Showing 7 results for Farshchian
Akram Ansar, Mahmoud Farshchian, Seyed Mostafa Ghasemzadeh,
Volume 2, Issue 2 (6-2011)
Abstract
Background and Aim: Lichen planus (LP) is a cutaneous disease characterized by violaceus flat topped papules in variable size. It may involve body surface areas such as mocus membranes. Some studies have reported an association between oral LP ad diabetes mellitus. The aim of this study was to compare the frequency of diabetes mellitus between patients with and individuals without LP.
Methods: A case-control study was done on 30 patients suffering oral LP as case group and 60 healthy individuals as control group. Diagnosis of oral LP was confirmed by typical clinical and histopathologic findings. Participants in control group were selected from general population after matching for sex and age. Venipuncture was done to take 5 ml blood sample for measuring fasting serum blood glucose levels in both groups. A repeated blood sampling was done for ones with abnormal results in the first sampling. Findings of the study were analyzed using SPSS 16.0 statistical software.
Results: Thirty LP patients [man 13 (43.3%), woman 17 (56.7%)] with mean age (mean±stabdard deviation) of 46±13.7 years and 60 healthy individuals [man 26(43.3%), woman 34 (56.7%)] with mean ages of 46±14 years were recruited to this study. In case group only one person (3.3%) suffered from diabetes mellitus, but none of healthy group had fasting blood sugar above the normal value. In quantative evaluation, mean level of fasting blood sufar was 102.5±33 mg/dL in case group and 111.1±49.3 mg/dLin control group (P=0.09).
Mahmoud Farshchian, Ghasem Rahmatpour Rokni, Mahnaz Sharifian,
Volume 2, Issue 4 (12-2011)
Abstract
Background and Aim: Adverse drug reactions are inevitable outcomes of drug therapy, which may cause mortality and morbidity for those whom are treated in this way. Cutanous adverse drug reactions are abserved in 2% to 3% of inpatients but only 2% of them are considered serious and may cause death. The aim of this study was to determine the cause and clinical forms of adverse drug reactions referred to department of dermatology.
Methods: This cross-sectional study that was done on patients with diagnosis of cutanous adverse drug reactions in 2007 and 2009. All patients suspected with diagnosis of adverse drug reactions were examined by an experienced dermatologist for determination of different kinds of clinical manifestations.
Results: During the study period, 308 patients were recruited. Cutanous adverse drug reactions were found to be more frequent in females (63%) than in males (37%). Betalactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most frequent observed drug reaction (59.2%) followed by fixed drug eruption (18.5%) and maculopapular rashes (14.9%).
Conclusion: In this study adverse cutaneous drug reactions was mainly induced by betalactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be: acute urticaria, fixed drug eruption and maculopapular rashes.
Akram Ansar, Vali-O-Allah Hosseinpoor, Abbas Zamanian, Mahmood Farshchian,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: C-reactive protein (CRP) is an inflammatory biomarker and its level increases in serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index (PASI) score.Methods: CRP serum levels in patients with psoriasis were measured before and after treatment with narrow-band ultraviolet B (NB-UVB) and the data were analyzed in relation the PASI score improvement.
Results: Baseline CRP levels among psoriatic patients were higher than normal. These levels decreased significantly after treatment. At the beginning of the study, patients with higher levels of CRP also had more extensive and severe skin involvement. Highest decrease in CRP was observed in patients who responded better to the treatment and acheived higher PASI 75%. There was an association between baseline PASI scores and CRP levels.
Conclusion: Patients with moderate to severe plaque-type psoriasis had systemic inflammation too, which was demonstrated by having higher levels of CRP. Skin disease activity also was associated with higher levels of CRP. Phototherapy healed the psoriatic skin lesions and also reduced inflammation and decreased CRP levels.
Mahmood Farshchian, Akram Ansar, Saadat Torabian, Seyed Mostafa Ghasemzadeh,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: In addition to the age and immune suppression, several risk factors for herpes zoster have been studied. The aim of this study was to evaluate the family history of herpes zoster as a risk factor for this disease.Methods: This case-control study was conducted at Farshchian hospital, Hamedan, Iran. The cases were patients with confirmed diagnosis of herpes zoster. The controls were chosen from individuals with minor or chronic dermatologic diseases or their companions, who had no history of herpes zoster. Immune deficiency was the main exclusion criteria. Information was asked using special questionnaires administered by blinded investigators. Data were analyzed using chi squared test. Odds ratios (OR) with 95% confidence interval (95% CI) were calculated to compare proportions in two groups.
Results: Case and control groups included 217 and 200 participants, respectively. The mean ± standard deviation of ages in case and control groups were 49.08±15.59 and 49.96±15.54 years, respectively (P=0.936). 53.5% of cases and 54.5% of controls were women (P=0.845). The frequency of herpes zoster in first-degree relatives in cases and controls was 65/217 (30%) and 16/200 (8%) respectively (OR [95%CI] = 4.91 [2.73-8.85]). Positive history for second degree relatives was 36 (16.6%) and 8 (4%) in cases and controls, respectively (OR [95%CI] = 4.77 [2.16-10.54]). This proportion for at least one relatives was 101 (46.6%) and 24 (12%) in cases and controls, respectively (OR [95%CI] = 6.26 [3.79-10.36]).
