Volume 15, Issue 2 (Vol.15, No.2 2019)
irje 2019, 15(2): 188-194 |
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Amiri F, Sharifi H, Ghorbani E, Mirrashidi F, Mirzaee M, Nasiri N. Prevalence of Congenital Hypothyroidism and Some Related Factors in Newborn Infants in Southern Kerman from April to March 2009. irje 2019; 15 (2) :188-194
URL: http://irje.tums.ac.ir/article-1-6347-en.html
URL: http://irje.tums.ac.ir/article-1-6347-en.html
1- Doctor of Medicine, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
2- Associate Prof., of Epidemiology, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
3- Instructor of Hematology and Blood Banking ,Jiroft University of Medical Sciences, Jiroft, Iran
4- Assistant Professor of Pediatrics and Endocrinologist, Department of Pediatrics, School of Medical, Jiroft University of Medical Sciences, Jiroft, Iran
5- Assistant Professor of Obstetrics and Gynecology,School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
6- Instructor of Epidemiology, School of Public Health, Jiroft University of Medical Sciences, Jiroft, Iran ,nasiri.epi@gmail.com
2- Associate Prof., of Epidemiology, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
3- Instructor of Hematology and Blood Banking ,Jiroft University of Medical Sciences, Jiroft, Iran
4- Assistant Professor of Pediatrics and Endocrinologist, Department of Pediatrics, School of Medical, Jiroft University of Medical Sciences, Jiroft, Iran
5- Assistant Professor of Obstetrics and Gynecology,School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
6- Instructor of Epidemiology, School of Public Health, Jiroft University of Medical Sciences, Jiroft, Iran ,
Abstract: (4760 Views)
Background and Objectives: Congenital hypothyroidism is one of the reasons for mental retardation and premature death of infants. Since identification of the determinants of hypothyroidism plays a significant role in its prevention, this study was conducted to determine the prevalence of congenital hypothyroidism and to investigate its determinants in newborn infants.
Methods: This study was a secondary analysis of the data of the neonatal congenital hypothyroidism screening program. Hypothyroidism was diagnosed based on the Thyroid Stimulating Hormone (TSH) level in the heel prick blood samples on the third to fifth day of life. The data of infants born in Jiroft hospitals were collected from Jiroft Health Center and analyzed using descriptive statistics and Poisson regression test.
Results: In this study, 4998 newborns (2450, 49.02% female, 2548, 98 / 50% male) were investigated. The study samples were newborns born from March to March 2016. The prevalence of congenital hypothyroidism was 1 in 135 live births. The prevalence of congenital hypothyroidism was higher in babies born by cesarean section (IRR = 2.2, 95% CI =1.1-4.1), newborns admitted to the NICU (IRR = 4.6, 95% CI=2.4-8.9), and babies with high birth weight (IRR = 5.3, 95% CI =3.5-8.1).
Conclusion: The prevalence of hypothyroidism was higher in this study compared to other studies. Its prevalence was higher in males than in females. Genetic and environmental differences may explain this difference. The prevalence of hypothyroidism was higher in infants born through cesarean section and newborns hospitalized in NICU.
Methods: This study was a secondary analysis of the data of the neonatal congenital hypothyroidism screening program. Hypothyroidism was diagnosed based on the Thyroid Stimulating Hormone (TSH) level in the heel prick blood samples on the third to fifth day of life. The data of infants born in Jiroft hospitals were collected from Jiroft Health Center and analyzed using descriptive statistics and Poisson regression test.
Results: In this study, 4998 newborns (2450, 49.02% female, 2548, 98 / 50% male) were investigated. The study samples were newborns born from March to March 2016. The prevalence of congenital hypothyroidism was 1 in 135 live births. The prevalence of congenital hypothyroidism was higher in babies born by cesarean section (IRR = 2.2, 95% CI =1.1-4.1), newborns admitted to the NICU (IRR = 4.6, 95% CI=2.4-8.9), and babies with high birth weight (IRR = 5.3, 95% CI =3.5-8.1).
Conclusion: The prevalence of hypothyroidism was higher in this study compared to other studies. Its prevalence was higher in males than in females. Genetic and environmental differences may explain this difference. The prevalence of hypothyroidism was higher in infants born through cesarean section and newborns hospitalized in NICU.
Type of Study: Research |
Subject:
Epidemiology
Received: 2019/10/15 | Accepted: 2019/10/15 | Published: 2019/10/15
Received: 2019/10/15 | Accepted: 2019/10/15 | Published: 2019/10/15
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