Iranian Journal of

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Background and Objectives: A significant portion of the total health expenditure is related to medicines. Evaluation of medication system indicators forms a basis for modifying the consumption pattern and cost containment. Therefore, the present study was conducted to investigate the trend of medication consumption indicators in Iran.
Methods: In this descriptive-cross-sectional study, medicine consumption per capita was calculated based on the medicine type, medicine form, and treatment category. The data were extracted from the Pharmacological Statistics of the Food and Drug Administration and the Statistics Center of Iran between 2012 and 2015. Catzung categorization was used for treatment categories. Data were analyzed using descriptive statistics and annual growth index by Excel 2013 software.
Results: During the study years, the highest medicine consumption per capita was related to metformin 500 (18.52), ranitidine 150 (15.45), and adult cold (15.29). The highest average consumption per capita in different treatment categories was related cardiac medications (97.65). The lowest and highest growth rates were related to glibenclamide 80 with -12% in 2014 and metformin 500 with 16.9% in 2013, respectively. Tablets were the most widely used form of medicine.
Conclusion: According to the results, medicine consumption per capita in Iran is higher than developed countries. Cardiac and diabetes medications have a high consumption per capita in Iran compared to other medications. Therefore, in order to rationalize drug prescription, strengthening the clinical evaluation system is recommended by developing and implementing clinical guidelines for common and high-cost diseases.

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Background and Objectives: Access to equal educational opportunities is one of the fundamental rights in each country, and elimination of inequalities, especially in the higher education system, is one of the most important priorities. This study aimed to measure educational inequality in the medical sciences sector in Iranian provinces.
Methods: In this study, educational inequality in medical sciences was measured using the Gini coefficient. The study indexes included the number of students, faculty members, staff, majors and educational budget. Data were analyzed using Stata 14 software.
Results: During the study years, the Gini coefficient of the number of female students, male students, and faculty members showed a more or less decreasing trend from 0.51 to 0.46, from 0.53 to 0.46, and from 0.59 to 0.53, respectively. However, the values of inequality in the number of personnel working in educational sector and educational budget showed a slight increasing trend from 0.49 to 0.50 and from 0.53 to 0.54, respectively. According to the academic majors, the lowest Gini coefficient was related to non-continuous bachelor’s degree that varied from 0.13 to 0.17, and the highest value was related to fellowship degree ranging from 0.66 to 0.69 in the study years.    
Conclusion: Despite reduced inequality in some educational indicators, there is a high inequality in the number of academic majors of some postgraduate degrees, number of students by gender, and educational budget, which requires policy makers to focus more on balanced distribution of educational infrastructures among provinces to provide equal educational opportunities.

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Background and Objectives: Cholera is one of the public health ththat has received attention due to climate change and weather variables. In the current study, the trend of cholera and its epidemics was assessed in the last 50 years in Iran based on climatic variables.
Methods: In a retrospective cohort study, all cholera cases and epidemics of the disease in the country (Iran) were assessed using the registry system of the Center for Communicable Disease Control in the Ministry of Health and Medical education (MOH&ME) from 1964 to 2014. Furthermore, the incidence of cholera was evaluated in 2005-2014 by province. The temperature and rainfall data were obtained from the provincial Meteorological Organization. The correlation coefficient test and mixed-effects binomial regression model were used for data analysis.
Results: A significant positive correlation was found between cholera and rainfall (r = 0.168, P = 0.008). A one-millimeter increase in rainfall increased the incidence of cholera by 10.9% but temperature changes had no effect on cholera outbreaks. The incidence of cholera declined significantly by 14.7% each year from 2005 to 2014. The highest incidence of cholera was reported in Sistan-Baluchestan, Qom, Tehran, Kerman and Hormozgan provinces in a descending order.
Conclusion: In recent years, the the overall incidence of cholera has decreased. The occurrence of cholera is an outcome of rainfall in the previous year. Therefore, increased rainfall increases the number of cholera cases in the next year. However, temperature changes are not related to cholera outbreaks.

