Showing 7 results for Vaccine
M Karami, K Holakouie Naieni, A Rahimi, A Fotouhi, H Eftekhar Ardabili,
Volume 1, Issue 3 (2-2006)
Abstract
Background & Objectives: The DPT vaccine used in Iran is manufactured by the Razi Institute. So far, there have been no studies to determine the incidence and severity of adverse reactions to this vaccine. It was this lack of reliable information, plus concern for the unfavorable effects of such reactions on compliance with the vaccination schedule, that prompted the current study on DPT side effects.
Methods: In this cohort study, 1910 children aged 0 to 6 were divided into different groups (cohorts) on the basis of factors such as injection site and then monitored for the appearance of adverse effects. Data for this study were gathered through questionnaires filled by telephone or house-to-house interviews. We interviewed parents of children attending the 46 urban health clinics in Kermanshah. These interviews produced the data needed to fill the first part of the study questionnaire. The investigators then gave each parent an "information sheet" containing the data necessary for the second part of the questionnaire. The interviewee was asked to record on this sheet any adverse effects occurring over the following 48 hours. At the end of this period, the parent was contacted via telephone to fill the second part of the questionnaire. Data thus gathered were analyzed using the Statistical Package for Social Sciences (SPSS), version 11.5.
Results: In 1910 DTP immunizations given to children 0 to 6 years of age, followed for the development of adverse events occurring within 48 hours after immunization, the cumulative incidence rates were as follows: Swelling, 40.66% (38.43-42.89%) Redness, 43.08% (40.84-45.32%) Pain, 67.32% (65.20-69.40%) Fever (>38° C) 54.14% (51.89-56.40%) Fever (>40.5° C) 1.11% (0.64-1.59%) Drowsiness, 33.35% (31.21-35.48%) Persistent crying, 13.35% (11.81-14.88%) Local reactions, 75.79% (73.86-77.73%) and Systemic Reactions, 69.84% (67.76-71.97%). Only one child developed convulsion following immunization.
Conclusions: Varying reaction rates in different studies, such as high rate of pain and persistent crying in this study, may reflect the different preparations that were used or differenced in the methods for vaccine evaluation. Moreover, because of the severity of systemic reactions, DTP vaccine should be administered in the thigh region
A Fadaee, F Mosaddegh, M Alimoradi, Ma Pourhoseingholi,
Volume 2, Issue 3 (3-2006)
Abstract
Background & Objectives: There are near two million people from around the world have planning to journey for Hadje ceremony. Old age, Crowding dormitory, close contact, poor sanitation, poor health services, different community pattern, high temperature and other factors cause the infectious diseases particularly respiratory infection more than ever Influenza occur more common and cause more discomfort during this ceremony. This study in 1381 Clear the effect of influenza vaccine compare with placebo in this group of population Pilgrimage group.
Methods: This study had interventional randomize clinical design on 156 pilgrims in Abhar City. The pattern of the cases selection for reducing of bias effect was every other pilgrim for vaccine injection. All of the cases before, during and three week after return back from this ceremony had close health services. All the pilgrims had private document for recording the events.
Results: About 147 of pilgrims experienced had pulmonary infection (93% in case and 96% in control). There was no difference in either cases or control groups
Conclusions: There is no benefit for using influenza vaccine other than its indications in the patients but it needs additional studies.
M Karami, Sm Zahraei, Mm Gouya,
Volume 12, Issue 4 (2-2017)
Abstract
Background and Objectives: The Haemophilus influenzae (Hib) conjugate vaccine (HibCV) using a pentavalent formulation was introduced to the Iranian routine immunization program from November 2014. Iran is preparing to include Pneumococcal conjugate vaccines (PCV), as well. Measuring and monitoring the impact of HibCV and PCV are necessary to provide evidence for introduction and sustained administration of this vaccine.
Methods: We addressed the possibility of implementing the "3-tiered approach to IB VPD surveillance" as proposed by the World Health Organization using a feasibility study. Expert opinions were asked to address published literature regarding the study design and methods of measuring the impact of newly introduced vaccines.
Results: There are different methods and study designs to measure the impact of new vaccines, including population based active surveillance systems and vaccine effectiveness studies. The results of the feasibility study and expert opinions highlighted the superiority of a sentinel hospital-based surveillance system in Iran.
Conclusion: It is necessary to conduct some systematic reviews and meta-analyses to provide evidence for the trend of Hib and Streptococcus pneumonia related diseases, i.e. invasive bacterial diseases including meningitis, pneumonia, and sepsis. To monitor indirect effects of the PCV vaccine, implementing periodic surveys on the prevalence of nasopharyngeal carriers are recommended.
Z Baradaran Seyed , L Pishraft Sabet , Mh Fallah Mehrabadi ,
Volume 15, Issue 1 (5-2019)
Abstract
Background and Objectives: Highly pathogenic avian influenza (HPAI) viruses are particularly important due to huge economic consequences and public health concerns. During recent years, because of the severity of epidemics and failure in the control and eradication of HPAI, vaccination has been introduced into the National Prevention and Control Program of some countries, including Iran. This article discusses the role of vaccination in the control of HPAI, the characteristics and constraints of the vaccine, types of commercial vaccines, and previous experiences.
Methods: Scientific databases were searched to collect essential evidence on the role of vaccination in controlling HPAI in a variety of poultry and birds with no time and language restrictions. The articles related to the efficacy and effectiveness of the commercial vaccines on at a national level or population-based studies in some farms were included in present study.
