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Showing 3 results for Parham
Assessment of the relationship between psoriatic arthritis and nail involvement score (NAPSI) in psoriatic patients visiting Razi hospital dermatology clinic in 1386-87
Masoumeh Barzegari, Zahra Hallaji, Amirhoushang Ehsani, Pedram Nourmohammdpour, Maedeh Parham,
Volume 1, Issue 2 (6-2010)
Abstract

Background and Aim: Psoriasis is a chronic skin disorder involving many parts of the body including skin, nails and joints with severe negative effects on patient's quality of life. Nail involvement is one of the most difficult involvements of this disease to treat. Psoriatic arthritis categorized in sero-negative spondilo-arthropaties with some deforming characteristics. The aim of the present study was to evaluate the relationship between psoriatic arthritis and nail involvement based on standard psoriatic nail involvement score (NAPSI).
Methods: Psoriatic patients visiting dermatology clinic of Razi hospital were selected. Patients with arthritis enrolled as the case group while patients that had no joint involvement participated in control group. After matching, demographic data of both groups as well as NAPSI score and nail involvement characteristics collected through special questionnaires and analyzed with SPSS version 14.
Results: A total of 30 patients with psoriatic arthritis and 75 patients without arthritis were enrolled the study. Analysis of collected data demonstrated that nail involvement among patients with psoriatic arthritis (mean NAPSI score=46) was more common and severe than patients without joint involvement (mean NAPSI score=9.23) (P<0.05).
Conclusion: It seems that there is a significant difference between psoriatic patients presenting with or without arthritis and presence of arthritis probably can determine occurrence and extension of nail involvement.


A review of skin disorders in parkinson Disease
Parham Tamimi,
Volume 14, Issue 3 (Volume 14, No 3 2023)
Abstract
Parkinson Disease (PD) is a neurological disorder, which have comorbidity with some skin disorders. Skin disorders in Parkinson can be divided into two main groups including 1) non-iatrogenic disorders: melanoma, seborrheic dermatitis, sweating disorders, pemphigoid, rosacea, and 2) Iatrogenic disorders due to anti-Parkinson drugs side effects (like: carbidopa/levodopa, rotigotine, other dopamine agonists, COMT inhibitors and SC Apo morphine).
While seborrheic dermatitis is considered as a pre diagnostic sign, rosacea can be assumed as a warning sign of disease development. In addition, a strong correlation between PD and further bolus pemphigoid has been discovered. There might be a relation between melanoma and PD. It is important especially in patients with lighter skin with red and blond hair color. Hence, physicians should pay special attention in these patients and try to increase awareness in this population like reminding the importance of sun protection.
The role of incRNAs in pathogenesis, prognosis and treatment of non-melanoma skin cancer
Pegah Tamimi, Parham Tamimi, Aliasghar Ghaderi,
Volume 14, Issue 4 (Volume 14, No 4 2024)
Abstract
Dysregulation of long non-coding RNA may lead to various diseases including cancer. Recently, many lincRNAs have been discovered for their important roles in melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). These long non-coding RNAs are involved in skin cancer cell proliferation, angiogenesis, invasion, and metastasis.
Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.
Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.

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