Communication with patients is an important issue in nursing meaning that to realize the truth from their viewpoints. This study was performed to compare levels of nurses’ empathy with patients at drug abuse treatment centers (DATCs) and the internal ward of hospital. The present research was a cross-sectional and descriptive-analytic study conducted at two environments of the internal ward and DATCs. A total of 60 subjects comprised research participants and were listed in the study through census method. A two-part scale was used including personal information and Jefferson scale of empathy with verified validity and reliability. Data were analyzed using SPSS16 software. The scores of nurses' empathy with patients recorded in the internal ward and at DATCs were 67.84±6.32 and 79.73±9.21 (out of 100), respectively (P=0.001). Male nurses (76.80±9.88), married nurses (75.93±9.98), ages of >40 years (79.1±11.12), masters’ degrees (75.5±3.78), job experiences of >10 years (83.53±8.53) and overtime hours of <50 h (80.61±9.9) attained the highest empathy scores with significant differences (P<0.05). The scores of nurses’ empathy with drug-dependent patients at DATCs were higher than those of internal wards indicating that the care of addicted patients in a specialized ward leads to increased empathy. Considering the relationship between
empathic communication, educational levels and occupational experience of nurses, it is essential to consider training empathy skills to nursing students from the first semester and to provide in-service training to nurses working at hospitals and centers by nurses of higher educational qualifications and experiences.