Zohreh Bakhtiyari, Msc, Mohammadreza Radan, Md,
Volume 4, Issue 2 (6-2013)
Abstract
Skin is one of the most sensitive parts of the body and is important to maintain the beauty of man. Herbal products have fewer side effects than chemicals and have pharmacological effects on the skin, so are used in cosmetic preparations.
Books, articles and electronic databases including ISI Web of Science, PubMed, Magiran and IranMedex were searched to identify plants with positive effects on the skin, regardless of adverse effects and their interactions.
A number of plants which were used in the treatment of skin diseases and their effects had been established, were chosen and reviewed. Avocado, thyme, aloe vera, chamomile, almond, licorice, calendula, olive and yarrow were included in this review.
There are many herbs that have a role in the prevention and treatment of skin diseases, and are used in either traditional medicine or the preparation of cosmetics. The effects of a number of them have been scientifically proved and this information for the production of cosmetic and pharmaceutical products can be used.
Hanie Bakhtiyari, Mohamadsaeid Emaminia, Amin Bakhtiyari,
Volume 16, Issue 3 (Volume 16, No 3 2025)
Abstract
Skin aging is a complex process characterized by structural alterations, reduced elasticity, and wrinkle formation, adversely affecting self-confidence and quality of life. Emerging evidence indicates that epigenetic mechanisms—including DNA methylation, histone modifications, and microRNA regulation-play pivotal roles in initiating and progressing these changes. These modifications, which occur without altering the DNA sequence, are reversible and thus represent promising targets for rejuvenation interventions. This review provides a comprehensive analysis of the role of these pathways in skin aging, as well as the impact of environmental factors such as ultraviolet (UV) radiation, air pollution, and nutrition. Furthermore, it discusses innovative therapeutic strategies, including Sirtuin activators, histone modification inhibitors, platelet-rich plasma (PRP), cell-based therapies, and epigenetic editing technologies. Although preliminary results are encouraging, limitations such as the paucity of longitudinal studies, methodological heterogeneity, and safety and ethical concerns remain. Overall, a deeper understanding of epigenetics may open new avenues for personalized and non-invasive skin rejuvenation therapies.
