Journal of

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Background and Aim: Dandruff and seborrheic dermatitis (SD) are common chronic skin diseases. There are many chemical drugs for treating dandruff and SD. Prolonged use of them may cause side effects and drug resistance. The aim of this study was to compare the efficacy of a herbal extract lotion with clotrimazole 1% lotion in the treatment of SD.

Methods: Twenty volunteers (12 men and 8 women) aged 20 to 40 years, with seborrheic dermatitis were enrolled in this trial and were randomly allocated into two groups. One group was treated with a herbal extract lotion and the other group with clotrimazole lotion. The herbal extract contained common sage, thyme vulgaris, tea tree oil, lavender, willow, rosemary, and aloe vera. The patients were instructed to use the lotions three times a week for 4 weeks. We evaluated the patients by clinical assessment and measured the scalp sebum, pH, and dandruff number before two weeks, and four weeks after completed a treatment. At the end of the study, each participant satisfaction form.

Results: At the end of the study, the participants whom received the herbal extract lotion had a significantly greater reduction in scalp scaling, erythema, itching, and number of dandruff compared with those who received clotrimazole (P<0.05). The patient satisfaction score was also higher in the herbal extract group (60% versus 10%).

Conclusion: This study showed that herbal extracts lotion was effective in the treatment of dandruff and seborrheic dermatitiand can be an appropriate alternative to chemical agents.

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A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.

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Wounds are any type of tissue dehiscence which can occur on skin, mucosae or connective tissue. After the wound has created, inflammatory process, the immune system changes as well as the skin repair cascade will be activated. To provide a product that can direct the above processes in a desirable repair mechanism will be useful. Studies have shown that aloe vera products, with effects such as increased collagen production, antioxidant and water retaining properties, are good options.
Aloe vera grows mainly in arid regions and this fact can be welcomed in many parts of the world. The use of medicinal herbs also reduces the cost for the health systems. Aloe vera is a plant that does not require much cost for plant and harvest. Besides, the compatibility of aloe vera products with a variety of formulations encourages formulators to use it in the pharmaceutical and cosmetic industries.
In this review, the use of aloe vera in wound management and some skin diseases will be discussed.

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Background and aim: Human dermal fibroblasts (HDFs) are key regulators of skin homeostasis through extracellular matrix remodeling. Polydeoxyribonucleotides (PDRN) and magnesium ascorbyl phosphate (MAP) are recognized as skin regenerative agents, but their molecular effects on HDFs are not fully elucidated. This study aimed to investigate the effects of PDRN and MAP on cellular proliferation and type I collagen gene expression in HDFs.
 

Methods: The HDF cell line was treated with PDRN and MAP, and cell viability was evaluated using the MTT assay at 24, 48, and 72 hours. Based on viability outcomes, optimal concentrations of PDRN (100 ng/ml) and MAP (250 µg/ml) were selected. Seventy-two hours post-treatment, the expression levels of KI-67 and COL1A1 genes were analyzed via qPCR (P<0.05).
 

Results: Cell viability analyses demonstrated significant time- and dose-dependent responses for both PDRN and MAP. At the molecular level, independent treatments with PDRN and MAP upregulated KI-67 gene expression, confirming an enhanced cellular proliferative capacity. Conversely, in a divergent manner, COL1A1 gene expression was downregulated under these exact treatment conditions.
 

Conclusion: PDRN and MAP induce a divergent response in HDFs; while promoting mitogenic activity, they simultaneously suppress fibrogenesis and COL1A1 expression. This cellular reprogramming underscores the therapeutic potential of these compounds in anti-fibrotic strategies and scarless wound healing. However, in vivo studies are required to conclusively validate these findings.