Showing 26 results for Pedram
Amir Houshang Ehsani, Pedram Nourmohammadpour, Ataollah Moradi,
Volume 1, Issue 1 (3-2010)
Abstract
Tuberous sclerosis complex is a genetic disorder characterized by hamartoma formation in many organs. Its characteristic dermatologic manifestations include angiofibroma, shagreen patch, periungual fibroma and white macules. This disorder is usually accompanied by epilepsy and mental deficiency. Here, a 26-year-old man is presented who has been referred to a teaching hospital with a huge facial angiofibroma which had led to major psychological problems for him necessitating and appropriate treatment plan.
Amir Houshang Ehsani, Mostafa Mirshams Shahshahani, Zahra Hallaji, Pedram Noormohammadpour,
Volume 1, Issue 1 (3-2010)
Abstract
Background and aim: Actinic keratoses (AKs) are the third commonest complaint of patients visiting dermatologists. Topical treatment including 5-fluorouracil (5-FU) are among the commonest available therapies. According to local irritation induced by topical 5-FU The aim of current study was to compare efficacy of two different 5-FU based regimens with different application routes.
Methods: Patients with AKs confirmed by skin biopsy, matching our exlusion criteria were enrolled. Subjects randomized in two groups, receiving topical 5% 5-FU once daily or alternatedaily respectively. Two weeks after the end of one month period of the study, rate of reduction in number of lesions was documented by blinded academic dermatologists as well as treatment side effects.
Results: a total of 38 patients (23 male and 15 female) completed the study. Rate of side effects were lower in alternate-day applying patients (P<0.05) while rate of response to therapy were comparable in both groups (P>0.05).
Conclusion: alternate-day route for application of topical 5-FU is an acceptable alternative for classic daily application, to reduce rate of side effects and enhancing patients compliance.
Amirhoushang Ehsani, Pedram Nourmohammdpour, Shima Sayanjili,
Volume 1, Issue 2 (6-2010)
Abstract
Pulse Dye Laser (PDL) is mainly used to treat vascular lesions but several studies performed in different research centers have shown the efficacy of this safe laser in the treatment of non-vascular lesions as well. The aim of this study was to review, sum up and summarize these studies.PDL is a known alternative for cryotherapy in the treatment of some viral lesions such as periungual warts and molluscum contagiosum.The effect of this laser in the management of inflammatory lesions is not yet known and there have been controversial results. PDL has a very little effect on these dematoses and it is limited to the lesions with a clear vascular component, such as psoriasis and acne. Finally, regarding collagen remodeling and its usage in rejuvenation and in the treatment of hypertrophic scars, keloid and striae, the results from various studies are different and while they confirm its possible effect, more studies have to be conducted in order to determine appropriate treatment parameters.
Masoumeh Barzegari, Zahra Hallaji, Amirhoushang Ehsani, Pedram Nourmohammdpour, Maedeh Parham,
Volume 1, Issue 2 (6-2010)
Abstract
Background and Aim: Psoriasis is a chronic skin disorder involving many parts of the body including skin, nails and joints with severe negative effects on patient's quality of life. Nail involvement is one of the most difficult involvements of this disease to treat. Psoriatic arthritis categorized in sero-negative spondilo-arthropaties with some deforming characteristics. The aim of the present study was to evaluate the relationship between psoriatic arthritis and nail involvement based on standard psoriatic nail involvement score (NAPSI).
Methods: Psoriatic patients visiting dermatology clinic of Razi hospital were selected. Patients with arthritis enrolled as the case group while patients that had no joint involvement participated in control group. After matching, demographic data of both groups as well as NAPSI score and nail involvement characteristics collected through special questionnaires and analyzed with SPSS version 14.
Results: A total of 30 patients with psoriatic arthritis and 75 patients without arthritis were enrolled the study. Analysis of collected data demonstrated that nail involvement among patients with psoriatic arthritis (mean NAPSI score=46) was more common and severe than patients without joint involvement (mean NAPSI score=9.23) (P<0.05).
Conclusion: It seems that there is a significant difference between psoriatic patients presenting with or without arthritis and presence of arthritis probably can determine occurrence and extension of nail involvement.
