Showing 5 results for Metabolic Syndrome
D Khalili, F Hadaegh, M Tohidi, A Ghasemi, F Sheikholeslami, F Azizi,
Volume 4, Issue 3 (3-2009)
Abstract
Background & Objectives: Triglyceride/HDL-cholesterol ratio (TG/HDL-C) has been shown as an indicator for metabolic syndrome (MetS). This study aimed to detect the role of this ratio to predict coronary heart disease (CHD) outcome in an Iranian men population with high prevalence of MetS.
Methods: 1824 men ≥ 40 years old, free of clinical cardiovascular disease at baseline, were included in the study from February 1999 to August 2001. Serum level of total cholesterol (TC), HDL-C, TG, and risk factors of CHD including age, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, smoking and family history of cardiovascular diseases were measured at initial phase of study.
Results: During a median follow up of 6.5 years until March 2007, a total of 163 new CHD events occurred. According to a Cox proportional hazard modeling, after adjustment for TC and other risk factors, men in the top quartile of TG/HDL-C relative to first quartile had a significant hazard ratio (HR) of 1.85 (95% CI, 1.07-3.17). Combined HR for TC and TG/HDL-C (men in the top quartiles of both TC and TG/HDL-C relative to first quartiles) after adjustment for other risk factors was 6.13 (95% CI, 2.37-15.86).
Conclusions: The evaluation of both TG/HDL-C ratio and TC should be considered for CHD risk prediction in Iranian male population.
S Hosseinpour Niazi, P Mirmiran, G Sohrab, F Hosseini Esfahani, F Azizi,
Volume 7, Issue 4 (3-2012)
Abstract
Normal
0
false
false
false
EN-US
X-NONE
AR-SA
Background & Objectives: There is little known about the relation between metabolic
syndrome and fiber intake are available in Iran. We evaluated the relation
between total, and various types and sources of dietary fiber and the
prevalence of the metabolic syndrome.
Methods: In this cross sectional study, 2457
adults, aged 19-84 years were studied. Total dietary fiber intake and its types
and sources were assessed using a validated semi quantitative food-frequency
questionnaire. Blood pressure, Anthropometric, and biochemical measurements
were assessed. The metabolic syndrome was defined according to definition by
Iranian National Committee of Obesity.
Results: In the
multivariate-adjusted odds ratio, intakes of total (OR: 0.53 95% CI:
0.39-0.74), both soluble
(OR: 0.60 95% CI: 0.43-0.84) and insoluble dietary fiber (OR: 0.51 95% CI:
0.35-0.72), fruit fiber
(OR: 0.51 95% CI: 0.37-0.72), legume fiber (OR: 0.73 95% CI: 0.53-0.99) and
cereal fiber
(OR: 0.74 95% CI: 0.57-0.97) were inversely associated with the metabolic
syndrome. There was not significant association between using vegetable and nut
fiber and prevalence of metabolic syndrome.
Conclusion: Total
dietary fiber, both soluble and insoluble fibers, and especially fruit and
legumes fibers, reduce the metabolic syndrome among adults in Tehran.
N Hosseinzadeh, Y Mehrabi, Ms Daneshpour, H Alavi Majd, F Azizi,
Volume 8, Issue 1 (7-2012)
Abstract
Background
& Objectives: Studying
several linked markers provides more information on locating disease genes
locus by using genetic association analysis.
The aims of this study were to introduce Multimarker Family Base Association
Tests (FBAT-MM) and its Linear Combination (FBAT-LC) in multimarker genetic
association analysis and to examine the association of selected microsatellites
with HDL-C in an Iranian population.
Methods: One hundred twenty five (125)
families having at least one member with metabolic syndrome and at least two
members with low HDL-C were selected from participants of the Tehran Lipid and
Glucose Study (TLGS). Multimarker genetic association of HDL-C level with some
microsatellites in the chromosomes 8, 11, 12, and 16 were examined using
FBAT-MM and FBAT-LC methods.
Results: The families consisted of 563
individuals (269 males and 294 females). FBAT-MM showed significant genetic
association only between HDL-C and three microsatellites in Chromosome 11 (P<0.05).
The microsatellite D11S1304 was found as the significant factor for multimarker
genetic association.
Conclusion:
FBAT-MM and FBAT-LC did not show shortcomings such as excessive conservatism
and low power which are, usually, observed in other multimarker methods. Finding microsatellites associated with HDL-C
level can provide background for further researches on the role of predisposing
genes in metabolic syndrome.
Normal
Mh Panahi , P Yavari, D Khalili, Y Mehrabi, F Hadaegh, F Azizi,
Volume 9, Issue 4 (3-2014)
Abstract
Background & Objectives: We studied the risk of Chronic Kidney Disease (CKD), Metabolic Syndrome (MetS), and their interaction on the incidence of Coronary Heart Disease (CHD).
Methods: A population of 6568 participants (43.4% male) with a mean age of 48.4 years for males and 46.7 years for females and a median follow-up of 10.1 years was investigated. They were divided into 4 groups at baseline: CKD-/MetS-, CKD+/MetS-, CKD-/MetS+, CKD+/MetS+. Hazard Ratios (HRs) were calculated for each group and were compared to the first group using multivariate Cox regression analysis adjusted for age, education, smoking, total cholesterol, and the family history of cardiovascular diseases.
Results: Men with CKD (without MetS) showed an HR of 1.74 (CI 95%: 1.16-2.60) for CHD events. The measured value was 2.34 (1.77-3.08) for men with MetS (without CKD). The respective results were in women 1.18
(0.64-2.19) and 2.59 (1.73-3.88). CKD and MetS had a significant negative interaction with CHD events (HR=0.40, 0.24-0.66). The interaction was not significant in women (P value=0.48).
Conclusion: The results of this study indicated that CKD without MetS was a risk factor for coronary heart disease in men but not in women.
Mh Panahi, P Yavari, D Khalili, Y Mehrabi, F Hadaegh, F Azizi,
Volume 11, Issue 1 (6-2015)
Abstract
Background & Objectives: Some studies on chronic diseases have indicated that obesity may result in a paradoxically longer survival. The present study was aimed to investigate the effect of Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS) on the incidence of Coronary Heart Disease (CHD).
Methods: In order to record time to CHD events, a sample of 6,507 individuals (mean age 47.4 years, 43.4% males) was followed for nearly 10 years. Participants were also categorized into four groups according to presence/absence of CKD and MetS. Then, using a Multivariate Cox Regression, the Hazard Ratio (HR) of each group was estimated relative to individuals free of both CKD and MetS separately for obese (BMI&ge27.1 Kg/m2) and non-obese persons (BMI<27.1 Kg/m2).
Results: HR for non-obese patients with CKD but not MetS was obtained 2.06 (95%CI: 1.28-3.31) in men and 2.56 (1.04-6.31) in women. However, these associations were not significant for obese patients. Furthermore, among non-obese men and women with MetS alone, HR was estimated 2.52 (1.71-3.73) and 4.68 (2.20-9.95), respectively. For obese patients, these values were 1.70 (1.05-2.78) and 1.90 (1.16-3.13), respectively.
Conclusion: The results reflect that among those who had MetS alone, the risk of CHD incidence was twice higher in non-obese individuals compared to obese patients.
