Mechanisms of developement and metastasis of malignant melanoma

Sadeghi Urmia, Ali; Barati, Babak; Taghinejad, Javid

Volume 9, Issue 2 (2018, Volume 9, Number 2 2018) jdc 2018, 9(2): 120-134 | Back to browse issues page

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Sadeghi Urmia A, Barati B, Taghinejad J. Mechanisms of developement and metastasis of malignant melanoma . jdc 2018; 9 (2) :120-134
URL: http://jdc.tums.ac.ir/article-1-5321-en.html

Mechanisms of developement and metastasis of malignant melanoma

Ali Sadeghi Urmia¹

, Babak Barati²

, Javid Taghinejad ^*

1- Food and Drug Central Laboratory, Urmia, Iran
2- Biological Sciences and Technology Center, Faculty of Basic Sciences, Imam Hossein University, Tehran, Iran
3- Department of Microbiology, Malekan Branch, Islamic Azad University, Malekan, Iran , J_taghinejad@yahoo.com

Abstract: (10881 Views)

Cancer is a genetic condition. Some cancers are inherited, but most are caused by mutations in somatic cells. The cause of these mutations is inherent error in the transcription of DNA or exposure to carcinogens. Malignant melanoma is the most serious type of skin cancer which develops from pigment-containing cells known as melanocytes. The most potent risk factors for melanoma is the presence of multiple benign moles or abnormal spots, and family history of melanoma. Metastasis is a complex multi-stage process that results in development of secondary malignant growths and the spread of cancer cells to other areas of the body leading to patient’s death. Melanoma metastases are mainly to the lymph nodes, liver, lungs, and central nervous system. The aim of this article is to review the mechanisms of development and metastasis of melanoma by searching database such as SID, Google Scholar, American Electronic Library,Springer and PubMed.

Keywords: melanoma, metastasis, genetics, cancer

Full-Text [PDF 264 kb] (1839 Downloads)

Type of Study: Review | Subject: Special
Received: 2018/09/11 | Accepted: 2018/09/11 | Published: 2018/09/11