Amirhoushang Ehsani, Pedram Nourmohammdpour, Shima Sayanjali,
Volume 1, Issue 3 (9-2010)
Abstract
Connective tissue nevi are types of hamartoma with increased collagen in which the amounts of elastin may vary. This report introduces an 18-year-old case with various nodular lesions in upper thigh area. Performed biopsy suggested the diagnosis of collagenoma which is a sub-type of connective tissue nevus.
Amiirhooshang Ehsani, Md, Pedram Noormohammadpour, Md, Asieh Shakib, Fatemeh Gholamali, Md,
Volume 4, Issue 2 (6-2013)
Abstract
Background and Aim: Xanthelasma is a benign condition considered which is mainly as a cosmetic problem. There are many destructive treatment options that may result in scar formation and dyspigmentation such as cryotherapy and electro-cauthery. According to these side effects finding a non-invasive solution could be important. At this study we aimed to evaluate the effect of PDL laser in the treatment xanthalasma.
Methods: Patients with bilateral palpebral xanthelasma having normal serum lipid profile were eligible for the study if they had no history of a collagen vascular disease or dermatologic disorders that were associated with Koebner phenomenon. All patients had two separate pulsed dye laser (PDL) treatment sessions, with a four-week gap in between and were photographed before every laser treatment session and four weeks after the second session. Visual analogue scale (VAS) scoring system was used to determine effect of treatment by two academic dermatologists blinded to the study as the referees. Mean healing score by the two referees considered as final score.
Results: Nine patients with a mean age (±standard deviation) of 38.0 (±9.2) years were included. All patients were female. The commonest site of lesions was upper lid, and final resolution score for all patients was less than 25%. There were no significant differences between viewpoints of the two referees. There were no major post operative complications. Patients followed for six months after the end of the treatment and there was no adverse effect.
Conclusion: The present study failed to demonstrate therapeutic efficacy of PDL in the treatment of xanthelasma. PDL with limited session numbers could not be considered as an alternative treatment for xanthelasma palpebrarum.
Fatemeh Vandrajabpour, Reza Raoofian, Fatemeh Gholamali, Pedram Noormohammadpour, Morteza Hashemzadeh Chaleshtori, Mina Tabrizi,
Volume 4, Issue 4 (12-2013)
Abstract
Basal cell carcinoma (BCC) is the most common cancer in Iran and in the world and its prevalence may become equivalent to the prevalence of all other cancers combined in the future. The Hedgehog (Hh) signaling pathway has an important role in tumorigenesis of BCC. Mutations in PTCH and Smo molecules of this pathway account for 85% to 95% of sporadic BCCs and also most cases of inherited cases. Currently, several treatment methods exist for this cancer. Mohs surgery and removing the whole tumor with free margins are the most efficient way for metastatic and highly invasive BCCs. According to the latest findings, small inhibitor molecules of the Hh pathway are becoming highlighted in drug production. Vismodegib an inhibitor of Smo, was approved by the Food and Drug Administration in 2012 as a drug for metastatic and highly invasive BCCs. Therefore, strategic targeting of signaling molecules has demonstrated success and holds great potential in medicine.
Pedram Noormohammadpour, Amirhooshang Ehsani, Mostafa Mirshams Shashahani, Fatemeh Shahmohammadi, Fatemeh Gholamali,
Volume 5, Issue 1 (Volume 5, Number 1 2014)
Abstract
Background and Aim: Malignant melanoma is one of the most lethal skin tumors. Its prevalence and demographic specifications are different in European and western countries from those in the Middle East. This study was aimed to evaluate the demographic and clinical characteristics of malignant melanoma in Iran.
Methods: In this cross-sectional study, the patients with the diagnosis of malignant melanoma who atteneded the tumor clinic of Razi Hospital, Tehran, Iran were included. Demographic and clinical data were registered in specific questionnaires. Histopathology findings were also recorded in the questionnaires.
Results: A total of 2500 patients attending tumor clinic of Razi Hospital were evaluated. Out of them, 166 cases had malignant melanoma including 89 (53.6%) females and 77 males (46.4%). The mean age of patients 60.5 years. History of chronic sun exposure was found in 65 (39.2%) cases. Mean delay time between commencement of lesion and diagnosis was 9 months. The most common histopathologic type was acral lentiginous and the most common observed stage of tumor was Clark 3. The most common frequent observed tumor site was head and neck which was followed by limbs.