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Background and Objectives: Children’s well-being is a multidimensional construct that precedes various aspects of children's lives. This study sought to identify the main areas of children's wellbeing in Iran and their domains, components, and indicators that can be used to measure the well-being of children in Iran.
Methods: In this Delphi study, 30 experts that had educational, research, and executive experiences in various areas of children’s life were consulted. The dimensions, components, and indicators of children’s wellbeing were extracted through a review of the literature and views of the experts and children. The Delphi method was applied in three rounds. The dimensions and components with a higher-than-average score were selected and the percentage of Delphi members’ agreement with related indicators was measured.
Results: Generally, 25 components and 110 indicators related to 7 domains (physical health, safety and risks, economical situation, family, personal and social well-being, education, housing and living conditions) were selected by Delphi members. Consensus on the relevancy of indicators, proportionality, and comprehensiveness was 100%, 95%, and 86%, respectively.
Conclusion: The components and indicators suggested in this study can help to create a composite index for monitoring and comparing the status of the children’s wellbeing between different provinces of Iran in different times. It can also show the strengths and weaknesses of the policies and programs related to children’s wellbeing and help the government to adopt appropriate policies for the whole country as well as each province.

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Background and Objectives: Among non-communicable diseases, endocrine, nutritional, and metabolic diseases have increased in recent decades, especially in developing countries. This study was conducted to evaluate and predict deaths from this group of diseases in Iran
Methods: In this analytical cross-sectional study, the study population comprised all deaths of endocrine, nutritional, and metabolic diseases recorded in the Ministry of Health and Medical Education during the years 2006 to 2016. In order to forecast the trend of cause of death, the Lee Carter model was employed in the demographic package 18/1 of the R software version 3/3/1.
Results: The death rate from endocrine, nutritional, and metabolic diseases increased in all age and sex groups from 2006 to 2015. It was predicted that death rate of this group of diseases would reach 197/71 in 100,000 in the total population, 202/97 in 100,000 women, and 188/99 in 100,000 men in 2035.
Conclusion: Several factors play a role in endocrine and metabolic diseases, one of which is aging and aging population. Considering the change in the age structure of the population of Iran by 2035 and the increase in population’s age, an increasing trend is expected in the mortality rate due to these diseases. Because of this rapid increase, policymakers need to adopt intergovernmental population-based plans and policies in this regard.

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Background and Objectives: Life satisfaction is one of the important dimensions of health, which is influenced by health determinants. The aim of this study was to investigate the status of socioeconomic inequalities in satisfaction with life in women aged 15-54 in Iran.
 
Methods: In this cross-sectional study, randomized multistage cluster sampling with equal clusters was done to select the participants. A total of 35,305 women aged 15-55 were enrolled in the study. Data analysis was done in two stages. In the first stage, social and economic inequalities were investigated using the concentration index and concentration curve method. In the second stage, a multilevel method was used to identify the determinants.
 
Results: The mean life satisfaction was 12.81±4.23. The concentration index for dissatisfaction with life was -0.06 [95% CI: -0.1, -0.02], indicating dissatisfaction with life in low socioeconomic groups. The results of multilevel analysis showed that age, marital status, occupation, place of living, education, and the economic class correlated with dissatisfaction with life in women (P<0.05).
 
Conclusion: There is inequality in dissatisfaction with life. Dissatisfaction is concentrated in the poorer groups of the society and varies in different provinces. Socioeconomic variables affect inequality in satisfaction with life in women, which need to be addressed to reduce inequalities.

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Background and Objectives: Evaluation of the epidemiologic pattern of diseases requiring hospitalization is one of the effective factors in better management of hospitals, which can provide health managers and planners with a realistic and appropriate view on procuring the equipment and furnishing and equipping the hospitals in the country. This study was conducted to investigate this pattern based on the International Classification of Diseases (ICD-10) using the information recorded in Tehran Health Insurance Organization in a ten-year period.
 
Methods: In this descriptive research, we examined all records of hospitalized cases registered in the hospital information system of Tehran Health Insurance Organization during 2005 to 2014. The data of more than two million records, including case number, gender, and age of the patients as well as the diagnosis code were extracted from the hospital information system.
 
Results: From 2008859 cases, 51.9% of patients were male and the mean age of the patients was 24.60±44.22 years. In children less than one year, “certain conditions originating in the perinatal period”, in children aged one to four years “symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified”, in children 5 to 14 years “neoplasm”, in patients 15 to 44 years “pregnancy, childbirth and the puerperium”, and in patients above 45 years, “diseases of the circulatory system” were the most common diagnostic categories in hospitalized insured patients.
 
