Journal of

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Background and Aim: Tumor angiogenesis is essential for tumor growth and appears to play an importating role both in invasive growth and metastasis. Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. Basal cell carcinoma generally shows a relatively benign course in contrast to squamous cell carcinoma .This study investigates whether the behavior of these tumors could be explained by differences in their angiogenesis pattern.
Methods: Vessel counts were made of blood vessels in stroma and the body of 50 variants of BCC of skin samples including: nodular, micronodular, sclerosing and superficial, both after H&E and immunohistochemical staining for CD31 and CD34 markers.
Results: The body vessel counts of invasive variants (sclerosing & micronodular) differed significantly from the counts of noninvasive variants (nodular and superficial) using both CD31 & CD34 markers. The stromal vessel counts compared between invasive and noninvasive variants showed no significantly difference using CD31 & CD34 markers, respectively.
Conclusion: The invasive growth pattern of BCC variants correlated with the microvascular density and according to results, vessel counts of the body play a more important role.

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Burn is one of the most severe traumas experienced in humans with severe pain. Some researches indicate the positive impact of spiritual-religious interventions on different aspects of burn injuries. Therefore, the purpose of the present study was to investigate articles published in domestic and foreign databases on the effect of spirituality and religion on burn patients in Iran. The present study is a review study, all Persian articles in scientific journals that are in internal databases including Database SID, Iranmedex, Magiran, Irandoc and external databases such as Google Scholar, pubmed and indexed in persian were reviewed for the purpose of the study. Out of the reviewed articles, 4 articles were finally identified and evaluated according to the purpose of the study. Studies that did not have the full text were excluded, as well as articles that examined only the prevalence of burns and studies that did not specify how interventions were performed. Findings indicate the positive effect of spiritual-religious interventions on increasing the ability to cope with burn pain. Therefore, it is suggested that spiritual-religious interventions in nursing care be more widely considered.

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Background and Aim: Importance of hand hygiene with the COVID-19 has been raised around the world from 2019. We aimed to determine the effect of hand skin health in menopausal women during the covid-19 pandemic.
 

Methods: It was a cross-sectional study which has conducted on 94 subjects those were referred to menopause clinic in Imam Khomeini Hospital in Ahvaz city during September to November 1999. The tools of this study were the Personal Characteristics Questionnaire and Hand and skin self-assessment tool (Appendix 3 of “WHO GUIDELINES ON HAND HYGIENE IN HEALTH CARE “). Data has entered and analyzed by using software SPSS version 22. The level of significance was considered as less than 0.05.
 

Results: The mean age of women participating in the study was 53.6. The average frequency of hand washing outdoors was 5.28 and 10.43 indoors. Most women (94.7%) had reported at least some degree of skin problem and reported that their hand skin problems increased significantly during the COVID-19 pandemic.
 

Conclusion: Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.

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Impaired wound healing following significant tissue damage such as severe burns, trauma, or surgery can result in scarring and skin fibrosis. Pathological scarring leads to changes in the natural shape of the wound and, in addition to cosmetic problems, may be accompanied by pain and even limit the person's normal movement. The immune response plays a very important role in the wound healing process. Activation of immune cells and factors initiates the inflammatory process, facilitates wound cleansing, and tissue repair and regeneration. However, disruption of the immune system during the wound healing process leads to persistent inflammation and delayed healing, ultimately leading to the development of chronic wounds. The microenvironment of a chronic wound contains a large number of immune cells, including proinflammatory macrophages, and high expression of inflammatory mediators such as TNF-α and IL-1β is observed in it. Among them, macrophages, as innate immune cells, play a key role in promoting the immune response and activating adaptive immunity. These cells are also key factors in the transition from the inflammatory phase to the tissue repair phase. As a result, dysregulation of macrophage function will have consequences such as scarring. Therefore, knowledge of the exact mechanism of the inflammatory process during wound healing, the inflammatory and anti-inflammatory mediators produced, and the effect of macrophages on this process can promise the achievement of new strategies in scarless wound healing. Therefore, this article discusses the mechanism of the immune system during the inflammatory process, and the key role of macrophages in this process, as well as scar formation.