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Showing 2 results for Ghaedi
The effects of oral isotretinoin on sex hormones and menstrual cycle in women with severe acne
Nazi Saljoughi, Roghieh Jebraili, Setareh Tehrani, Masoumeh Yarjanli, Sepideh Tehrani, Forugh Ghaedi,
Volume 7, Issue 4 (Volume 7, Number 4 2017)
Abstract

Background and Aim: Acne vulgaris is a common skin disease and oral isotretinoin is the only  treatment that is dramatically effective on its severe type The aim of this study was to evaluate the effects of oral Isotretinoin on the level of sex hormones and menstrual cycle in female patients with severe acne.

Methods: In this before and after treatment study, 50 patients with severe acne vulgaris whom were referred to the dermatology clinic of Amir-Almomenin Hospital in Tehran  in 2015 and 2016, were recruited. The inclusion criteria were female gender, age between 18 to 50 years, and having severe acne. Exclusion criteria were: pregnancy, lactating, and suffering from other diseases which could confound the study results. The prescribed dose of the oral isotretinoin was 0.5 mg/kg/day for three months. Before initiation of treatment and  after three months of treatment serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, and total and free testosterone were measured and compared.

Results: The mean ± standard deviation (SD) age of the patients was 26.0 ± 7.1 years, and 10% of them had polycystic ovary syndrome (PCOs). After taking isotretinoin, 33 (66%) of patients had no change in their menstrual periods, while 3 (6%) had oligomenorrhea, 4 (8%) had amenorrhea, and 10 (20%) had dysmenorrhea. After treatment, mean serum LH levels significantly increased (P=0.001), but FSH, estradiol, and total and free testosterone serum levels did not change statistically (P>0.05).

Conclusion: This study showed that oral isotretinoin can increase the level of serum LH and cause changes in menstrual cycles.


Identification of key genes in melanoma metastasis and investigating their potential as biomarkers
Pegah Abbasi, Maryam Peymani, Dariush Farhud, Hamidreza Mahmoudi, Kamran Ghaedi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background and Aim: Considering the high global incidence of skin cancer and the high mortality rate caused by melanoma, it is important to identify the genes involved in this disease and predict effective drugs. Therefore, in this study, we have identified and investigated the expression level of effective and key genes in melanoma metastasis, as well as investigating their diagnostic potential as biological markers and finding effective drugs on the expression of these genes.
 
Methods: In this study, we have used 46 cancer samples without metastasis and 12 cancer samples with metastasis from the GEO database and from the GSE15605 study with 74 samples including 16 normal samples. Gene expression profile in this study was generated by GPL570 platform containing 54675 probes. The latest GPL570 annotation file has been downloaded and initial processing was done.
 
Results: The results showed that the expression level of candidate genes in metastasis samples had a significant change compared to normal samples. The results of analysing the data related to candidate genes in this study indicated that the drugs Glucosamine, Ad-E2F-1 plus Doxorubicn, GSI, Torcetrapib, Ribavirin and NSC319726 could be effective on the expression of MYH10, SPRR3 and TOP2A genes, respectively. On the other hand, the results from the drug bank database revealed that various drugs such as Amsacrine, Dexrazoxane, Valrubicin, Teniposide can have an inhibitory role on the TOP2A gene.
 
Conclusion: GEO database was used to identify key genes in melanoma metastasis and DRUGBANK was used to identify drugs that affect the expression of these genes.

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