Conclusion: Due the specialization of diseases and various causes of hospitalization, to prevent wastage of financial and human resources, health policymakers and planners should allocate resources to insurance companies according to the scope of their activities.

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Background and Objectives: The sustainable development goals include 17 goals, one of which is exclusively related to health. The aim of this study was to assess the status of indicators of sustainable development goals related to health in Iran compared to countries in the region and the WHO countries.
 
Methods: Secondary data were used to examine the status of indicators of sustainable development goals related to health. The data reported by the World Health Organization in 2017, the World Bank, and other available resources at the international levels such as the UN and UNICEF were addressed. The indicators according to which the situation in Iran was below the average of the region were selected for further exploration and analysis. A checklist, which met the research objectives, was used for data collection.
 
Results: The status of the maternal mortality ratio (25 in 100,000 people), incidence of tuberculosis) 16 in 100,000 people), and incidence of malaria (0.5 in 1000 people) was favorable. The indicators with an unfavorable status in Iran compared to the regional average were the mortality due to natural disasters, unintentional poisoning, road traffic injuries, and alcohol consumption per capita.
 
Conclusion: Iran has achieved many SDGs goals; however, there is a need for carefully designed plans for controlling and reducing some indicators. Prioritizing indicators in which Iran has had little success should be taken seriously by decision makers.

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Background and Objectives: Satisfaction is a valuable measure of the quality of care and the patient-provider relationship. The Dental Satisfaction Questionnaire is a valid and international instrument for evaluating dental satisfaction. The aim of this study was to assess the validity and reliability of the Persian version of the Dental Satisfaction Questionnaire.
 
Methods: Upon assuring the precision of Persian translation, assessment of face and content validity was performed using the opinion of 10 patients and 10 experts. The validated questionnaire was then distributed among 300 patients attending the dental clinics using multistage cluster sampling. Factor analysis was used to assess the structure validity of the questionnaire and to elicit the factors predicting total satisfaction. Cronbach’s alpha was used for assessing the reliability of the questionnaire. 
 
Results: After some changes in some questions, the face and content validity of the questionnaire were confirmed. Factor analysis revealed 7 domains could determine 61.3% of total variance, including clinical quality, service quality, availability of care, pain management, cost, access, and empathy and responsiveness of dentists. Correlation of each domain with the total satisfaction was above 0.4. The mean satisfaction was 60.6 ±9.1. Cronbach’s alpha was 0.74.
 
Conclusion: The Persian version of the DSQ is a valid, reliable, and appropriate instrument for evaluation of dental satisfaction of Iranian population. The elicited domains could properly determine the total satisfaction.

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Background and Objectives: HPAI has economic and public health importance. Aquatic and shore migratory birds are the main reservoirs and the cause of the spread of viruses across countries. The aim of study was risk assessment of the spread of the avian influenza H5 viruses.
 
Methods: In this qualitative study, structured interviews and focus group discussions were used to assess the risk of the introduction and spread of highly pathogenic avian influenza viruses (H5-subtypes) into Iran.
 
Results: Over 300 wetlands, natural and artificial lakes, ponds, and more than 517 bird species (swans, geese, ducks, and coots) are identified in Iran. Weakness in detecting virus entry windows, weakness in passive surveillance of migratory birds, inadequate supervision on hunting of migratory wild birds, movement of  hunted birds without any criteria without the control of the Veterinary Organization, inability to monitor the supply of migratory birds in the LBMs, law weaknesses in dealing with offenders, lack of training for people, presence of suitable conditions for close contacts between wild birds and backyard and industrial poultry, and weakness of research on AI in migratory birds were the most important factors influencing the spread of these viruses.
 
Conclusion: HPAI will be one of the most important challenges for the poultry industry and public health.  Solving this challenge requires national determination, overhead organizational views, collaborative and practical cooperation of related organizations, and short and long-term planning based on the realities of the country.

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Background and Objectives: A considerable number of clinical trials are conducted in Iran each year. Not much is known about the characteristics of them, this study aimed to investigate key characteristics of Iranian clinical trials.
 
