Showing 11 results for Karimi
Farzad Jalilian, Mohammad Ahmadpanah, Mehrdad Karimi, Iraj Salehi, Ali Asghar Vahidinia, Shohre Emdadi,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: High consumption of cosmetic products may result in several health problems. Cosmetics use among Iranian girls and women is common, so identifying factors affecting cosmetic use seems necessary. The aim of this study was to determine the prevalence and reasons for cosmetic products use among female university students.Methods: This cross-sectional study was carried out on 540 female university students of Hamedan universities, which were recruited according to a random sampling method. The data gathering tool was a self-reporting questionnaire.
Results: Lipstick (62.2%), mascara (50.9%) and liner (43.3%), were the most commonly used products among students. Feeling beautiful and improved self-confidence were the most common reasons for using cosmetic products.
Conclusion: Considering the findings of this study, it seems that providing educational programs for promotion of self-esteem can be beneficial for preventing unnecessary cosmetic use.
Nafiseh Esmaeili, Amirhooshang Ehsani, Mehdi Mohseni-Badalabadi, Kambiz Kamyab, Abbas Karimi,
Volume 3, Issue 4 (12-2012)
Abstract
Background an Aim: parapsoriasis is a rare chronic
idiopathic dermatosis which commonly manifests with round or oval scaling and
itching erythematosus plaques on trunk and extremities. Considering the size of
the lesions, parapsoriasis is divided into two groups: small plaque and large
plaque. Study of demographic characteristics of this disease may help to
identify the high risk groups who are more susceptible to cutaneous lymphoma
with high mortality as well as proper allocation of health service resources.
Methods: In this retrospective cross-sectional study,
affected parapsoriasis patients whom were referred to Razi Hospital in Tehran between
April 2003 to March 2009 were studied. Three hundred and twenty patients were
investigated for variables: age, sex, place of residence, location of the lesions
and clinical subgroups according to the histopathology reports.
Results: 53.4% of patients were female. The disease was most
commonly observed in age group of 20 to 50 years and the mean age of the patients
was 43.3 years. Eighty-five percent of the patients were inhabitant of Tehran
province. 88.1% of patients had large plaque lesions and 11.9% had small plaque
lesions. The most common sites of lesions were on the trunk (53.4%) followed
by the extremities (38.7%).
Conclusion: Based on these findings, it was determined that
parapsoriasis most commonly affects middle-aged women. Involvement of trunks and
extremities were most commonly observed. Large plaque type was the most common
type.
Nafiseh Esmaeili, Md, Zahra Halaji, Md, Amirhooshang Ehsani, Md, Mahboubeh Eghbalian, Md, Abbas Karimi,
Volume 4, Issue 2 (6-2013)
Abstract
Background and Aim: Alopecia Areata is a chronic inflammatory disease which involves hair follicles. The aim of this study was to assess the efficacy of oral sulfasalazine in the treatment of recalcitrant alopecia areata.
Methods: Patients with refractory alopecia areata who were eligible for the study, after providing informed consent were treated with oral sulfasalazine for 6 months. After completion of treatment, regrowth of vellus and terminal hairs were determined based on clinical examination and comparing the new photographs with the baseline ones.
Results: Sixteen patients were enrolled in the present study but only 5 patients completed it. No response was seen in 3 patients. After 4 months, 55-60% response to treatment was observed in 1 patient, but the disease relapsed at the end of fourth month. In 1 patient, 15% hair regrowth was observed but treatment was discontinued after the second month due to side effects. Side effects were observed in 2 patients.
Conclusion: Since only refractory alopecia areata patients had been enrolled to the study, the results could not be generalized to all patients with alopecia areata. Therapeutic response in the patients with alopecia areata is disappointing and any poor treatment response or failure of treatment in refractory cases of the disease cannot rule out the efficacy of the drug in the milder forms of the alopecia areata.
