Showing 8 results for Iman
Shiva Golmohammadzadeh, Mahmoud Reza Jaffari, Hossein Hosseinzadeh, Fatemeh Imani,
Volume 1, Issue 1 (3-2010)
Abstract
Background and aim: Saffron possesses a lot of medical applications in traditional medicine. One of its properties is ultraviolet (UV) light absorption. The aim of this study was preparation, determination of properties and investigating sun protevtive effects of nanoliposomes containing saffron extract and safranal, a substance existing in saffron.
Methods: Nanoliposomal hydroalcoholic extract of saffron stigma in concentrations 2%, 4%, 8% and nanoliposomal safranal in concentrations 0.25% , 0.5% and 1% were prepared. Standard lotion of homosalate 8% was used according to FDA standards for sun protection factor (SPF) determination and assessment of accuracy of the method. SPFs of substances were calculated in vitro by diluted solvent method using Mansur, et al equation and absorptiometry.
Results: SPf of Nanoliposomal saffron 8% extract was significantly higher than standard sunscreen homosalate with similar concentration. SPFs of safranal (1% and 0.5%) component of saffron were significantly higher than the standard sunscreen homosalate 8%.
Conclusion: Saffron can act as a sunscreen. Safranal existing in saffron is much more sun protective than standard substance, homosalate 8%. Thus , the safranal existing in saffron may have significant sun protective effect in low concentration if encapsulated in liposome.
Isa Khaheshi, Saeeid Keshavarz, Majid Shohrati, Abbasali Fooladi Imani, Mohammadreza Nourani,
Volume 1, Issue 4 (12-2010)
Abstract
Background and Aim: As a blistering agent, mustard gas causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like pruritus. TGF-β1 molecule is a cytokine with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-β1 gene exprtession in victims exposed to mustard gas and the correlation with the severity of their pruritus.
Methods: 17 victims exposed to mustard gas, 17 patients with chronic contact dermatitis and 10 healthy individuals were included in the study. The assessment of TGF-β1 expression in their skin samples was conducted by semi-quantitative RT-PCR followed by immunohistochemistry and classification of patients was done by pruritus severity scoring system (0-3).
Results: There was a significant decrease in TGF-β1 gene expression in mustard gas exposed victims comparing to chronic contact dermatitis group and the control group (P<0.05). In addition, in the absence of TGF-β1 expression, the severity of pruritus in the patient group significantly increased (P<0.05).
Conclusion: TGF-β1 has a significant role in chronic inflammatory skin lesions caused by mustard gas.
Iman Ahrari, Ladan Dastgheyb, Zahra Ghazi, Maryam-Ol-Sadat Sadati,
Volume 3, Issue 3 (9-2012)
Abstract
Background and Aim: Tinea capitis is one of the most common fungal infections in dermatology. Although the new medications and development in social health have reduced its incidence, it is still common in Iran, especially in rural areas. The aim of this study was to describe the frequency of complications of kerion.
Methods: Eighteen affected patients, who were hospitalized in dermatology ward because of kerion, in a 10-year period, were revisited and according to their medical documents, data collection forms were filled.
Results: 61.1% of the patients were younger than 10 years of age and 77.7% were male. The mean disease duration from the onset of symptoms to the time of correct diagnosis and management was 16.9 days. The frequency of scar and alopecia was equal in all groups and occurred in 100% of patients. Two patients also suffered from isolation due to scarring alopecia. Various types of medications, made no difference in the prognosis and resultant scarring alopecia.
Conclusion: The frequency and types of sequela showed no relationship with age, type of medication and duration from the onset of disease and correct management. Scar and alopecia occurred in all patients. Further investigations on the new treatment modalities are required to reduce scar formation.
Seyede Hamide Razavi, Roholah Ghasemi, Maryam Iman,
Volume 7, Issue 1 (Volume 7, Number 1 2016)
Abstract
Transdermal drug delivery (TDD) is a non-invasive, topical administration method for therapeutic agents. Transdermal delivery also has advantages including providing release for long periods of time, improving patient compliance, and generally being inexpensive. Despite these advantages, the use of TDD has been limited by innate barrier functions of the skin. Only small (<500 Da), lipophilic molecules can passively diffuse through the skin. As a result of the barrier function of the skin, passive transdermal delivery has primarily been limited to small molecules. The skin, which consists of several layers including the stratum corneum, other epidermal layers, and dermis, is the primary defense system of the body. The main barrier to therapeutic delivery is the outermost layer of the skin, the stratum corneum. As a result, various methods of skin permeabilization have been explored for their ability to enhance the transport of drugs across the stratum corneum. Scientists evaluated new drug delivery systems such as nano-carriers and drug delivery systems and enhancer methods such as penetration enhancers. The purpose of drug delivery systems are to deliver sufficient drug molecules into the skin with maximum stability and minimal toxicity. To guarantee successful transdermal drug delivery, a drug delivery system must exhibit several essential properties including drug protection, targeted drug delivery, biocompatibility and biodegradability.
