Volume 14, Issue 4 (Volume 14, No 4 2024)
jdc 2024, 14(4): 231-242 |
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Tamimi P, Tamimi P, Ghaderi A. The role of incRNAs in pathogenesis, prognosis and treatment of non-melanoma skin cancer. jdc 2024; 14 (4) :231-242
URL: http://jdc.tums.ac.ir/article-1-5693-en.html
URL: http://jdc.tums.ac.ir/article-1-5693-en.html
1- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Pegahtamimi.md@gmail.com
2- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (488 Views)
Dysregulation of long non-coding RNA may lead to various diseases including cancer. Recently, many lincRNAs have been discovered for their important roles in melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). These long non-coding RNAs are involved in skin cancer cell proliferation, angiogenesis, invasion, and metastasis.
Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.
Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.
Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.
Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.
Type of Study: Review |
Subject:
General
Received: 2024/03/18 | Accepted: 2024/02/4 | Published: 2024/02/4
Received: 2024/03/18 | Accepted: 2024/02/4 | Published: 2024/02/4
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