Conclusion: Malignant melanoma is common in patients with skin tumors in Iran. Considering morbidity and mortality of malignant melanoma and the relatively high stages of tumors, at the fist time the patients sought medical care, screening programs seems to be necessary to find the patients in earlier stages, as well as the mass education. Some of our findings such as the most common location of the tumors, family history and relation with dysplastic naevies, remain to be confirmed in studies with larger sample sizes.
Pedram Nourmohammadpour, Amir Houshang Ehsani, Kambiz Kamyab, Bita Saghi, Hassan Seirafi, Ali Sadeghinia, Fatemeh Gholamali,
Volume 5, Issue 2 (Volume 5, Number 2 2014)
Abstract
Background and Aim: Due to new popularity of cosmetic tattoos especially among women and its potential relationship with sarcoidosis, the present study was conducted to evaluate clinical presentation and some demographic data about tattoo granuloma, as part of non-infectious dermatologic granulomas.
Methods: In this retrospective cross-sectional study, all patients with the histopathological diagnosis of non-infectious granulomatous lesions whom were admitted between at the dermatology clinics at Razi Hospital, Tehran, Iran between March 21, 2007 and March 20, 2012 were included.
Results: A total of 1099 patients were included in the study. The commonest form of granuloma was foreign body granuloma in 511 (46.4%) of the patients and was followed by tattoo granuloma in 102 (9.2%) of the patients. All patients with tattoo granuloma were females whose ages were from 40 to 60 years. The mean±standard deviation age of the patients was 43±8.57 years. Twenty-six (25%) of patients with tattoo granuloma showed sarcoidal pattern, and one case (1%) showed caseouse pattern, after histopathological evaluation of biopsy specimens. Majority of the lesions were papular (32.3%) followed by nodular (24.5%) lesions.
Conclusion: Tattoo granuloma is the second common form of non-infectious granulomas, and in one-quarter of cases has sarcoidal pattern. Considering this finding, it seems reasonable to evaluate these patients for sarcoidosis.
Hamidreza Ghasemi Basir, Mahmood Farshchian, Pedram Alirezaei, Mahdis Jahani,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
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Background and Aim: Cicatricial
alopecia is the result of irreversible substitution of hair follicles with
fibrotic tissue and presents as permanent loss of hair. Only a few studies
have investigated the clinical and histopathological characteristics of
cicatricial alopecia in Iran. The aim of this study was to determine the
demographic, clinical and histopathological characteristics of patients with
cicatricial alopecia who referred to our dermatology outpatient clinic in
Farshchian hospital in a two year period, and to evaluate the diagnostic
value of histopathologic criteria in diagnosing different kinds of
cicatricial alopecias.
Methods: This was a
cross-sectional study. Eighty nine patients who underwent skin biopsy due to
clinical diagnosis of cicatricial alopecia were included. Demographic and
clinical characteristics of patients as well as clinical diagnosis were
recorded and the biopsy samples were evaluated by two different pathologists
who were unaware of each other's diagnosis. Histopathological diagnosis of
patients according to each pathologist's opinion was recorded separately and
statistical analysis was performed to obtain the coincidence coefficient between
two pathological diagnosis.
Results: The most common
forms of cicatricial alopecias due to clinical and histopathological
diagnosis were: lichen planopilaris, disciod
lupus erythematosus, alopecia
areata, pseudopelade
of Brocq, folliculitis
decalvans and
central centrifugal cicatricial alopecia. Moreover,
our findings showed a powerful coincidence coefficient between clinical
diagnosis and the first pathologist diagnosis (kappa=0.836), an average to
powerful coincidence coefficient between the second pathologist diagnosis and
clinical diagnosis
(kappa=0.703) and finally an average to powerful coincidence coefficient
between the two pathologists diagnosis
(kappa=0.663).
Conclusion: Diagnosis of
cicatricial alopecia depends upon clinical and also histopathological
examination. Diagnostic value of histopathological criteria even at the end
of scarring process when there is considerable overlap between microscopic
findings of different etiologies of cicatricial alopecias is still acceptable
and there is no need to re-evaluate the biopsy specimen by a second
pathologist in order to confirm the diagnosis.
