Showing 5 results for Mortazavi
Nafiseh Esmaeili, Mansoureh Akhavan, Hossein Mortazavi, Abbas Karimi,
Volume 4, Issue 3 (9-2013)
Abstract
Background and Aim: Bullous pemphigoid is an acquired
autoimmune disease with subepidermal blisters commonly seen in the elderly over
60 years old. The exact survival rate of the patients with bullous pemphigoid
was not available in Iran. The aim of this study was to evaluate the risk
factors of 5-year mortality of bullous pemphigoid patients.
Methods: In this retrospective study, 66 bullous pemphigoid
patients referred to Razi hospital from 1986 to 2006 were studied. Age, sex,
consumed corticosteroid type, duration of hospitalization, and clinical form of
bullous pemphigoid, ESR and comorbidities were evaluated to determine the risk
factors associated with patients’ 5-year mortality rate.
Results: Forty-seven patients (71.2 %) had
5-year survival. The most common comorbidities were cardiovascular diseases
(28.8%), diabetes (15%) and chronic respiratory diseases (9%). There was a significant
relationship between the age and the 5-year survival rate, in other words
patients aged over 70 years had a less 5-year survival rate (P<0.001). There was no statistically
significant association with gender, the type of corticosteroid, the disease clinical
forms, duration of hospitalization or ESR and 5-year survival (P>0.05).
Conclusion: The current study found a
significant relationship between the age of the patients and 5-year survival. Larger
studies considering more potential risk factors and more appropriate designs
might help to estimate the survival rate of patients with bullous pemphigoid
more precisely.
Hossein Mortazavi, Farid Abbasi, Maryam Koopaie, Nafise Esmaeili,
Volume 5, Issue 2 (Volume 5, Number 2 2014)
Abstract
Background and Aim: Pemphigus vulgaris (PV) is the most common bullous autoimmune disease, which can cause mortality and morbidity in the patients who suffer from it. Researches to find reliable noninvasive laboratory tests to diagnose and monitor PV patients are being conducted.The aim of this study is to find the sensitivity of serum and salivary anti-DSG1 and anti-DSG3 antibodies in the diagnosis of PV by ELISA and to compare the results of serum and salivary autoantibodies with each other.
Methods: In this case-control study, 40 newly diagnosed patients with PV were recruited. Forty healthy controls were also recruited to this study. The clinical diagnosis of PV was confirmed by histopathology and direct immunofluorescence (DIF). Demographic data, disease severity and phenotypes were recorded on the questionnaires, which were developed for this study. DSG1 and DSG3 ELISA test were performed on serum and salivary samples of patients and controls.
Results: The mean±standard deviation age of patients, 43.37±11.94, with a range of 26 to 71 years. The sensitivities of serum anti-DSG3 and anti-DSG1 were 85% (34 cases had positive test results) and 90%, (36 cases had positive test results) respectively. The sensitivities of salivary anti-DSG3 and anti-DSG1 antibodies were accordingly 42.5% (17 cases had positive test results) and 60%, (24 cases had positive test results) respectively.
Conclusion: While the sensitivities of serum ELISA in detection of anti-DSG1 and anti-DSG3 were significantly higher than those of salivary ELISA, since the levels of the latter are chnaging in parallel to those of serum ELISA, they might be used to monitor the disease activity.
Alireza Khatami, Alireza Firooz, Fathieh Mortazavi, Ramin Homayouni Zand, Yahya Dowlati,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
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Background and Aim: Board
certification in any specialty is associated with a better professional
reputation as well as some other advantagessuch as the opportunity of working
as an academician. Accuracy of any test in the assessment of its participant
performance is of paramount importance. One of the main factors regarding
test accuracy is its validity.The aim of this study was to investigate the
views of the Iranian Board of Dermatology Examination Committee (IBDEC)
Members onimproving its validity.
Methods: This study was a
cross sectional survey. In order to extract the items for development of the
instrument for the survey, unstructured individual interviews were conducted
with two members of the IBDEC, two faculty members who were not members of
the IBDEC, and two resident dermatologists. Afterperforming a content
analysis, writing the items, and making revisions in accordance with the
expert panel suggestions, the face and content validities of the developed
instrument were confirmed by the panel. The instrument was distributed among
the members of the IBDEC in September 2013. The collected data were entered
into a data set.