Methods: All clinical trial protocols registered in IRCT until November 2013 were selected. Text mining techniques were used to extract information from data that was mostly in the textual format. Stata software (v. 11) was used for both extraction and analysis.
 
Results: Totally 5049 trials where analyzed. Trials were in 40 different areas of medicine and their annual number was increasing. The sample size of registered trials was less than 70 in most trials and showed no significant improvement during the 5-year period (Median sample size= 64, inter quartile range (IQR) = 40-100). Phase III trials comprised 8.4% of the trials with a median sample size of 75 (IQR= 50-120). Of all phase III trials, 69% had a target sample size of less than 100. Most trials used randomization techniques (87.2%) but failed to use placebo (65.3%) and double/triple-blinding techniques (55.8%). The leading sponsors for 99.9% of trials were national bodies and 92.2% of the trials received public funds. Only 1% of the trials were exclusively sponsored by pharmaceutical companies.
 
Conclusion: The majority of clinical trials conducted in Iran are investigator-initiated and are funded by the public sector. The small sample size and failures in bias control observed in the majority of trials highlights the need for revising current policies of conducting trials in Iran.

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Background and Objectives: Leishmaniasis control in each country, especially in countries where the disease is endemic, requires designing and implementing an organized national surveillance system. Iran has long been considered as an endemic country for leishmaniasis. The purpose of this study was to review the leishmaniasis surveillance system in Iran.
 
Methods: In this review study, the data were obtained from the surveillance system, reports and documents, published guidelines, reviews of the existing structures, and the views of the managers and experts of the Center for Communicable Diseases control in Iran in 2018.
 
Results: The surveillance system for two types of leishmaniasis, cutaneous leishmaniasis and visceral leishmaniasis (Kala-azar), is currently operational in the country, and new cases are reported monthly. For each identified case, in addition to the epidemiologic attributes, treatment and follow-up as well as follow-up of possible contacts are done as per to the guidelines for each of these diseases.
 
Conclusion: The current surveillance system for leishmaniasis has improved the process of reporting cases in recent years. However, the low rate of reporting of cases, especially for cutaneous leishmaniasis, and epidemiological complexities in the transmission of the infection indicate the need for reviewing and improving the current surveillance system.  Data from the surveillance system and the increasing number of leishmaniasis cases in Iran reveal the need for innovations to strengthen the control measures for this disease.

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Background and Objectives: This article provides an overview of the national nosocomial infection surveillance system in Iran and its current status, achievements, and challenges.
 
Methods: All relevant reports, documents, and program guidelines, as well as published literature and surveillance data related to the nosocomial infection surveillance system in Iran were critically reviewed. Opinions of the key informants at local and governmental levels were also reviewed.
 
Results: The program was launched in 2006 covering 100 volunteer hospitals. Since 2016, participation in the program is obligatory, leading to the participation of 555 hospitals with >100 beds (56%). Major data collected in the program include demographic characteristics, infections and related risk factors, pathogens and their antimicrobial susceptibility/resistance, and patient outcome. Recently, device-associated infection rates are also calculated in the program. Since its establishment in 2006, the program has improved in terms of case finding and coverage. Implementation of the program has also had positive impacts on the stakeholders’ knowledge, attitude, and practice.
 
Conclusion: Although the number of identified cases and program coverage have improved, a considerable proportion of the infected cases still remain undiagnosed. Implementation of the program has also improved the stakeholders’ awareness, attitude and practice. The program faces a number of challenges, including lack of appropriate scientific support from academics and executive issues. Integration of active and sentinel surveillance in selected hospitals, persuasion of physicians to actively participate in the program, and conducting incidence and prevalence surveys would help the program to better detect nosocomial infection cases.

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Background and Objectives: Iran has long been considered to be one of the countries in the world with endemic brucellosis. The aim of this study was to review the surveillance system of brucellosis in Iran.
 
Methods: Data of this study were obtained from the surveillance system of the Center for Communicable Disease Control, the review of records, documents, books and published articles and also interviews with process owners and experts of brucellosis surveillance in 2017-2019.
 
