D Khalili, F Hadaegh, M Tohidi, A Ghasemi, F Sheikholeslami, F Azizi,
Volume 4, Issue 3 (3-2009)
Abstract
Background & Objectives: Triglyceride/HDL-cholesterol ratio (TG/HDL-C) has been shown as an indicator for metabolic syndrome (MetS). This study aimed to detect the role of this ratio to predict coronary heart disease (CHD) outcome in an Iranian men population with high prevalence of MetS.
Methods: 1824 men ≥ 40 years old, free of clinical cardiovascular disease at baseline, were included in the study from February 1999 to August 2001. Serum level of total cholesterol (TC), HDL-C, TG, and risk factors of CHD including age, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, smoking and family history of cardiovascular diseases were measured at initial phase of study.
Results: During a median follow up of 6.5 years until March 2007, a total of 163 new CHD events occurred. According to a Cox proportional hazard modeling, after adjustment for TC and other risk factors, men in the top quartile of TG/HDL-C relative to first quartile had a significant hazard ratio (HR) of 1.85 (95% CI, 1.07-3.17). Combined HR for TC and TG/HDL-C (men in the top quartiles of both TC and TG/HDL-C relative to first quartiles) after adjustment for other risk factors was 6.13 (95% CI, 2.37-15.86).
Conclusions: The evaluation of both TG/HDL-C ratio and TC should be considered for CHD risk prediction in Iranian male population.
N Hosseinzadeh, Y Mehrabi, Ms Daneshpour, H Alavi Majd, F Azizi,
Volume 8, Issue 1 (7-2012)
Abstract
Background
& Objectives: Studying
several linked markers provides more information on locating disease genes
locus by using genetic association analysis.
The aims of this study were to introduce Multimarker Family Base Association
Tests (FBAT-MM) and its Linear Combination (FBAT-LC) in multimarker genetic
association analysis and to examine the association of selected microsatellites
with HDL-C in an Iranian population.
Methods: One hundred twenty five (125)
families having at least one member with metabolic syndrome and at least two
members with low HDL-C were selected from participants of the Tehran Lipid and
Glucose Study (TLGS). Multimarker genetic association of HDL-C level with some
microsatellites in the chromosomes 8, 11, 12, and 16 were examined using
FBAT-MM and FBAT-LC methods.
Results: The families consisted of 563
individuals (269 males and 294 females). FBAT-MM showed significant genetic
association only between HDL-C and three microsatellites in Chromosome 11 (P<0.05).
The microsatellite D11S1304 was found as the significant factor for multimarker
genetic association.
Conclusion:
FBAT-MM and FBAT-LC did not show shortcomings such as excessive conservatism
and low power which are, usually, observed in other multimarker methods. Finding microsatellites associated with HDL-C
level can provide background for further researches on the role of predisposing
genes in metabolic syndrome.
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