Conclusion: This study suggests that positive family history is a risk factor for herpes zoster.
Mahmood Farshchian, Elaheh Soltanie, Leila Moosavee, Hossein Mahjoob, Abbas Zamanian, Haleh Nazerian, ,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Psoriasis is a chronic inflammatory
dermatosis that affects 0.6% to 4.8% of the general population. Our aim was to compare the effect of narrow band UVB
(NB-UVB) on normal flora of cutaneous plaques and normal skin in psoriatic
patients.
Methods: Twenty
psoriatic patients without any contraindication of phototherapy were enrolled
in this study. Samples from psoriatic lesions and adjacent normal skin, before
and after phototherapy with NB-UVB were taken. Patients were treated with
NB-UVB three times weekly until complete remission. Finally, quantity of normal
cutaneous flora on normal and involved skin, before and after treatment was compared.
Results: The mean±SD of
the NB-UVB sessions and the mean cumulative dose were 26.35±4.95 and 2.05±0.57 J/cm2, respectively. The number of Staphylococcus epidermidis, S. aureus and diphtheroids on psoriatic plaques reduced after phototherapy.
Conclusuion:
The quantity of normal cutaneous flora on normal skin is less than psoriatic plaques,
and it reduced on normal and involved skin after phototherapy.
Mahmoud Farshchian, Akram Ansar, Mohammad Reza Sobhan, Saadat Torabian,
Volume 4, Issue 1 (3-2013)
Abstract
Background and Aim: Psoriasis is a common chronic inflammatory skin disease. The risk factors of metabolic syndrome have been reported with greater frequency in patients with psoriasis. In this study, we aimed to evaluate these risk factors and compare them with normal population, as the control group.
Methods: In this case-control study, 55 patients with psoriasis were studied from 2011 to 2012 and 55 matched (for sex and age) persons were considered as control group. Age, gender, body mass index, systolic and diastolic blood pressures, smoking, alcohol consumption, type of disease, and blood levels of triglyceride, total cholesterol, LDL, HDL, and fasting sugar were evaluated in both case and control groups and compared.
Results: Our findings showed that levels of TG (P=0.005,OR: 1.02, 95%CI: 1.0-1.34) and LDL (P=0.03, OR: 1.04, 95%CI: 1.0-1.09), the frequency of smoking (P=0.02, OR: 2.2, 95%CI: 1.1-3.2), and the mean of systolic blood pressure (P=0.004, OR: 1.07, 95%CI: 1.02-1.33) were significantly higher in psoriatic patients, compare with control group.
Conclusion: Higher frequency of hypertension and lipid abnormalities in psoriatic patients may enhance the risk of cardiovascular diseases in them. Therefore, we recommend to check all patients with psoriasis, regardless of their disease severity, for serum lipid profiles and blood pressure. In addition, we strongly recommend giving up smoking, as a part of psoriasis treatment.
Hamidreza Ghasemi Basir, Mahmood Farshchian, Pedram Alirezaei, Mahdis Jahani,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
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Background and Aim: Cicatricial
alopecia is the result of irreversible substitution of hair follicles with
fibrotic tissue and presents as permanent loss of hair. Only a few studies
have investigated the clinical and histopathological characteristics of
cicatricial alopecia in Iran. The aim of this study was to determine the
demographic, clinical and histopathological characteristics of patients with
cicatricial alopecia who referred to our dermatology outpatient clinic in
Farshchian hospital in a two year period, and to evaluate the diagnostic
value of histopathologic criteria in diagnosing different kinds of
cicatricial alopecias.
Methods: This was a
cross-sectional study. Eighty nine patients who underwent skin biopsy due to
clinical diagnosis of cicatricial alopecia were included. Demographic and
clinical characteristics of patients as well as clinical diagnosis were
recorded and the biopsy samples were evaluated by two different pathologists
who were unaware of each other's diagnosis. Histopathological diagnosis of
patients according to each pathologist's opinion was recorded separately and
statistical analysis was performed to obtain the coincidence coefficient between
two pathological diagnosis.
Results: The most common
forms of cicatricial alopecias due to clinical and histopathological
diagnosis were: lichen planopilaris, disciod
lupus erythematosus, alopecia
areata, pseudopelade
of Brocq, folliculitis
decalvans and
central centrifugal cicatricial alopecia. Moreover,
our findings showed a powerful coincidence coefficient between clinical
diagnosis and the first pathologist diagnosis (kappa=0.836), an average to
powerful coincidence coefficient between the second pathologist diagnosis and
clinical diagnosis
(kappa=0.703) and finally an average to powerful coincidence coefficient
between the two pathologists diagnosis
(kappa=0.663).
Conclusion: Diagnosis of
cicatricial alopecia depends upon clinical and also histopathological
examination. Diagnostic value of histopathological criteria even at the end
of scarring process when there is considerable overlap between microscopic
findings of different etiologies of cicatricial alopecias is still acceptable
and there is no need to re-evaluate the biopsy specimen by a second
pathologist in order to confirm the diagnosis.
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