Results: Because of the high pathogenicity and variability of the influenza virus as well as the shortcomings of some commercial vaccines in prevention of virus transmission, vaccination should only be taken into consideration when all other methods of disease control are ineffective. The consequences of the use of vaccines containing the seeds non-antigenically matched with the circulating strains have been reported frequently.
Conclusion: In the national vaccination program, informed policymaking requires evidence based vaccinology that can facilitate development of the national infrastructure with awareness of the limitations of commercial vaccines and the realistic expectations of logistic, financial, and human resources.
S Rahmani, M Karami, , M Adabi, A Doosti Irani,
Volume 16, Issue 1 (6-2020)
Abstract
Background and Objectives: After the introduction of the pneumococcal vaccine, an increase has been observed in the disease due to nonspecific stereotypes of the vaccine. This study was conducted to determine the spatial distribution of pneumococcal vaccine coverage and common stereotypes of streptococcus pneumonia after vaccine introduction in the vaccine recipient countries.
Methods: The Web of Sciences, Medline, and Scopus were searched using a designed search strategy. Studies that reported the prevalence of the stereotypes of streptococcus pneumonia and replacement of the stereotypes were included. In addition, the coverage of pneumococcal vaccination in the countries was extracted from the reports of the World Health Organization. The spatial distribution of vaccine recipient countries and vaccination coverage were determined using the ArcGIS 10.6.1.
Results: Of 6989 retrieved references, 325 studies were included. The highest proportion of vaccine recipient countries were in the African, European and Western Pacific regions. The vaccination coverage increased up to 2017 in the vaccine recipient countries. The common specific vaccine serotypes after the introduction of vaccine were 19A, 5, 3, 14, 19F, 7F, 23F, 6B. In addition, common nonspecific vaccine serotypes were 11A, 15A/B, 8, and 12F.
Conclusion: The results indicated pneumococcal vaccination is not included in the immunization program in many countries. In addition, common serotypes after vaccine introduction of include 19A, 5, 3, 14, 19F, 7F, 23F, 6B. Therefore, it is recommended the health policymakers have a plan for pneumococcal vaccine introduction based on the pattern of the commonly detected stereotypes.
Y Salimi, T Paykani, S Ahmadi, M Shirazikhah, A Almasi, A Biglarian, N Rajabi Gilan, Z Jorjoran Shushtari ,
Volume 16, Issue 5 (3-2021)
Abstract
Background and Objectives: Vaccine acceptance could seriously affect global efforts to control the Covid-19 pandemic. The aim of this study was to estimate the Covid-19 vaccine acceptance and its related factors in Tehran and Kermanshah.
Methods: A population-based cross-sectional study was conducted on 850 participants in Tehran and Kermanshah using the random digit dialing method. Multiple logistic regression was used to estimate the adjusted odds ratio of factors related to vaccine acceptance.
Results: The frequency of the Covid-19 vaccine acceptance was 66.47% (95% confidence interval: 69.57%, 63.21%). Moreover, 86.02% of the participants stated that they would use any type of (Iranian / foreign) vaccine approved by the Iranian Ministry of Health. However, 13.98% of the participants stated that they only preferred foreign approved vaccines (if available). The variables of age, fatalism, and socioeconomic status had significant associations with the Covid-19 vaccine acceptance.
Conclusion: Based on the results of this study, the Covid-19 vaccine acceptance was moderate. In order to achieve herd immunity by vaccination faster in our society, the strategy of prioritizing vaccination can be planned based on the related variables such as religious beliefs and fatalism, younger age groups, and people with higher socio-economic status that are willing to receive the vaccine.
Fariba Zomorrodi Zare, Fatemeh Khosravi Shadmani, Roya Safari Faramani, Fatemeh Torkamanasadi, Yazdan Rezaei, Farid Najafi,
Volume 20, Issue 1 (6-2024)
Abstract
Background and Objectives: During the COVID-19 pandemic, vaccination was crucial in preventing the spread of SARS-CoV-2 and saving numerous lives. Countries implementing COVID-19 vaccination programs have reported significant reductions in cases, ICU admissions, and COVID-19-related deaths. This study aimed to evaluate the effectiveness of vaccines used in Hamadan province, explicitly focusing on their impact on hospitalization and death caused by COVID-19.
Methods: A test-negative case-control design (TND) was conducted involving patients aged 12 and above who were admitted to hospitals in Hamadan province, Iran, and had symptoms of acute respiratory diseases. Data were extracted from hospital and health system databases. Multiple logistic regression analysis was performed to estimate vaccine effectiveness for the first, second, and reminder doses in prevention of hospitalization, and severe outcomes (ICU admission or death).
Results: The study was conducted on 3,702 patients, and the maximum effectiveness of vaccines against hospitalization was 50% for patients who received a booster dose. The effectiveness of the first dose of vaccine on severe outcomes (admission to ICU or death) was estimated as 42%, but the effectiveness of the vaccines in the second and booster doses were not significant.
Conclusion: Despite the predominant use of inactivated virus vaccines and delayed initiation of vaccination in Iran, this study shows the effect of vaccination on reducing hospitalization and improving the outcomes of COVID-19. The use of more effective vaccines at a more appropriate time plays an important role in reducing the burden on health services and preventing further transmission in future epidemics.