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Zahra Hallaji, Alireza Khatami, Reza Robati, Hassan Seirafi, Alireza Firooz, Vahideh Lajevardi, Zoherh Mozafari, Parvin Mansouri, Pedram Mehryan, Mansour Nassiri-Kashani,
Volume 6, Issue 1 (Volume 6, Number 1 2015)
Abstract
Urticaria is a common and challenging skin disorder. Its diagnosis and treatment is not limited to the field of dermatology. General physicians, and allergologists and clinical immunologists are also commonly involved in the management of urticaria patients.
One of the missions of the Iranian Society of Dermatology is to develop strategies to provide the best possible management for patients suffering dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Amir Houshang Ehsani, Hossein Mortazavi, Pedram Noormohammadpour, Arghavan Azizpour, Sara Rostami, Maryam Nasimi,
Volume 7, Issue 2 (Volume 7, Number 2 2016)
Abstract
Background and Aim: Acne vulgaris is a common skin disorder. This study was conducted to evaluate the impact of Ramadan fasting on acne healing in patients admitted to the dermatology clinic, Razi Hospital, Tehran.
Methods: In this prospective cohort study, 10 fasting persons (9 women and 1 man) and 10 non-fasting persons (9 women and 1 man) with acne were studied. Their baseline acne severities were recorded and acne improvement was evaluated in both groups after Ramadan month.
Results: Acne improvement was 71% in fasting persons and 49% in non-fasting persons. Improvement in fasting persons i.e. was 1.4 times of non-fasting ones (P=0.158). However, no significant statistical difference was detected. Also, it was determined that improvement was different according to acne grading. Improvement in acne lesions in patients with grade 2 severity was 100%, in those with grade 3 acne was 78%, and in patients with grade 4 acne was 35 % (P=0.025). But in non-fasting patients there was not a statistical difference between acne severity and improvement rate. Furthermore in patients younger than 24, improvement rate of acne was 1.6 fold more than non-fasting persons and in patients older than 24, this ratio was 1.3 (P=0.011).
Conclusion: This study did not show any statistically significant difference in acne improvement between who were fasting and who were not during Ramadan. Studies with larger sample size are recommended.
Amir Hooshang Ehsani, Maryam Nasimi, Pedram Noormohammadpoor, Arghavan Azizpoor, Fatemeh Golpayegani,
Volume 8, Issue 1 (Volume 8, Number 1 2017)
Abstract
Background and Aim: The aim of this study was to evaluate surgery approach outcomes in patients with squamous cell carcinoma (SCC) of lower lip.
Methods: We retrospectively analyzed medical records of patients that diagnosed with SCC of the lower lip at Razi hospital at Tehran University of Medical Sciences in a 5 year period. Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher’s exact tests to compare the variables.
Results: The age range of patients was 35 to 94 years (mean, 64.1 years; SD, 13.27 years), with a 5:1 male-female ratio. SCC of the lower lip occurred more frequently in patients older than 60 years. 62.1 % of the patients were addicted to cigarette and other tobacco compounds. It was noted
significant association between chronic solar exposure in the job’s environment and incidence of SCC in lower lip. Mean diameter of the tumor was 28.1 mm (range, 5 to 63 mm). Recurrence was detected in 17 patients (24.6%). Two patients (2.89%) died due to lower lip SCC in this series.
Conclusion: our study revealed that lower lip SCC is more prevalent in men and in eighth decade of life. As well, considering the low recurrence rate and high survival rate, surgery could be considered as an effective method of treatment.
Pedram Alirezaei, Zeinab Memarzadeh, Sara Molkara, Seyedeh Fatemeh Yaghoubi Al,
Volume 10, Issue 1 (2019, Volume 10, Number 1 2019)
Abstract
Background and Aim: Seborrhoic dermatitis is one of the most common diseases in dermatology with a prevalence of about 2%. Many treatments have been used for this disease. This Study aimed to investigate the efficacy of betamethasone lotion compared with clotrizone lotion in patients with seborrheic dermatitis of face and scalp.