Results: In the current surveillance system in Iran, all patients with brucellosis will undergo standard treatment for at least 2 months. The patient identified at each site, private or public sector, reports to the health center of the city. After reporting cases to higher levels, city health center carried out required epidemiologic investigation in the place of reported case in collaboration with its environmental levels. Finally, the individual assessment form, epidemiologic investigation form, for reported case is completed and registered in national surveillance database.
 
Conclusion: Although integration of the brucellosis surveillance program into the health system of the country and reporting and treatment of human cases in accordance with the country's protocol in recent years is well executed, brucellosis control in Iran requires the one health approach. Accordingly, it can be concluded that despite the decrease in the number of brucellosis cases in recent years, the weakness in livestock surveillance has led to many fluctuations in the health system's success in providing surveillance for human cases of brucellosis.

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Background and Objectives: One of the causes of neonatal death and death in children under the age of five is premature birth of infants. The purpose of this study was to identify the risk factors associated with preterm infant birth in pregnant women.
 
Methods: This is a case-control study on mothers referring to comprehensive health centers in the provinces of the country. Descriptive analysis of variables was reported as percentage and frequency. In data analysis, logistic regression analysis was used at a significant level less than 0.05.
 
Results: In this study, 2463 pregnant women (668 cases as cases and 1795 as controls) were examined. There was a significant relationship between the place of residence (OR=0.702, P=0.002), level of maternal education (OR=1.920, P=0.027), degree of twin (OR=4.953, P=0.001), interval between pregnancies (OR=1.821, P=0.009), specific disease (OR=1.694, P=0.010), nutritional status of the mother (OR=1.420, P=0.024), physical activity (OR=1.591, P=0.001), Sleep patterns (OR=0.634, P=0.008) and history of stillbirth (OR=0.247, P=0.001) associated with the birth of premature infants.
 
Conclusion: Preterm infant birth is one of the main causes of neonatal death. Therefore, some of the birth defects of the premature baby can be prevented. It is possible to reduce the risk factors for the birth of a premature baby by improving the quality of pregnancy care and changing the lifestyle of the pregnant mother, and by raising awareness and creating a healthy and safe environment for the mother.

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Background and Objectives: Iran is one of the Middle Eastern countries that implemented the HIV / AIDS control and surveillance program many years ago. The purpose of this study was to review the HIV / AIDS surveillance system in Iran.
 
Methods: This was a review research to assess the processes, structures and achievements of the HIV/AIDS surveillance system in Iran. The information sources of this study included data from the surveillance system, reports and documentation, and published guidelines, reviewing existing structures and views of managers and practitioners of the HIV/AIDS surveillance system in Iran.
 
Results: In Iran, all cases with HIV / AIDS as well as people with high risk behaviors are referred to behavioral disease counseling centers in order to receive health care services. Harm reduction in people with risky behaviors in the form of counseling centers, drug addicts' centers, and women's counseling centers in collaboration with governmental and non-governmental organizations, and attention to the second generation of HIV/AIDS surveillance, particularly conducting behavioral studies, are other components of the HIV / AIDS surveillance system in Iran
 
Conclusion: Although the HIV / AIDS surveillance system in Iran has a large structure with many achievements in reducing new HIV cases, especially in some high-risk groups such as injecting drug users, as well as reducing HIV transmission from infected mothers to their children, strengthening this surveillance system, especially for sexual high-risk groups, is essential for controlling HIV/AIDS in the country.

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Background and Objectives: Iran, like most other countries in the world, is always threatened with global epidemics and pandemics of influenza. The purpose of this study was to review the influenza surveillance system in Iran.
 
Methods: Data of this study were obtained from the surveillance system of the Center for Communicable Disease Control, the review of records, documents, books and published articles and also interviews with process owners and experts of influenza surveillance in 2017-2019.
 
Results: Influenza surveillance in Iran Currently, a combination of surveillance methods, including caring for patients, laboratory care, hospital care and surveillance of respiratory disease epidemics and also border surveillance. Reporting of human influenza outbreaks, as well as suspected avian flu as main notifiable diseases carried out through telephone. For each suspect case, in addition to taking and sending a sample to diagnose and also detect subtypes of the virus, medical treatment is immediately initiated and tracking of possible contacts is also done.
 
