Search published articles


Showing 2 results for Layegh
Clinical and laboratory adverse effects of oral isotretinoin in patients with nodulo-cystic acne
Pouran Layegh, Hesamolddin Saeedian, Mahnaz Banihashemei, Habibollah Esmaeilee, Akram Momenzadeh,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: Oral isotretinoin is the only drug that is effective on almost all factors involved in the pathogenesis of acne. Although several studies have been conducted on side effects of this drug, few studies have been conducted on Iranian patients. The aim of this study was to evaluate common clinical and laboratory side effects of this drug in patients with nodulo-cystic acne in Mashhad, Iran.
Methods: One-hundred nodulo-cystic acne patients without previous history of hematologic, renal or hepatic diseases and with negative pregnancy tests (in female patients) were enrolled to this study. Patients were treated with standard regimen of oral isotretinoin with a cumulative dose of 120 mg/kg for a treatment course. Demographic data of each patient and results of baseline laboratory tests including serum lipids profile, liver function tests and cell blood counts were recorded.Laboratory tests and the clinical side effects were assessed every two months.
Results: All patients completed treatment course. The most common side effects were cheilitis (87%), dry skin (71%), various types of dermatitis (37%), epistaxis (21%), arthralgias and myalgias (21%). All side effects were mild and treatment discontinuation was not necessary in any case. Although some changes were observed in serum lipid profiles and liver function tests, but these changes were within normal range.
Conclusion: Treatment with oral isotretinoinis associated with few complications in patients with nodulo-cystic acne, but the possibility of serious side effects should always be considered.

Comparison of free salivary testosterone versus free serum testosterone levels in patients with hirsutism and control group
Pouran Layegh, Zari Javidi, Parvin Layegh, Bita Kiafar, Saber Shojaei Nouri, Akram Momenzadeh,
Volume 3, Issue 4 (12-2012)
Abstract
Background and Aim: Hirsutism is defined as male pattern hair growth in females which affects 10% of women. Our aim was to compare free salivary and free serum testosterone levels in women with hirsutism and healthy controls.
Methods: This study was a case-control study in which 30 hirsute women in child bearing age were recruited and compared with 10 healthy controls. For each patient, a questionnaire containing demographic, clinical and laboratory information was completed. The salivary and serum total and free testosterone plus free androgen index were measured by radioimmunoassay (RIA) method. The collected data were described and analyzed using SPSS software version 11.5. Significance level was determined at 0.05.
Results: No significant correlation was seen between salivary and serum free testosterone and in free androgen index with free testosteron in patients and control groups. Comparing the results between case and control groups, except for mean serum total testosterone level (P<0.05), the other results were not significantly different. No significant correlation was seen between hirsutism severity and free serum or salivary testosterone levels. Significant correlation was seen with total serum testosterone (P<0.001). Investigating correlations between these hormones with serum free androgen index, only salivary free testosterone was correlated with this index (r=0.01, P<0.05).
Conclusion: In our study, we find no correlation between free serum and salivary testosterone, so it seems that this evaluation method is not an appropriate alternative for serum evaluation of this hormone.
Page 1 from 1     

© 2025 , Tehran University of Medical Sciences, CC BY-NC 4.0

Designed & Developed by : Yektaweb