Nafiseh Esmaeili, Mansoureh Akhavan, Hossein Mortazavi, Abbas Karimi,
Volume 4, Issue 3 (9-2013)
Abstract
Background and Aim: Bullous pemphigoid is an acquired
autoimmune disease with subepidermal blisters commonly seen in the elderly over
60 years old. The exact survival rate of the patients with bullous pemphigoid
was not available in Iran. The aim of this study was to evaluate the risk
factors of 5-year mortality of bullous pemphigoid patients.
Methods: In this retrospective study, 66 bullous pemphigoid
patients referred to Razi hospital from 1986 to 2006 were studied. Age, sex,
consumed corticosteroid type, duration of hospitalization, and clinical form of
bullous pemphigoid, ESR and comorbidities were evaluated to determine the risk
factors associated with patients’ 5-year mortality rate.
Results: Forty-seven patients (71.2 %) had
5-year survival. The most common comorbidities were cardiovascular diseases
(28.8%), diabetes (15%) and chronic respiratory diseases (9%). There was a significant
relationship between the age and the 5-year survival rate, in other words
patients aged over 70 years had a less 5-year survival rate (P<0.001). There was no statistically
significant association with gender, the type of corticosteroid, the disease clinical
forms, duration of hospitalization or ESR and 5-year survival (P>0.05).
Conclusion: The current study found a
significant relationship between the age of the patients and 5-year survival. Larger
studies considering more potential risk factors and more appropriate designs
might help to estimate the survival rate of patients with bullous pemphigoid
more precisely.
Tahereh Soori, Nafiseh Esmaeili, Mostafa Mirshams-Shahshahani, Mohammad Reza Poursadati, Abbas Karimi,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
Background
and Aim: The standard treatment regimen for pemphigus is
adminitration of systemic corticosteroids and adjuvant agents. Previous studies
have shown that corticosteroid therapy may alter lipid profile and reduce the
atherogenic index in some disorders. This study was conducted to evaluate
the changes in lipid profile in pemphigus patients treated with oral
corticosteroids alone or in combination with adjuvants.
Methods:
In this retrospective corss-sectional study, medical records of 148 pemphigus
patients admitted in Razi Hospital in Tehran were reviewed for serum levels of
low-density lipoprotein (LDL), high-density lipoprotein (HDL), total
cholestrol, and triglyceride on the day of admission till 3 weeks after
initiation of the treatment.
Results:
Fifty-eight percent of patients were female and the mean age of the patients
was 47.1 years. 79.3% and 13.3% of patients had been treated with prednisolone
plus azathiorine or prednisolone alone, respectively. The remainig patients
were treated by administration of oral prednisolone and other adjuvants. Serum
levels of LDL, HDL, total cholestrol and triglyceride were significantly higher
3 weeks after initiation of treatment compared to baseline (P<0.05). With
the exception of the signifcantly higher level of triglycerides in women, there
was no statistically significant association between the levels of other serum
lipids at the end of 3 weeks treatment with gender, age, severity of the
disease, use of statins, and the treatment regimen (P>0.05).
Conclusion:
Although the level of different components of the lipid profile in Iranian
patients with pemphigus changed after receiving treatment for 3 weeks, it seems
that those changes were not associated with an increased atherogenic index of
pemphigus patients.
Nafiseh Esmaeili, Sedigheh Talebi, Kambiz Kamyab, Abbas Karimi,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
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Background
and Aim: Bullous pemphigoid (BP) is an acquired autoimmune
disease with subepidermal blisters commonly seen in the elderly over 60 years.
Although the disease is usually manifested with tense blisters, but in some
cases generalized pruritus is the only symptom of disease, which is less
studied.
Methods: In
a retrospective study, the medical records of 416 BP patients confirmed in pathology
laboratory were evaluated for clinical findings, direct immunofluorescence
(DIF) testing for BMZ-binding IgG antibodies and histological findings.
Results: Of
the 416 confirmed BP patients, 213 were male and 203 were female. The mean
age of patients was 64.36 years. Thirty four patients at the onset of the
disease had generalized pruritus, which in the course of the disease, 29
patients also showed other symptoms of the disease. In 5 patients generalized
pruritus was seen as the only symptom. Concerning to the results of DIF, 117
(90%) patients showed autoantibody deposit, and in 13 (10%) patients the test
was negative. There was no significant relationship between DIF results and
histological findings (p> 0.05).
