M Asghari Jafarabadi, E Hajizadeh, A Kazemnejad, Sr Fatemi,
Volume 6, Issue 3 (12-2010)
Abstract
Background & Objectives: Cholera is always being considered as a public health threat in poor and developing countries. However outbreaks of cholera are not very common in central area of Iran in 2008 district health authority reported a cluster of diarrhea cases. We investigated this cluster to identify the etiological agent, source of transmission and propose control measures.
Methods: We analyzed the data of total of 1219 patients with colorectal cancer who registered between 1 January 2002 to 1 October 2007. Data were analyzed using univariate and multivariate Accelerated Failure Time (AFT) parametric survival model with frailty, utilizing STATA statistical software.
Results: In the univariate analysis for age at diagnosis, gender, marital status, race and education level, the survival of patients with colon cancer were approximately between half to one fourth and for BMI, alcohol history, Inflammatory Bowel Disease (IBD), familial history of cancer and the pathologic stage of tumor, the survival of patients with colon cancer were significantly (between 0.12 to 0.56 times) shorter than those patients with rectal cancer. In the multivariate analysis, for age at diagnosis (45-65 years), there was significant difference between colon and rectum cancer. But for BMI, alcohol history, IBD and pathologic stage there were not significant differences. The adjusted survival and 1, 2, 3, 4 and 5 year survival of patients with rectal cancer were better than those with colon cancer.
Conclusions: Site-specific evaluation of colon and rectum could give a better perspective of factors affecting these cancers. It may help to design of clinical trials, better diagnosis of diseases and optimal administration of specific treatments.
Marzieh Gharanjiki, Abdolhalim Rajabi, Taghi Amiriani, Gholamreza Roshandel, Mohammadali Vakili,
Volume 21, Issue 2 (9-2025)
Abstract
Background and Objectives: Colorectal cancer is the most common gastrointestinal malignancy worldwide, and its incidence is increasing in Iran. Competing risk analysis offers a refined approach to identify factors influencing Colorectal cancer-specific mortality. Therefore, This study was designed and conducted to determine the survival of patients with colorectal cancer and its associated factors.
Methods: The study was a historical cohort. Data of patients diagnosed with colorectal cancer between 2013 and 2019 at Golestan University of Medical Sciences were collected, and patients were followed up until May 4, 2024. Patient survival was estimated, and the cumulative incidence function, as well as competing risk models of cause-specific hazards and subdistribution hazards, were applied for competing risk analysis. Model adequacy was assessed using the Akaike Information Criterion. Analyses were performed in STATA version 17 (α = 0.05).
Results: Of the 811 patients, 366 (45.13%) were women and the rest were men. The mean age and standard deviation were calculated as 58.54 ± 13.87 years. In the multivariable analysis of factors associated with colorectal cancer mortality in the presence of competing risks, variables including gender, age, literacy, ethnicity, and metastasis were statistically significant in both models. Findings indicated that the cause-specific hazard model provided a better fit for analyzing survival outcomes in colorectal cancer.
Conclusion: Competing risk analysis based on cause-specific hazards is recommended in the multivariable analysis of factors associated with colorectal cancer mortality, particularly in the presence of competing risks of death from other causes.
