Showing 5 results for Sadr
Zahra Delavarian, Nooshin Mohtasham, Abbas Javadzadeh Bolouri, Shahab Babakoohi, Bardia Sadr, Mohammad Taghi Shakeri, Kambiz Kamyab-Hesari, Farnaz Bidram,
Volume 1, Issue 1 (3-2010)
Abstract
Background and aim: Oral lichen planus, is a chronic inflammatory mucocutanous lesion which is defined as a premalignant lesion. Matrix metaloprotenase 2 (MMP-2) and MMP-9 are protenases which facilitates invasion of tumoral cells to connective tissue and are over-expressed in premalignant and malignant lesions. The aim of this study was to determine the expression of MMP-2 in erosive and non-erosive oral lichen planus and inflammatory hyperplasia by immunohistochemistry.
Methods: in this cross sectional study 39 specimens of non-erosive oral lichen planus (with and without dysplasia), 36 specimens of erosive ones (11 dysplastic and 25 non-dysplastic, 32 inflammatory hyperplasias and 6 samples of normal oral mucosa were chosen form pathology archive of Faculty of Dentistry, Mashhad university of Medical Sciences and were stained immunohistochemically by MMP-2 and MMP-9 markers. Kruskal-Wallis, Mann-Whitney and Spearman correlation coefficient were used.
Results: The highest mean expression of MMP-2 and MMP-9 (in all layers) were observed in erosive oral lichen planus (68.18±31.62 and 94.5±3.5, respectively). MMP-9 expression in erosive oral lichen planus in comparison to non-erosive one showed significant difference in all layers (P<0.001) and the expression of MMP-2 showed a significant difference in basal –para basal and prickle layers (respectively: P=0.008, P<0.001).
Conclusion: the linear increase seen in the expression of markers from normal mucosa to erosive oral lichen planus indicates the difference of biological behavior between erosive and non-erosive oral lichen planus. Hence, it is concluded that erosive oral lichen planus is of the higher premalignan potential compared with its non-erosive correspondent.
Bardia Sadr, Shahab Babakoohi, Ferial Fanian, Maryam Sarraf-Yazdy, Ali Kazerouni-Timsar, Mansour Nassiri-Kashani, Yahya Dowlati, Alireza Firooz,
Volume 1, Issue 2 (6-2010)
Abstract
Background and Aim: several studies have been conducted to evaluate skin pH in various diseases, but there are few reports in normal population. The aim of this study was to evaluate skin pH in healthy individuals.
Methods: Fifty healthy volunteers were enrolled in this study. The subjects were divided by age into 5 groups, i.e., 10-20, 21-30, 31-40, 41-50 and 51-60 years old. In each group, 5 females and 5 males were examined. A pH meter (Courage & Khazaka electronic GmbH, Germany) was used to measure pH in 8 different locations of the body (forehead, cheek, nasolabial fold, neck, forearm, dorsal side of hand, palm and leg).
Results: The mean values for pH in these locations were 5.25, 5.15, 5.06, 4.90, 4.75, 4.80, 4.69, and 4.83 respectively. pH was significantly higher in women (P<0.001). There was a significant difference between skin pH in different age groups (P=0.002). The highest and lowest amounts of pH belonged to the forehead (5.26 ± 0.68) and leg (4.69 ± 0.40), respectively.
Conclusion: Age and sex and location have remarkable effects on skin pH.
Morteza Akbari, Anis Askari Zadeh, Kayvan Sadri, Mehrdad Iranshahi, Mahmoud Reza Jaafari, Ali Khamesipour, Ali Badiee,
Volume 8, Issue 4 (Volume 8, Number 4 2018)
Abstract
Background and Aim: Curcumin possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. The aim of this study was to develop liposomal formulation of curcumin and evaluate the leishmanial effects of its topical use against L. major in vitro and in vivo.
Methods: Nanoliposomes containing 1, 2 or 3% curumin were prepared by fusion method and characterized for their size, morphology and stability. The in vitro efficacy of liposomal form of Curcumin against promastigotes and amastigotes form of L. major was also evaluated. Moreover, the leishmanial effect of formulations was evaluated in infected BALB/c mice. The lesions were treated topically by different formulations twice a day, for 4 weeks. During this time and 4 weeks after treatment, lesions size was measured every week. The level of splenic parasite burdens was investigated in week 4 after parasite inoculation.
Results: Curcumin showed no leishmanicidal effect against live promasigotes and amastigotes in culture media. There was no significant difference between treated and control animals regarding lesion size and splenic parasite burden.
Conclusion: The results of this study showed that nanoliposomes containing curcumin in topical form has no significant leishmanicidal effect in vitro and in vivo against
L. major.
Hamideh Herizchi Qadim, Asal Sadri,
Volume 9, Issue 4 (2018, Volume 9, Number 4 2019)
Abstract
Introduction:Herpes zoster is a common disease in adultsthat appear upon Reactivation of latent VZV in dorsal rootgangelion cells.
Case Report: A patient was a7 month old boy with vesicularlesions in one dermatom. He has history of varisella,2 monthago.
Conclusion:Also varisella zoster is rare in children but ifdermatomal vesicular lesionswas seen in child we shouldconsider this diagnosed.
Zahrabeigom Moosavi, Alireza Firooz, Sara Sadrzadeh,
Volume 11, Issue 4 (Volume 11, No4 2021)
Abstract
The fourth paper of review article series about COVID-19 includes a selection of interesting and useful information about this disease and dermatology. This paper contains materials published in literature in various basic fields such as epidemiology, pathogenesis, as well as clinical topics such as symptoms and treatments. The skin manifestations of COVID-19, the challenges of treating skin diseases and dermatoses caused by the virus have also been reviewed.
