H Lashkardoost, B Zeighami, M Mahmoudi, J Hassanzadeh, A Hamedi, Hr Tabatabaee, F Sameemanesh, Sm Kashfi,
Volume 6, Issue 1 (20 2010)
Abstract
Background & Objective: Because of uncertainty in interpretation of some tests for diagnosing TB, decision making for the tuberculosis treatment is based on multiple diagnostic tests. This study was conducted to assess the accuracy of Quanti FERON-TB Gold test in tuberculosis diagnosis.
Methods: The study was carried out on 30 cases and 46 controls. Statistical indices of sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios, odds ratio and Receiver Operating Characteristics (ROC) curve were estimated.
Results: Sensitivity of QFT-G was 90.0% (95% CI=73.0-97.6), specificity 95.7% (95% CI=83.8-99.3), positive predictive value 93.1% (95% CI=76.3-98.9), negative predictive value 93.6% (95% CI=81.3-98.4). The area under ROC curve was 0.942 (95% CI=0.88-1.00), that significantly differed from chance diagonal area (P<0.0001). The optimum cut point for the Quanti FERON-TB Gold test was 0.35 IU/ml, with sensitivity of 0.90 and specificity of 0.957.
Conclusions: The Quanti FERON-TB Gold test displayed good validity indices in this study. Since the utility of this test has a high cost therefore this test would not be offered for routine tuberculosis detection. It suggested that this test are applicable for smear and culture negative tuberculosis, child tuberculosis, and assessment of TB contact tracing.
H Tavakoli Ghouchani, A Delshad, Hr Shoraka, H Lashkardoost, A Afshari Safavi , J Rahimi,
Volume 16, Issue 5 (Vol 16, Special Issue 2021)
Abstract
Background and Objectives: The COVID-19 pandemic has led to major health and socioeconomic problems worldwide. This study was conducted to determine the clinical features and health behaviors related to COVID-19 in patients presenting to selected COVID-19 centers of North Khorasan University of Medical Sciences.
Methods: This cross-sectional study was carried out using stratified random sampling in 350 patients presenting to selected COVID-19 centers of North Khorasan University of Medical Sciences in August and September 2020. Demographic and clinical features and the data related to COVID-19 disease were collected using a researcher-made checklist and analyzed with the SPSS 24 software using chi-square test and logistic regression.
Results: Of 350 patients, 200 (57.1%) were male and the rest were female. The PCR test was positive in 72% of the patients. The highest percentage of infection was seen in self-employed subjects and driver, people in the age group 30-50 years, and male subjects. The highest observance of masking, hand washing, and social distancing was related to healthcare staff and the lowest was seen in self-employed people, drivers, and military staff. A history of attending a gas station increased the chance of a positive test by 2.3 times (95% CI: 1.13-4.79).
Conclusion: According to the results, age, gender, occupation and history of presence in crowded places are important determinants of infection and adherence to protocols.