Conclusion: According to the findings of
this study, generalized pruritus is uncommon as the first symptom of the
disease. There was not any association between generalized pruritus and
histological observations including dermal edema, presence of eosinophils in
tissue, subepidermal blister as well as DIF results. Further studies on the
early detection of the disease are required to decrease complications of the
disease.
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Afagh Kazemi, Omid Eskandari, Mohammad Karimi,
Volume 6, Issue 1 (Volume 6, Number 1 2015)
Abstract
Background and Aim: Skin cancer is one of the most common human cancers. Its incidence rate trend is increasing in Iran. The aim of this study was to investigate the prevalence, incidence rate and geographical distribution of skin cancer to identify the high risk areas in Kurdistan province, Iran.
Methods: In this descriptive cross-sectional study, the collected data were analyzed using version 16 of SPSS software, and t-test and analysis of variance (ANOVA) were used for comparison of the means. The distribution map of skin cancer in the province was prepared using Geographic Information System (GIS) software, version 9.3 between the beginning of 2006 and the end of 2010. In order to investigate the reason for high rates of skin cancer in some cities, ultraviolet (UV) radiation distribution map was also prepared.
Results: Sanandaj with 17.55/100000 had the highest and SarvAbad with 3.73/100000 had the lowest incidence rates. The number of male patients (542) was nearly two times of female cases (324), (P<0.0001). In addition, skin cancer was about two times more prevalent in urban (%68.01) than rural (%31.99) residents (P=0.008).
Conclusion: Life style of men and their sun exposure because of their job seemed to be a major risk factor in increasing the incidence of skin cancer in Kurdistan province, Iran. There was no correlation between the skin cancer incidence at the district level and UV index. Further research is recommended to explain this finding.
Nafiseh Esmaeili, Tahereh Soori, Zeinab Nooraei, Abbas Karimi,
Volume 6, Issue 2 (Volume 6, Number 2 2015)
Abstract
Background and Aim: Pemphigus vulgaris is a rare autoimmune intraepidermal blistering disease affecting the skin and mucous membranes. Copper and zinc are two necessary trace elements in the human body that have antioxidant activity in the wound healing process. The aim of this study was to determine the serumic level of zinc and copper in newly diagnosed patients with pemphigus vulgaris.
Methods: In this study, 50 newly diagnosed patients with pemphigus vulgaris admitted to Razi Hospital in Tehran were studied with regards to their serum levels of copper and zinc alongside age, sex, body mass index (BMI), smoking and drug abuse status.
Results: Eighteen percent (9 cases) and 50% (25 cases) of the patients showed copper and zinc deficiency, respectively. There was no significant association between copper and zinc levels and smoking, age, BMI or suffering from a chronic disease (P>0.05). Mean copper levels in women and men were not significantly with their respective different normal levels (P>0.05). Serum zinc level in men was lower than its normal range (P<0.05), but in women was not significantly different from its normal level.
Conclusion: Serum concentration of copper and zinc did not show any association with pemphigus disease. Since decreased levels of copper and zinc may result in an increase of oxidative activity in autoimmune diseases enhancing disease severity, therefore conducting a robust case-control study for evaluating the their roles in disease severity may pave the way to treatment of those diseases.
Nafiseh Esmaeili, Tahereh Soori, Nooshin Shirzad, Maryam Vahid-Moghadam, Abbas Karimi,
Volume 6, Issue 3 (Volume 6, Number 3 2015)
Abstract
Background and Aim: Pemphigus vulgaris is the most common autoimmune blistering disease. Prednisone, commonly in combination with an immunosuppressive adjuvant such as azathioprine or cyclophosphamide, is the standard treatment for pemphigus vulgaris. Approximately 5% to 15% of mortality of the disease is due to the complications of corticosteroids therapy. The aim of this study was to determine the prevalence and risk factors of steroid-induced diabetes in pemphigus patients hospitalized in Razi hospital, Tehran in 2009 and 2010.
