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Amir Hooshang Ehsani, Mahbobeh Sadat Hosseyni, Amir Reza Hanifnia,
Volume 3, Issue 1 (3-2012)
Abstract

Background and Aim: Alopecia areata is a non-scarring hair disorder. Trace elements imbalance (like zinc) has been reported as its triggering factor. In this study we compared serum zinc level in alopecia areata patients with normal values.
Methods: Twenty-three female and 19 male patients with alopecia areata were recruited and their serum zinc levels were assessed using absorption spectrometery. Chi squared, t and ANOVA tests were used for statistical analysis.
Results: Sixteen patients with more extensive and prolonged disease, had serum zinc level lower than normal (70 µg/dL). The means of serum zinc levels in patients and normal population were 81.88 µg/dL and 83.5 µg/dL, respectively. This difference was not significant (P=0.668). The means of serum zinc level in different types of alopecia areata were not significantly different (P>0.05). There was an association between serum zinc level and disease duration (P=0.022).
Conclusion: Patients with more severe forms of alopecia areata had lower serum zinc level than other forms of the disease.

 


Amir Hooshang Ehsani, Mahboobeh Sadat Hosseyni, Kambiz Kamyab, Masoomeh Rohani Nasab, Amir Reza Hanifnia, Pejman Mobasher, ,
Volume 3, Issue 2 (6-2012)
Abstract

Background and Aim: Cicatricial alopecia is characterized by permanent destruction of the pilosebaceous unit, leading to irreversible hair loss, and has primary and secondary types. Primary type, based on predominant inflammatory infiltration in histology, is divided to neutrophilic, lymphocytic and mix types. Decalvans folliculitis, dissecting cellulitis and acne keloidalis are 3 subtypes of neutrophilic group. In this study frequency of each subtype and the distribution of age, gender and duration of disease have been reviewed.

Methods: This retrospective study was performed on patients with clinical diagnosis of cicatricial alopecia and histologic confirmation referred to Razi hospital in Tehran in 2005-2009.

Results: Of 135 patients with mean (mean±SD) age of 32±10.6 years, 71.9% were male and 28.1% were female. The diagnoses included decalvans folliulitis (72.6%) with mean age of 31.89 years, dissecting cellulitis (25.0%) with mean age of 32.4 years and acne keloidalis (1.5%) with mean age of 52 years. The mean duration of disease was 4.2±3.9 years (4.08 years in male and 4.7 years in female). The mean duration of disease in decalvans folliulitis was 4.7, in dissecting cellulitis was 1.9 and in acne keloidalis was 17.5 years.

Conclusion: Neutrophilic scarring alopecia is more common in men and in the third decade of age and the most common type is decalvans folliulitis.



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