Methods: This double blind study was performed on 60 patients with seborrheic dermatitis older than 18 years, who refered to Emam Reza hospital, Mashhad. Patients were divided into two groups: clotrizone (31) and betamethasone group (29 patients). Patients were treated for a month. We evaluated severity of pruritus, erythema and desquamation of the face and scalp.
Results: The average age of patients participating in the study was 33.1 years (18 to 56 years) and 56.7% of patients were male. No significant differences were found in age and gender between the two groups (P> 0.05). Both treatments reduced severity of erythema and desquamation of the face and scalp (P<0.001). Two weeks after treatment, clotrizone had better performance, but there after both lotions had similar effect. Betamethasone reduced pruritus more than clotrizone.
Conclusion: This study showed that both betamethasone and clotrizone were effective. Clotrizone has better impact on the severity of erythema and scaling and betamethasone has better effect on improving the severity of pruritus.
Delara Amirdastmalchi, Amirhooshang Ehsani, Maryam Nasimi, Vahideh Lajvardi, Pedram Noormohamadpoor,
Volume 11, Issue 1 (Volume 11, No 1 2020)
Abstract
COVID-19 was announced pandemic by March 2020. Due to the high prevalence of the disease and its staggering spread, it is very important to identify various manifestations of this viral infection.
The aim of this study is to review published articles about cutaneous involvement of COVID-19 disease.
Cutaneous manifestations are rare in COVID-19 disease and it is essential to recognize these possible skin manifestations in order to detect and treat COVID-19 disease and to prevent further transmission.
Farasat Noormohammadifar, Alireza Soltanian, Pedram Alirezaei,
Volume 11, Issue 3 (Volume 11, No 3 2020)
Abstract
Background and Aim: Trichoscopy is a non-invasive diagnostic tool for hair diseases. The aim of this study was to evaluate the trichoscopic findings in different types of alopecia.
Methods: This cross-sectional study was conducted on 155 alopecia patients referring to Hamadan’s Sina hospital from March 2019 to July 2020. The patients were recruited after giving written informed consent. Scalp biopsy was performed to confirm the diagnosis and trichoscopic evaluation was then carried out. Trichoscopic findings along with demographic data were recorded. Data was analyzed using SPSS 16.0 software and appropriate statistical methods.
Results: A total of 155 patients including 79 males and 76 females were included in the study. The most common trichoscopic finding in alopecia areata was vellus hair (95.5%). The most common finding in androgenetic alopecia (AGA) was hair shaft thickness heterogeneity which was observed in all AGA patients. The most common findings in telogen effluvium (TE) were single hair pilosebaceous units, peripilar sign, thin terminal hairs and upright regrowing hairs which were observed in all TE patients. The most common finding in lichen planopilaris was perifollicular scaling (81.8%). The most common findings in discoid lupus erythematosus were large yellow dots (100%) and fine scaling (100%). Black dot was the most prevalent finding in tinea capitis (85.7%).
Conclusion: Trichoscopy ,as a non-invasive tool, could be helpful in differentiating different types of alopecia.
Sina Khanali, Alirezaei Pedram , Jalal Poorolajal,
Volume 11, Issue 4 (Volume 11, No4 2021)
Abstract
Background and Aim: Atrophic scars constitute a common complication of acne and various methods have been proposed for their treatment. This study aims at comparing the efficacy of fractional CO2 laser with microneedling in the management of atrophic acne scars.
Methods: Patients with atrophic acne scars presenting to dermatology clinic of Hamadan’s Sina hospital between March 2016 and March 2018 were included in the study. Every 3 weeks, each patient received fractional CO2 laser on one side of the face and microneedling on the other side, for a total of 4 sessions. Patient’s satisfaction and the severity of scars (based on Goodman and Baron’s scar scale) were assessed 1, 2 and 6 months thereafter.
Results: Overall, 24 participants were included. Prior to intervention, no significant difference was observed between groups in terms of mean scar score (P=0.726). At 1, 2 and 6month follow-up visits, the scar score of the side treated with laser was significantly lower than the microneedling side (P for 1, 2 and 6month follow-up visits: 0.033, 0.008 and 0.014). No significant difference was observed between groups in terms of patient’s satisfaction (P for 1, 2 and 6 month follow-up visits: 0.589, 0.469 and 0.840). The most prevalent side effect was erythema in 3 patients treated with laser. Due to low prevalence, statistical analysis of side effects between groups was impossible.