This paper reviews transdermal drug delivery systems, recent enhancement techniques to optimize drug delivery such as microneedles and especially vesicular systems. Herein, we focus on the differences in their composition, physico-chemical properties and applications of those drug delivery systems. We hope recent innovations can work as a foundation for further research and development in transdermal drug delivery system.
Iman Bagherpour, Razieh Zare,
Volume 8, Issue 3 (Volume 8, Number 3 2017)
Abstract
Background and Aim: Considering the prevalence of sunburn and its complications and the importance of preventing it, we conducted a study to compare a brand sunscreen with SPF = 60 (cream A) and a domestic sunscreen with SPF = 50 (cream B) in hikers.
Methods: The clinical trial was carried out on 50 participants in shiraz. 0.4 ml of the cream A was applied to one side of face and the same amount of cream B was applied to other side as control. The participants were exposed to the sun for 5 hours. The assessment was performed 3 hours after the onset by a dermatologist and 24 hours later by the participants themselves based on erythema, burning, itching and satisfaction with the products. The data were analyzed using McNemar and chi-square tests.
Results: Cream B in 82.2% and A in 76.2% of cases prevented sunburn. Also, the participants' satisfaction was 95% and 82% for using B and A creams, respectively. Sunscreen A and B did not show significant difference in prevention of sunburn, but side effects such as burning and itching were observed more in cream A and paricipants satifaction was more with cream B.
Conclusion: Overall cream B had less side effects and participants were more satisfied with it.
Keyvan Ezimand, Ataolah Abdolahi Kakroodi, Mohammad Javanbakht,
Volume 9, Issue 1 (2018, Volume 9, Number 1 2018)
Abstract
Background and Aim: Environmental and climatic conditions in different geographical areas provide the basis for certain diseases. Skin cancer is one of the most common types of cancer, with a different incidence rate in geographical areas. The aim of this study is to determine the effects of climate and environmental factors on skin cancer and to map the geographical distribution of skin cancer in Iran.
Methods: This study was performed using data of patients with skin cancer, population and data of climatic and environmental factors that affect skin cancer incidence. In this study, after calculating the incidence of skin cancer rate for the whole country, we used the Geographically Weighted Regression model to establish a regression relationship between climate and environmental data and the incidence of skin cancer. The coefficient of detection between the map of incidence of skin cancer and its model map was calculated.
Results: Correlation coefficients showed that sun UV and relative humidity had the highest positive and negative correlation with the incidence of skin cancer, respectively. The southern, eastern and central regions of Iran had the highest incidence of skin cancer rate and the northern and northwestern coasts of Iran had the lowest incidence rate. Validating of actual incidence rate map and the modeled incidence rate map indicated a coefficient of detection of 0.71.
Conclusion: All of the climate and environmental parameters in this study contributed to in the incidence of skin cancer.
Behnaz Shojaedin Givi, Ali Khamesipour, Hossein Naderimanesh,
Volume 10, Issue 2 (2019, Volume 10, Number 2 2019)
Abstract
Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a model in skin infections.
Methods: In this study, microneedles were fabricated by three-step molding method, which included master mold making, polymeric matrix that blending of polyvinyl pyrrolidine and methacrylic acid and finally casting.
Results: The identification of Amphotericin-B in polymeric microscopic compositions was investigated by absorption and emission spectroscopy. Also, the mechanical strength of microneedles, which confirms their ability to penetrate the skin, was investigated by a transducer.
Conclusion: In this study, the design and fabrication of a skin-permeable polymeric microneedle array with biodegradability and biocompatibility characteristics in physiological environment was performed. Using the properties of designed needles, loading of Amphotericin-B was used for the treatment of leishmaniasis and skin fungal infections.
Mahdieh Ghiasi, Seyedkhalil Pestehei, Seyedamirhossein Javadi, Seyediman Seyhoun,
Volume 15, Issue 1 (Volume 15, No 1 2024)
Abstract
The skin, as the outer layer, protects the body against external factors. Wounds can negatively affect its performance. Wound healing includes three stages of inflammation, proliferation, and regeneration, which begin immediately after injury. Also, some factors such as infection, obesity and diabetes can disrupt the natural healing process that leads to chronic wounds. Various surgical and non-surgical treatments have been used to manage chronic wounds, including hyperbaric oxygen therapy, ultrasound therapy, laser therapy, and skin grafting. These treatments have advantages and disadvantages. Recently, stem cells have been used as a surgical treatment for chronic wound healing. Stem cells are highly proliferative cells that can maintain their ability to divide and regenerate for a long time. Among the different types of stem cells, MSCs have many advantages such as ease of harvest, availability, and multilineage differentiation capacity for cell therapy. In addition, they showed some properties that could be useful in the clinical application of ASCs, including angiogenesis, immune system modulation, and improved tissue regeneration. This study was conducted by collecting data from reliable scientific sources from April 1401 to January 1402 at the Research Institute of Neurosciences, Brain and Spinal Cord Injury Research Center of Tehran University of Medical Sciences. Several studies have shown that ASCs can be a suitable candidate for wound healing due to their special characteristics. The purpose of this review is to discuss the use of ASCs in wound repair and healing as a new strategy in the treatment of skin problems.
