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Showing 4 results for Farzaneh
Onychomycosis in patients with underlying diseases referred to Razi Hospital in Tehran in 2010-11
Mehraban Falahati, Zeinab Ghasemi, Shirin Farehyar, Ebrahim Eskandari, Mahtab Ashrafi, Farzaneh Ahmadi, Gholamhossein Ghaffarpour,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Onychomycosis is the fungal infection of nails. Patient’s immune system has an important role in initiation of onychomycosis. One of the causes of the increased prevalence of onychomycosis is the increasing number of patients with local or general immune system disorders. In hormonal disorders such as diabetes mellitus, Cushing's syndrome and hypothyroidism superficial vascular disorders and individuals with immune deficiency, onychomycosis prevalent. The aim of this study was to investigate onychomycosis in individuals with underlying diseases who referred to Razi hospital in Tehran.
Methods: In this cross-sectional study, nail specimens of 250 patients who have nail dystrophy with an underlying disease whom were referred to mycological laboratory of Razi hospital in 2010-11 were evaluated with direct microscopy and culture on Sabouraud dextrose agar and Sabouraud dextrose agar containing chloramphenicol and cyclohexamide. For differential diagnosis of fungi, complementary tests were used.
Results: Eighty-nine (35.6%) of 250 individuals with underlying diseases and nail dystrophy, were affected with onychomycosis. Among these pateints, 52 (58.4%) cases had yeast infection, 19 (21.3%) had dermatophyte infection, and 18 (20.2%) had saprophyte infection. Diabetes mellitus (37.1%), cardiovascular diseases (14.7%), pemphigus (9%), psoriasis (7.9%), hypothyroidism (6.7%) and chronic eczema (5.6%) were the most common underlying diseases observed in patients with onychomycosis.
Conclusion: Onychomycosis is common in hormonal disorders like diabetes mellitus and hypo-thyroidism superficial vascular disorders and individual who suffer immunodeficiency.

Effect of different preservatives during freezing process on infectivity of Leishmania major in mice model
Farzaneh Zarrinkar, Ali Khamesipour, Akram Miraminmohammadi, Ebrahim Eskandari, Mahmoud Nateghi Rostami, Esmaeil Fallah,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Leishmanization (LZ) is an effective tool to prevent cutaneous leishmaniasis. Standardization of Leishmania is the main drawback of LZ. The aim of this study was to assess the effect of various preservatives on the infectivity of Leishmania.
Methods: L.major harvested at different stages of growth logarithmic, early and late stationary phases were frozen using various preservatives of saccharose, glycerol, trehalose, glucose, sorbitol, and dimethyl sulfoxide (DMSO). The harvested parasites were inoculated into BALB/c mice before and after freezing. The infectivity of the parasites was checked. IFA test was used to assess the rate of metacyclic parasite.
Results: The ratio of live Leishmania in different growth stages and various preservatives were 89.0% to 98.2%. The lesion development in groups of mice which received Leishmania in sacarose + glycerol or DMSO was started from 3rd week and at 5th week all the mice showed lesion. The group of mice which were inoculated with early or late stationary phases in saccharose + glucose, saccharose + glycerol, glycerol 15% or DMSO showed lesion from 4th to 5th week and in 100% showed lesions at 8th week. The rate of metacyclic parasites increases from log phase to early and late stationary phases.
Conclusion: There was a correlation between percent of live parasite and the rate of lesion development in BALB/c mice. Saccharose 22.5% + Glyserol 22.5% were the most appropriate preservative to freeze L. major. IFA test is used to detect metacyclic Leishmania. A correlation was seen between the rate of lesion development in BALB/c mice and IFA positivity.

Causative agents of tinea unguium in Razi Hospital, Tehran, Iran in 2010 and 2011
Zeinab Ghasemi, Mehraban Falahati, Farideh Zaini, Gholam Hossein Ghaffarpour, Farzaneh Ahmadi, Seyed Ebrahim Eskandari,
Volume 6, Issue 2 (Volume 6, Number 2 2015)
Abstract
Background and Aim: Tinea unguium is a common disease with worldwide distribution most commonly seen in adult patients. Trichophyton rubrum and T. interdigital are the most common causes. The aim of this study was to investigate the frequency of tinea unguium causative agents in a referral dermatology hospital in Tehran, Iran. Methods: This cross sectional study was conducted in 2010 and 2011 on clinically suspicious patients for tinea unguium referred to the Mycology Laboratory, Razi Hospital, Tehran, Iran. Samples from 700 patients were examined using direct smear microscopy and culture. Direct microscopic examination of the specimens was carried out using 20% potassium hydroxide solution. The specimens were cultured on Sabourad dextrose agar culture media containing chloramphenicol and cyclohexamid (Scc). For identifying the species of dermatophytes, complementary tests were used. Frequencies and relative frequencies were demonstrated in tables and chi-square and Fisher's exact tests were used to investigate any association between the categorical variables. Results: Of 700 dystrophic nail samples, 53 samples (7.6%) were positive according to both direct examination and culture. Thirty-eight patients were males. The most common clinical type was distal subungual onychomycosis which was observed in 79.2% of cases. The most frequent detected dermatophyte species. was T. interdigital (39.6%) followed by T. rubrum (37.7%). Forty-seven patients had tinea unguium on their toe nails, 4 patients on their finger nails, and 2 patients had it on both finger and toe nails. Nineteen patients had underlying diseases, and the most common underlying disease was cardiovascular disease (26.3%). Conclusion: Tinea unguium is a disease with worldwide distribution and identifying the causative agents and predisposing factors are necessary for better management of the patients.
Antifungal susceptibility to azoles drugs in Candida species isolated from patients with onychomycosis
Ensieh Lotfali, Zahra Cheraghi, Yasamin Farzaneh, Zakieh Dehbashi, Mahtab Dorrian, Mahyar Keymaram, Azam Fattahi,
Volume 12, Issue 2 (Volume 12, No 2 2021)
Abstract

Background and Aim: Onychomycosis is an infection caused by yeast, filamentous and non-filamentous fungi, due to diverse conditions. This study aimed to investigate the pattern of azole susceptibility of candidate species isolated from Iranian patients in Tehran.

Methods: After sampling from patients, identification of the isolated strains were performed with Candida chrom agar medium and PCR-sequencing test. Drug Susceptibility pattern of the species to fluconazole, itraconazole and ketoconazole were determined by CLSI-M27-A3/S4 standard method.

Results: In this study, 34 candidate isolates were identified, of which 26 isolates (76.5%) were Candida albicans and 8 isolates (23.5%) were Candida glabrata. In fluconazole, 4 (11%) of the isolates were dose-dependent sensitive and the others were sensitive. In itraconazole, 21 (61%) dose-dependent isolates and 2 (5%) resistant isolates were identified, and in ketoconazole, all isolates were sensitive. The geometric mean (GM) of the minimum inhibitory concentration for fluconazole, itraconazole and ketoconazole was 0.32, 0.21 and 0.15 μg/mL, respectively. In this study, the most frequently isolated species was C. albicans. According to the GM values, the most effective azoles was ketoconazole.

Conclusion: The prevalence and pattern of susceptibility of Candida species to azole may vary in different populations of patients. Therefore, it is recommended that the clinicians pay attention to the results of drug susceptibility tests and then treat patients by considering drug interactions and side effects.


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