Journal of

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Background and Aim: Acne is one of the most common diseases among young individuals. Controversial findings are reported about the effect of glycemic index (GI) and glycemic load (GL) of the diet on acne vulgaris. The aim of this study was to investigate the effect of GI and GL of diet on severity of acne.

Methods: All relevant studies on effects of GI or GL on acne published up to December 2016 were collected using PubMed, Google Scholar, Science direct, Ovid and Cochrane library.

Results: Of 714 articles in our initial research, 6 interventional and 3 case-control studies were included.
Case-control studies revealed that patients with acne vulgaris consumed diets with a higher GI rather than control group. Intervention with a low GI diet reduced lesion counts and improved the severity of acne as well as insulin sensitivity compared with those under high GI diet.

Conclusion: Overall, a diet with low GI and GL could improve acne severity and inflammatory lesions.

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Background and Aim: Curcumin possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. The aim of this study was to develop liposomal formulation of curcumin and evaluate the leishmanial effects of its topical use against L. major in vitro and in vivo.

Methods: Nanoliposomes containing 1, 2 or 3% curumin were prepared by fusion method and characterized for their size, morphology and stability. The in vitro efficacy of liposomal form of Curcumin against promastigotes and amastigotes form of L. major was also evaluated. Moreover, the leishmanial effect of formulations was evaluated in infected BALB/c mice. The lesions were treated topically by different formulations twice a day, for 4 weeks. During this time and 4 weeks after treatment, lesions size was measured every week. The level of splenic parasite burdens was investigated in week 4 after parasite inoculation.

Results: Curcumin showed no leishmanicidal effect against live promasigotes and amastigotes in culture media. There was no significant difference between treated and control animals regarding lesion size and splenic parasite burden.

Conclusion: The results of this study showed that nanoliposomes containing curcumin in topical form has no significant leishmanicidal effect in vitro and in vivo against
L. major.

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A wound is described as any laceration in normal anatomic structure and functional integrity of the skin. Chronic wounds don’t progress through the normal wound healing process in 3 months leaving open laceration of different degrees of severity. Diabetic wound healing is an insurmountable process due to the chronic nature of diabetic wounds. For these complications, this has been a challenge in the health care system. By the appearance of regenerative medicine, advisedly stem cell-based therapies and ingredients have been gained the focus of researchers and professionals as well. As there is no definite cure for diabetic wounds and forasmuch as the appearance of regenerative medicine and cell-based therapies there is a big hope to find a definite treatment for diabetic wounds. In this article novel therapies based on stem cells were observed.