Results: Fifteen of 16
present members of the IBDEC answered and returned the instrument to the
distributer. Ten (%66.7) of participants were male. Mean (standard deviation
[SD]) of age and membership duration in IBDEC of the participants were 56.1
(7.8) and 9.6 (6.2) years, respectively. The most difficult and easiest items
for being agreed upon were: "Inclusion of key feature problems (KFP) in
the written examination may result in better assessment of the residents'
clinical decision making" and: "In the board examination, attitudes
of the residents towards ethical issues are assessed properly".Cronbach's
α was calculated for assessment of the internal consistency of the instrument
and was equaled to 0.76.
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Conclusion: While 53% of the IBDEC
members were disagree with that the written board examination can assess
residents' different levels of knowledgeproperly, the majority of them were
also disagree with the implementation of suggested approved methods for
improving the validity of the written board examination. Most of them were also
disagree with implementation of evaluation methods for improving oral
examination validity.
Amir Houshang Ehsani, Hossein Mortazavi, Pedram Noormohammadpour, Arghavan Azizpour, Sara Rostami, Maryam Nasimi,
Volume 7, Issue 2 (Volume 7, Number 2 2016)
Abstract
Background and Aim: Acne vulgaris is a common skin disorder. This study was conducted to evaluate the impact of Ramadan fasting on acne healing in patients admitted to the dermatology clinic, Razi Hospital, Tehran.
Methods: In this prospective cohort study, 10 fasting persons (9 women and 1 man) and 10 non-fasting persons (9 women and 1 man) with acne were studied. Their baseline acne severities were recorded and acne improvement was evaluated in both groups after Ramadan month.
Results: Acne improvement was 71% in fasting persons and 49% in non-fasting persons. Improvement in fasting persons i.e. was 1.4 times of non-fasting ones (P=0.158). However, no significant statistical difference was detected. Also, it was determined that improvement was different according to acne grading. Improvement in acne lesions in patients with grade 2 severity was 100%, in those with grade 3 acne was 78%, and in patients with grade 4 acne was 35 % (P=0.025). But in non-fasting patients there was not a statistical difference between acne severity and improvement rate. Furthermore in patients younger than 24, improvement rate of acne was 1.6 fold more than non-fasting persons and in patients older than 24, this ratio was 1.3 (P=0.011).
Conclusion: This study did not show any statistically significant difference in acne improvement between who were fasting and who were not during Ramadan. Studies with larger sample size are recommended.
Elahe Nazari, Kambiz Kamyab Hesari, Sahar Montazeri, Nazanin Mansourzadeh, Vida Feizi, Hossein Mortazavi, Alireza Ghanadan, Nafiseh Esmaeli,
Volume 13, Issue 1 (Volume 13, No 1 2022)
Abstract
Background and Aim: Direct immunofluorescence (DIF) is represented as a gold standard method in diagnosis of autoimmune blistering dermatoses. Normal saline, liquid nitrogen and michel’ solution are a widely accepted media for preserving biopsy samples of skin or mucosa before DIF examination. Occasionally clinicians put the biopsy specimen taken for DIF in formalin 10%, occasionally clinicians ordered DIF retrogradely and only a paraffin-embedded biopsy specimen exposed to formalin 10% is available. To determine the diagnostic value of DIF when it was performed on biopsy samples of skin or mucosa exposed to formalin 10% in comparison to the same biopsy samples exposed to normal saline.
Methods: In 74 patients (38 immunobullous and 23 chronic dermatitis), which the latter served as the normal controls, 2 perilesional punch biopsy of skin or mucosa were done, one put in formalin 10% and fixed in paraffin and one put in normal saline, and DIF was done on both samples.
Results: DIF sensitivity and specificity was with IgG 31.5% and 100% in pemphigus and 15.36% and 93.44% in BP, with C3 39.47% and 100% in pemphigus and 7.69% and 91.80% in BP, respectively.
Conclusion: DIF on specimens exposed to formalin 10% in comparison to specimens exposed to normal saline is less sensitive but approximately as specific as it is in the diagnosis of pemphigus and BP patients and especially can be useful in pemphigus patients when only a formalin exposed samples is available.
