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Showing 2 results for Post-Exposure Prophylaxis

Fatemeh Rostampour, Hamid Reza Khalkhali, Sima Masudi,
Volume 19, Issue 3 (12-2023)
Abstract

Background and Objectives: Animal bites are one of the most important public health problems that cause rabies. This study aimed to investigate the preventive measures taken for animal bite cases that occurred in West Azerbaijan province during 2012 to 2019.
Methods: This cross-sectional study involved the review data from all animal bite cases referred to rabies care centers in West Azerbaijan province. Information regarding prophylactic measures to prevent rabies, including post-bite procedures (washing, disinfection, dressing, stitches and receiving antibiotics), anti-rabies vaccine status (referral delay, vaccine dose received, vaccination history, anti-rabies serum, tetanus vaccination history) was analyzed using descriptive statistics. The relationship between delay in referral and the measures taken was investigated using the Chi-square test.
Results: Over the studied years, there were 47131 cases of animal bites. Among these, 63.9% were referred without delay, while 36.1% experienced a delay in referral. Notably, 99.6% of wounds were washed with soap and water, 94.5% were disinfected, and 31.3% received antibiotics. The proportion of individuals receiving antibiotics was significantly higher among those with delayed referrals. Regarding rabies vaccination, 77.3% had received all three initial doses, 15.4% had completed five doses, and 1.1% had not received any vaccine.
Conclusion: While prophylaxis measures for animal bite cases are commendable, there is a critical need for timely administration of rabies vaccine in rabies care centers. Implementing educational programs for general population to encourage prompt treatment-seeking in the event of animal bites is essential.

Aliasghar Fakhri-Demeshghieh, Hesameddin Akbarein, Rouzbeh Bashar, Mohammad Reza Shirzadi, Zahra Boluki, Narges Ghasemzadeh,
Volume 21, Issue 1 (6-2025)
Abstract

Background and Objectives: Rabies is a public health threat worldwide. This study aimed to determine the amount and trend of the costs of anti-rabies serum and rabies vaccine in Iran between 2015 and 2022.
Methods: Using national data from March 2015 to March 2022, the cost of anti-rabies serum, human rabies vaccine, and the total cost of both were determined. The annual trend of the serum, vaccine, and total cost was determined using Joinpoint regression with a maximum of one.
Results: The highest rabies serum and vaccine costs were observed in 2021 and 2020 (58.3 and 6.874 US million dollars), respectively. Average Annual Percent Change was statistically significant (p<0.001) and indicated an increasing trend in the costs of anti-rabies serum. The trend in vaccine costs between 2015 and 2020 was increasing, and the annual percent change between 2015 and 2020 (p˂0.001) and 2021 (p˂0.001) were statistically significant. The average annual percentage change was statistically significant for the total costs of anti-rabies serum and rabies vaccine (p˂0.001) and indicated an increasing trend in Iran.
Conclusion: The lowest rabies vaccine costs were observed in 2021, which might be due to the COVID-19 pandemic. To reduce rabies losses, the domestic production of anti-rabies serum, implementing rabies control measures in unowned dogs, and increasing public awareness about animal bites, particularly dog bites, are recommended.


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