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Showing 2 results for Familial Aggregation
Familial Aggregation of Coronary Heart Disease Risk Factors in Kerman Province
Aa Haghdoost, A Mirzazadeh,
Volume 2, Issue 1 (3-2006)
Abstract
Background & Objectives: There is no shortage of evidence linking coronary heart disease (CHD) to various genetic and environmental factors. Nonetheless, exploring the familial aggregation of major risk factors in the Iranian population could add valuable information to the existing body of knowledge.
Methods: We received data on 656 families (1614 individuals) from the Provincial Health Authority in Kerman. The data had been originally collected in a nationwide non-communicable disease control project, under the auspices of the Health Ministry's Public Health Department. In this study, we divided subjects into high- and low-risk groups based on the 75th percentiles of risk factor levels. Using a random-effect Poisson regression model, we looked at the association between risk factors within families. In all models, the risk ratios (RR) were adjusted for the age gap between parents and children.
Results: Excessive weight in children showed a stronger association with overweight in the father than with the same problem in the mother (RR: 2.35 versus 1.59). Risk of high blood pressure in the father was significantly related to the risk in the mother and the child. The risk of high blood glucose showed a significant association only between parents. Similarly, hypercholesterolemia did not show a significant association between parents and children, but its RR in parent-parent associations was around 2. We did not find any significant familial aggregation for smoking. However, physical exercise in mothers doubled the rate of exercise in other family members.
Conclusions: Although our sample size was relatively small, we found stronger associations within parent couples than between parents and children. This implies that common lifestyle may be a more prominent factor than genetic make-up.
Familial Aggregation of Alcohol Consumption and Associated Factors in East Azerbaijan Province: A Cross-Sectional Study
Elham Davtalab Esmaeil, Ali Hossein Zeinalzadeh, Leila R. Kalankesh, Alireza Ghaffari, Saeed Dastgiri,
Volume 20, Issue 2 (9-2024)
Abstract
Background and Objectives: The present study aimed to assess the prevalence and familial aggregation pattern of alcohol consumption among father-offspring, mother-offspring, siblings, and spouses in Tabriz city, and to investigate the associated risk factors.
Methods: This cross-sectional study was conducted in 2023 on 860 individuals in Tabriz city. The heads of households were selected as proband individuals. Conveniently, probands were recruited from daily visitors, and upon agreeing to participate, their first-degree relatives (spouse and children) were also invited to join in. Data were collected using standard self-reported questionnaires. Generalized Estimating Equations (GEE) were employed to assess family aggregation among father- offspring, mother-offspring, and siblings.
Results: No significant of familial aggregation alcohol consumption was observed between spouses (OR=0.54 (0.16-1.8)). Although familial aggregation was observed between mothers and children, this was not statistically significant (OR=1.54 (0.8-2.94)). There was a significant familial aggregation of alcohol consumption between fathers and children (OR=1.98 (1.08-2.5)). Among siblings, familial aggregation was not statistically significant (OR=1.38 (0.41-4.63)).
Conclusion: Based on the findings of this study, family members play an important role in influencing the alcohol consumption behaviors of other family members. Additionally, individuals with lower socioeconomic status, those who are divorced, and singles may be more appropriate targets for alcohol consumption screening programs.

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