Conclusion: Compared to microneedling, fractional CO
2 laser was more effective in reducing the scar score of patients. The prevalence of side effects in both treatments were low.
Mohamad Ahmadpanah, Amir Amini, Zahra Cheraghi, Pedram Alirezaei,
Volume 12, Issue 1 (Volume 12, No 1 2021)
Abstract
Background and Aim: Acne vulgaris is one of the most common skin disorders, affecting more than eighty percent of individuals around puberty. Because of the adverse effects on the patient’s appearance, the disease may have detrimental psychological impacts such as low self-esteem and social isolation. The aim of the present study was to evaluate factors affecting self-esteem in patients with acne vulgaris in Hamadan.
Methods: Patients with acne vulgaris referred to the dermatology clinic of Hamadan’s Sina Hospital (as the case group), and their healthy accompanying persons (as the control group) were included in the study. After obtaining written informed consent, demographic dat
a were recorded and participants were asked to fill out a questionnaire. To assess the severity of acne, Global Acne Grading System (GAGS) was used. In addition, Coopersmith Inventory was applied to measure the self-esteem of the participants. In data were analyzed using STATA 14.0 software.
Results: Overall, 184 patients with acne and 177 controls were included in this study. The mean age of patients and controls was 17.89+3.13 and 17.72+2.94, respectively. Independent samples t-test showed that the mean Self-Esteem Index of patients was significantly lower than controls (32.04+8.29 vs. 34.85+7.73, P<0.001). The severity of acne was inversely correlated with self-esteem; one score increase in GAGS would result in 0.1 unit decrease in self-esteem index (P<0.001).
Conclusion: Acne vulgaris is associated with low self-esteem and the severity of acne is inversely correlated with self-esteem level.
Pedram Noormohammadpour, Amirhooshang Ehsani, Ifa Etesami, Amin Rahmani,
Volume 13, Issue 1 (Volume 13, No 1 2022)
Abstract
Background and Aim: Skin injuries with various causes may lead to legal action. Complaints are referred to specialized authorities such as Razi Hospital, before specialized forensic medicine commission comment. The present study surveyed demography of patients' complaints and initial diagnosis at the time of referral over a period of 6 months.
Methods: In this retrospective study, patients referred for initial visit, from Forensic Medicine Office in the September 2018-March 2019, were examined. The patients' complaints at the time of referral and the clinical diagnosis made at the initial examination were recorded.
Results: A total of 220 patients including 176 women (80%) and 44 men (20%) with a mean age of 34.8 years were included. 42 different complaints were documented, including traumatic hair loss with 91 cases (41.4%) - the most common - followed by complications of laser hair removal with 32 cases (14.6%) and filler injections with 16 cases (7.3%). Scarring from trauma, reaction to chemicals during work or accidental contact, rare injuries from various treatments, and even cases of pediculosis (contamination of the accommodation) or zoster (complaint about care in the treatment center), etc. were observed.
Conclusion: Traumatic hair loss (mainly due to fight) was the most common complaint. Knowing other cases may expand physicians' awareness regarding the wide range of complaints that can be raised and improve the process of some treatment measures.
Pedram Noormohammadpour,
Volume 13, Issue 1 (Volume 13, No 1 2022)
Abstract
Portwine stains (PWS) lesions are one of the most common childhood vascular malformations that gradually increase in color and thickness without treatment and have profound devastating psychological effects on the child. For this reason, and also because the lesions become resistant to treatment over time, early treatment of these lesions is very important. pulsed dye laser (PDL) is currently the treatment of choice for these lesions. In almost all aspects of the treatment of these lesions with PDL laser, disagreement and sometimes contradictory data are found among various studies. These include the uncertainty of the optimal number of treatment sessions, the appropriate age to start treatment, the optimal parameters to start treatment with and possible methods to increase the effectiveness of PDL, possible treatment side effects and how to deal with them, as well as using different methods to reduce patient discomfort during treatment. The present article collects and reviews existing studies in this field.