Methods: In this cross-sectional study, 177 first-time admitted pemphigus vulgaris patients were studied regarding presence of risk factors for steroid-induced diabetes. Those risk factors were included age, sex, blood pressure, body mass index (BMI), family history of diabetes, medications used before and after initiation of treatment, fasting blood sugar (FBS) , triglyceride (TG) high density lipoprotein (HDL), low density lipoprotein (LDL) levels at the time of admission, and three weeks after the treatment was started.
Results: Twenty-nine patients (16.3%) were diagnosed with diabetes based on three weeks FBS levels evaluations. There were significant associations between BMI, HbA1c and taking nervous system agents and diabetes (P<0.05), but the differences between sex, family history, blood pressure, TG, LDL levels and occurrence of diabetes were not significant (P>0.05).
Conclusion: Close monitoring of FBS levels before and within the first three weeks of the initiation of steroid therapy allows early detection of storied-induced diabetes in pemphigus patients. Moreover, evaluation of other risk factors associated with diabetes may provide the opportunity of early diagnosis and treatment of steroid-induced diabetes.
Nafiseh Esmaeili, Zahra Karimi, Tahereh Soori, Abbas Karimi,
Volume 6, Issue 3 (Volume 6, Number 3 2015)
Abstract
Background and Aim: Pemphigus is a chronic autoimmune blistering disease characterized by intraepidermal blisters.
These blisters damage the skin barrier and increase the risk of life-threatening infections. Nasal colonization of
Staphylococcus aureus can increase the risk of infections and delay the wound healing process.The aim of this study was to
determine the frequency of staphylococcal carriers in hospitalized patients with pemphigus.
Methods: In this prospective cross-sectional study, medical records of 72 hospitalized patients with pemphigus in the
period from March 2013 to March 2014 were reviewed.Samples were collected from anterior nares and cultured at the
time of admission and one week after hospitalization for evaluation of S. aureus colonization and Methicillin-resistant
Staphylococcus aureus (MRSA) types.
Results: Forty-five patients (62.5%) were male and 27 patients (37.5%) were female. The frequency of S. aureus
carriers was 58.3%. Thirty patients had colonization at the time of hospital admission among them, 22 (73.3%) patients
had MRSA. In forty (55.6%) patients colonization were found one week after hospitalization. Thirty-three (82.5%) patients
in this group were MRSA positive. There was no significant difference between S. aureus colonization at the time of
admission and one week after hospitalization (P>0.05).
Conclusion: S. aureus and MRSA carriers (communityacquired and hospital-acquired carriers) were prevalent
among patients with pemphigus. With identifiction and isolation of carriers of S. aureus in pemphigus patients, not
only could prevent spreading S. aureus and MRSA associated infections, bul also would facilitate wound healing. More
robust studies are required to assess the role of potential riskfactors.
Zahra Karimi, Anahita Khodabakhshi Koolaee, Amir Houshang Ehsani,
Volume 7, Issue 3 (Volume 7, Number 3 2016)
Abstract
ackground and Aim: Vitiligo is a chronic skin disease which manifests with depigmented patches as a result of absence of skin melanocytes. Vitiligo results in beauty problems which could cause mental disorders. The purpose of this research was to compare the tendency to suicide and stress in patients with vitiligo with those without any skin disease.
Methods: For conducting this research, 30 patients with vitiligo who were referred to the Behsima Skin and Laser Clinic in Tehran during 2016 were recruited. Data were collected using Beck suicide scale ideation and Kohen stress questionnaires. Thirty demographically-matched individuals without active skin disease over the past six months were recruited into the study as the control group.
Results: Mean±standard deviation (SD) of Beck suicide scale ideation (BSSI) score in patients with vitiligo was 3.67±1.33, significantly higher than 0.37±0.17 in the control group (P=0.02). Mean scores of stress in vitiligo patients was 28.33±9.20, which was also higher than the control group mean, 21.77±8.19 (P=0.005).
Conclusion: Patients with vitiligo had more suicide ideation and stress than normal population. So, in taking care and treating in vitiligo patients, a special attention to the psychological effects of disease on the lives of the patients is recommended.
