Journal of

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Background and Aim: Preoperative assessment of skin tumors extensions have a potential role to increase the efficiency of surgery and maximal preservation of function and cosmetics in the treatment of invasive types of basal cell carcinoma (BCC).
Methods: A total of 72 patients with BCCs on face were included in the study. Gross maximal width of tumors were documented, and then high frequency ultrasonic (HFUS) maximal width and depth of these lesions were determined. Then conventional surgical excision was done and these margins were determined in pathology lab. The comparison of ultrasonic and pathologic depth, and difference of HFUS and pathologic widths from gross clinical width were done with paired t-test.
Results: The mean depth of BCCs were 3.09 mm (SD= 1.02) in HFUS and 2.86 mm (SD=1.22) in pathology (P=0.1). The mean difference from gross width were 4.05 mm (SD=1.18) in HFUS and 4.26 mm (SD=1.70) in pathology (P=0.09).
Conclusions: High frequency sonography has a good accuracy in detection of width and depth of BCCs of face, especially in tumors smaller than 10 mm, and can help to determine safe margins non-invasively, especially in cosmetic and functional critical areas.

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Bacteria are natural sources of metabolites that exhibit diverse bioactive properties, including wound healing, antioxidative, antibacterial, antifungal, anti-inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria with wound healing potential are polysaccharides and peptides. In addition to cellulose, bacteria produce various polysaccharides (such as exopolysaccharides) with wound healing potential. The most common bacterial peptides used in wound healing studies are bacteriocins and lipopeptides. The aim of this article is to review recent literature on the potential of wound healing in vitro and in vivo by polysaccharides and peptides derived from bacteria (Actinobacteria, Bacteroides, Cyanobacteria, Firmicutes, and Proteobacteria). For this reason, a search was conducted in scientific research databases such as Web of Science, Google Scholar, Wiley, Elsevier, Taylor and Francis, BMC Springer and MDPI with the keywords polysaccharide, peptide, bacteriocins, lipopeptides, streptomyces, bacteria, lactic acid bacteria, cyanobacteria and wound healing. The overall results showed that polysaccharides and peptides and peptides derived from bacteria show wound healing power both in vitro and in vivo. In living models, including animals and humans, these metabolites have a positive effect on wound healing by inhibiting pathogens, antioxidant activity, modulating the inflammatory response, moisturizing the wound environment, promoting the proliferation and migration of fibroblasts and keratinocytes, increasing collagen synthesis, remodeling, epithelialization and angiogenesis. Therefore, peptides and polysaccharides derived from bacteria play a significant role in wound healing.

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Bacteria are natural sources of metabolites that exhibit diverse bioactive properties, including wound healing, antioxidative, antibacterial, antifungal, anti-inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria with wound healing potential are polysaccharides and peptides. In addition to cellulose, bacteria produce various polysaccharides (such as exopolysaccharides) with wound healing potential. The most common bacterial peptides used in wound healing studies are bacteriocins and lipopeptides. The aim of this article is to review recent literature on the potential of wound healing in vitro and in vivo by polysaccharides and peptides derived from bacteria (Actinobacteria, Bacteroides, Cyanobacteria, Firmicutes, and Proteobacteria). For this reason, a search was conducted in scientific research databases such as Web of Science, Google Scholar, Wiley, Elsevier, Taylor and Francis, BMC Springer and MDPI with the keywords polysaccharide, peptide, bacteriocins, lipopeptides, streptomyces, bacteria, lactic acid bacteria, cyanobacteria and wound healing. The overall results showed that polysaccharides and peptides and peptides derived from bacteria show wound healing power both in vitro and in vivo. In living models, including animals and humans, these metabolites have a positive effect on wound healing by inhibiting pathogens, antioxidant activity, modulating the inflammatory response, moisturizing the wound environment, promoting the proliferation and migration of fibroblasts and keratinocytes, increasing collagen synthesis, remodeling, epithelialization and angiogenesis. Therefore, peptides and polysaccharides derived from bacteria play a significant role in wound healing.