Volume 10, Issue 2 (2019, Volume 10, Number 2 2019)
jdc 2019, 10(2): 61-68 |
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Shojaedin Givi B, Khamesipour A, Naderimanesh H. Fabrication of polymeric microneedle arrays containing Amphotericin-B for transdermal drug delivery. jdc 2019; 10 (2) :61-68
URL: http://jdc.tums.ac.ir/article-1-5389-en.html
URL: http://jdc.tums.ac.ir/article-1-5389-en.html
1- Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran ,naderman@modares.ac.ir
2- Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran ,
Abstract: (3059 Views)
Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a model in skin infections.
Methods: In this study, microneedles were fabricated by three-step molding method, which included master mold making, polymeric matrix that blending of polyvinyl pyrrolidine and methacrylic acid and finally casting.
Results: The identification of Amphotericin-B in polymeric microscopic compositions was investigated by absorption and emission spectroscopy. Also, the mechanical strength of microneedles, which confirms their ability to penetrate the skin, was investigated by a transducer.
Conclusion: In this study, the design and fabrication of a skin-permeable polymeric microneedle array with biodegradability and biocompatibility characteristics in physiological environment was performed. Using the properties of designed needles, loading of Amphotericin-B was used for the treatment of leishmaniasis and skin fungal infections.
Methods: In this study, microneedles were fabricated by three-step molding method, which included master mold making, polymeric matrix that blending of polyvinyl pyrrolidine and methacrylic acid and finally casting.
Results: The identification of Amphotericin-B in polymeric microscopic compositions was investigated by absorption and emission spectroscopy. Also, the mechanical strength of microneedles, which confirms their ability to penetrate the skin, was investigated by a transducer.
Conclusion: In this study, the design and fabrication of a skin-permeable polymeric microneedle array with biodegradability and biocompatibility characteristics in physiological environment was performed. Using the properties of designed needles, loading of Amphotericin-B was used for the treatment of leishmaniasis and skin fungal infections.
Type of Study: Research |
Subject:
Special
Received: 2019/09/24 | Accepted: 2019/09/24 | Published: 2019/09/24
Received: 2019/09/24 | Accepted: 2019/09/24 | Published: 2019/09/24
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