Conclusion: Although there is currently good coherence in the surveillance of influenza in Iran, but based on concerns about the emergence of influenza pandemics in the future, and considering the possible genetic variation of the flu viruses, the tracking of the flu virus circulation along with updating surveillance system especially emphasizing methods and formulas for rapid identification of disease outbreaks, as well as providing better health care and treatment is essential.

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Background and Objectives: Iran has carried out a series of surveys based on the Global school-based student health survey (GSHS) referred to as the CASPIAN. The aim of this paper was to compare the methodology and tools of CASPIAN surveys and to propose recommendations and suggestions for future implementations.
 
Methods: The data of this systematic review study were gathered from the World Health Organization (WHO) documentations, international databases including Pubmed, EMBASE, Scopus, GoogleScholar, and ScienceDirect, and national databases including Magiran, SID, and Irandoc. The search was conducted in both English and Persian (for the time period from 2003 to 2018). The time and place of the study, target population, questionnaire(s), sample size, and sampling method were compared between the surveys.
 
Results: Five rounds of CASPIAN survey were conducted in Iran from 2003 to 2015. The surveys had two sets of questionnaires for students and parents. In all five rounds, sampling methods and questionnaires were similar in the core and differed in some details that were added selectively in each round. The questionnaires were designed based on the GSHS and the WHO stepwise approach to non-communicable disease risk factor surveillance (STEPS) programs.
 
Conclusion: Considering the small variation in each series and compliance with the global model, it is suggested that the next CASPIAN survey be conducted according to the previous series in accordance with the standards presented in the global model in recent years in a reasonable interval from the 2015 survey.

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Background and Objectives: To provide an overview of the national program of Crimean-Congo hemorrhagic fever surveillance in Iran, its current achievements, and challenges.
 
Methods: In this mixed method study, the relevant reports, documents, and guidelines, as well as published literature and surveillance data were gathered and critically reviewed. The opinions of the key informants at local and governmental levels were assessed through structured interviews.
 
Results: The program was integrated into Iran’s primary healthcare (PHC) network in 1999. The involved organizations include CDC, medical universities, Pasteur Institute of Iran (PII), and Veterinary Organization. Case finding is based on standard definitions of suspected, probable, and confirmed cases. Laboratory confirmation is necessary for diagnosis and is provided within 48 hours after receipt of the specimen by the National Reference Laboratory of PII. CCHF treatment is primarily supportive. Antiviral therapy with ribavirin is also considered. Both therapeutic services are free. Education mainly focuses on high-risk groups and healthcare workers. Major achievements of the program include rapid diagnosis and treatment of cases, prevention of nosocomial transmission, identification of high-risk provinces and major transmission routes, improved outbreak preparedness, development of laboratory tests for detection of other arboviruses, and reduction of CCHF case fatality rate.
 
Conclusion: Program implementation has had a positive impact on early detection and proper control of annual outbreaks. However, some aspects of the program still need improvement, including promotion of the general and high-risk populations’ awareness and regional collaborations (especially among neighboring countries) for infection control in humans, livestock, and vectors.

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Background and Objectives: Iran started malaria elimination campaigns many years ago. The purpose of this study was to review the malaria surveillance system in Iran.
 
Methods: The data of this study were obtained from the surveillance system of the Center for Communicable Disease Control, a review of records, documents, books and published articles, and also interviews with process owners and experts of malaria surveillance in 2017-2019.
 
Results: The surveillance system of malaria in Iran has a coherent structure, in which all identified cases are reported and monitored from the environmental levels to the center by telephone instantly. Considering that the main goals of the malaria program including disease elimination have been obtained, the surveillance system in Iran is currently aiming at strengthening the elimination phase. In this stage, all new cases are also epidemiologically investigated in addition to examination, treatment and follow-up for categorization of the cases in categories of relapse, indigenous, introduced, and induced.
 
Conclusion: The successful implementation of the surveillance system for malaria over time has caused indigenous cases of disease to be limited to three southeastern provinces of the country and there are fewer than 300 new cases a year. Despite success, since the goal of malaria surveillance in Iran is now disease elimination, continuous monitoring of  correct implementation of all processes and evaluation of the applied strategies are necessary.