that the annual PM10 emission mean, the summer mean, winter mean, and 98 percentile were 261, 376, 170, and 1268 µg/m3 in Ahvaz City. Cumulative number of persons for total number of deaths attributed to PM10 exposure was 1165 in 2009 Out of which, 44% has occurred in the days with concentrations lower than 250 µg/m3. It should be noted that 62% of this value is corresponded to the days with concentrations below 350 µg/m3. The total cumulative number of cardiovascular death attributed to the exposure with PM10 during one year of monitoring was 612 persons. On the other hand, 52% of these cases have occurred in days with PM10 levels not exceeding 300 µg/m3. Cumulative number of Hospital Admissions Respiratory Disease attributed to exposure with PM10 during one year of monitoring was 1551 persons Out of which, 36 % occurred in days with PM10 levels not exceeding 200 µg/m3.


Parisa Farahmandian, Abdollah Mohammadian-Hafshejani, Abdolmajid Fadaei, Ramezan Sadeghi,
Volume 16, Issue 2 (9-2023)
Abstract

Background and Objective: Breast cancer is the most common malignancy in women worldwide. Cadmium is one of the most persistent and toxic heavy metals, exposure to which may lead to an increased risk of breast cancer. This study aims to quantitatively summarize the available evidence for the relationship between cadmium exposure and the risk of breast cancer using a systematic review and meta-analysis.
Materials and Methods: In this research, observational studies that investigated the relationship between cadmium and breast cancer until May 2022 and were published in international databases were searched and retrieved. To determine the heterogeneity, the statistical tests Chi2 and I2 were used, to determine the presence of publication bias Egger's and Begg's tests were used, and to detect the root of the heterogeneity, meta-regression, and sensitivity analysis were used.
Results: In this study, it was observed that compared to the base group, the relative risk of breast cancer in people exposed/exposed to a dose higher than the base level of cadmium is equal to 1.10 (95% CI: 1.06-1.14; p ≤ 0.001), therefore, a statistically significant relationship was observed between exposure to cadmium or exposure to levels exceeding the baseline and developing breast cancer. In investigating the possibility of publication bias, the result of Egger's test was equal to (p ≥ 0.001), and the result of Bagg's test was equal to (p = 0.099).
Conclusion: According to the available evidence, exposure to cadmium leads to an increase in the risk of breast cancer, and this increase in risk is statistically significant.
 


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