Entrepreneurship and the creation of knowledge-based wealth during the past years are considerable issues in scientific and executive institutions, including health institutions. the present study aimed to design course topics to empower medical professionals to have an effective role in the innovation, technology, and knowledge-based ecosystem. This study was conducted using the scoping review method. After determining the research questions, a wide range of studies were investigated systematically and then a snowball search was performed to identify more relevant studies. In the next step, the most relevant data were extracted and then categorized and arranged according to the needs, and finally, the results were summarized as descriptive and inferential statistics tables. The data were coded and analyzed in pairs. Ultimately, the areas and course topics of the entrepreneurship curriculum were extracted and arranged as a suggested list. Then, the expert panel method was used to agree on the course topics and develop educational goals. In this study, 52 essential competencies were identified for medical professionals to have an effective role in the innovation, technology, and knowledge-based ecosystem. These competencies were categorized as 17 course topics and 3 categories including motivation, entrepreneurial knowledge and skills, and business knowledge and skills. Providing the necessary training to develop a comprehensive view of the opportunities and needs in society as well as the knowledge-based business environment is one of the basic concepts that should be included alongside entrepreneurship and business.
