Showing 5 results for Frailty
M Asghari Jafarabadi, E Hajizadeh, A Kazemnejad, Sr Fatemi,
Volume 6, Issue 3 (12-2010)
Abstract
Background & Objectives: Cholera is always being considered as a public health threat in poor and developing countries. However outbreaks of cholera are not very common in central area of Iran in 2008 district health authority reported a cluster of diarrhea cases. We investigated this cluster to identify the etiological agent, source of transmission and propose control measures.
Methods: We analyzed the data of total of 1219 patients with colorectal cancer who registered between 1 January 2002 to 1 October 2007. Data were analyzed using univariate and multivariate Accelerated Failure Time (AFT) parametric survival model with frailty, utilizing STATA statistical software.
Results: In the univariate analysis for age at diagnosis, gender, marital status, race and education level, the survival of patients with colon cancer were approximately between half to one fourth and for BMI, alcohol history, Inflammatory Bowel Disease (IBD), familial history of cancer and the pathologic stage of tumor, the survival of patients with colon cancer were significantly (between 0.12 to 0.56 times) shorter than those patients with rectal cancer. In the multivariate analysis, for age at diagnosis (45-65 years), there was significant difference between colon and rectum cancer. But for BMI, alcohol history, IBD and pathologic stage there were not significant differences. The adjusted survival and 1, 2, 3, 4 and 5 year survival of patients with rectal cancer were better than those with colon cancer.
Conclusions: Site-specific evaluation of colon and rectum could give a better perspective of factors affecting these cancers. It may help to design of clinical trials, better diagnosis of diseases and optimal administration of specific treatments.
A Saki Malehi , E Hajizadeh, K Ahmadi, P Mansouri,
Volume 10, Issue 1 (6-2014)
Abstract
Background and Objectives : The aim of this study was to assess the disease trajectory and recurrence rate of pemphigus based on the analysis of the gap time between successive recurrent events. In this regard, the most important associated factors with the risk of recurrence could be explained.
Methods: This longitudinal study was performed on 112 pemphigus patients who attended the dermatology department of Imam Khomeini Hospital, Tehran, Iran, from March 2006 to January 2013. The study duration was considered from the diagnosis of the disease to December 2013. Recurrent events were analyzed based on the gap time between successive events using the multivariate time dependent frailty model. The time between two recurrent gap times was determined monthly between two successive events.
Results : Decreasing the gap times between two successive events indicates that the subsequent event after the first recurrence occurs with shorter time intervals. So, the disease trajectory represents an increase in the recurrence rate over time. Based on the results of multivariate frailty model, IgG antibody's level was the only effective factor on the recurrence hazard rate of the patients. Also, this model proved that the frailty effects were time dependent frailties.
Conclusion: Assessing the disease trajectory and recurrence hazard rate can be achieved through analyzing the gap time between successive recurrent events. This analysis also identifies the factors that influence the risk of subsequent recurrent events.
A Bagheri, M Saadati,
Volume 15, Issue 1 (5-2019)
Abstract
Background and Objectives: One of the most important determinants of the fertility level is the birth interval. Considering the importance of this issue, the aim of this study was to analyze the first and second birth intervals using shared frailty survival model and comparing factors affecting these intervals.
Methods: Probability proportional to size stratified sampling was used to select 610 married women aged 15-49 years from different regions of Tehran during the winter and spring of 2017. Data were collected using a structured questionnaire. The shared frailty survival model was fitted to investigate the effect of calendar period, age at marriage, education level, education level of the spouse, job and migration status, household costs, and place of residence on first and second birth intervals.
Results: The median length of the first and second birth interval was 38 and 55 months, respectively. Calendar period had a significant effect on the first birth interval (p-value=0.016). Job status (p-value=0.045) and place of residence (p-value=0.025) had a significant effect on the second birth interval. The hazard rate of the first birth interval for women in the recent calendar period compared to women in the first period was equal to 0.448, and the hazard rate of the second birth interval for employed compared to unemployed, living in developed versus undeveloped regions was 0.812, and 0.724, respectively
Conclusion: Delayed childbearing among young women and longer second birth intervals in employed women may result from economic and social conditions that can be prevented by providing appropriate conditions.
F Osmani, E Hajizadeh, Aa Rasekhi, Me Akbari,
Volume 15, Issue 2 (9-2019)
Abstract
Background and Objectives: In many medical situations, people can experience recurrent events with a terminal event. If the terminal event is considered a censor in this type of data, the assumption of independence in the analysis of survival data may be violated. This study was conducted to investigate joint modeling of frequent events and a final event (death) in breast cancer patients using a frailty model.
Methods: In this retrospective cohort study, 443 patients with breast cancer registered at the Hospital of Shohadaye Tajrish Cancer Research Center were studied. The model of Liu (2004) was applied for joint modeling of recurrent events and a terminal event in which a shared frailty with gamma-distribution was used. Data modeling and data analysis were done using the R software.
Results: Four hundred and forty three women with breast cancer were studied. Univariate and multivariate analysis were performed in these patients. Of these, 338 cases (76.3%) had recurrence events, and 105 (23.7%) were censored. The obtained results of joint frailty model indicated that the relative risk of relapse in patients with a positive first-degree family history was 36% higher than that of other people (P<0.05). The relative risk of relapse in patients with stage 3 disease was 19% more than other stages and also the relative risk of relapse in patients with chemotherapy was 2.5 times higher than those without chemotherapy.
Conclusion: In this study, the presented model, in addition to simultaneous modeling capability of the event, could help prevent a higher prevalence of the terminal event (death) and thus reduce the adverse effects of reversible diseases.
Aysan Amrahi Tabieh, Parvin Sarbakhsh, Shamsedin Namjoo, Hossein Akbari, Hamid Allahverdipour,
Volume 19, Issue 4 (3-2024)
Abstract
Background and Objectives: Frailty syndrome significantly impacts the health of older adults, and sleep quality is likely a pertinent clinical factor. Therefore, this study aims to investigate the relationship between sleep quality and sleep duration with frailty syndrome in the older adults of Naqadeh City.
Methods: This cross-sectional study enrolled 347 older adults aged 60 years and above in Naqadeh city in 2020 using 2-stage sampling (first, stratified, and then simple random sampling. Data collection tools included demographic questionnaires, the Edmonton Frail Scale, and the Pittsburgh Sleep Quality Index. Statistical analysis was performed using SPSS25 software.
Results: The study revealed that 30.3% of older adults were frail. Furthermore, a statistically significant correlation was observed between sleep quality and duration with older adults' frailty (r=0.635, p<0.001 and r=-0.170, p<0.001, respectively). Additionally, all frailty domains exhibited a significant relationship with sleep quality, with the most notable associations found in mood, medication use, and cognition domains (r = 0.487, r = 0.397, r = 0.381, respectively).
Conclusion: Probably, the quality and duration of sleep affect the frailty syndrome, so it is necessary to design and implement effective interventions to improve the quality of sleep and ultimately reduce the frailty of older adults, especially in the domains of cognition and mood.
