Showing 6 results for Shamsi Meymandi
Soodabeh Zandi, Simin Shamsi Meymandi, Sadegh Hasheminasab Gorji, Fatemeh Sabouri Shahrebabak,
Volume 2, Issue 3 (9-2011)
Abstract
Background and Aim: Psoriasis is a chronic, relapsing disease of the skin with psychological and somatic impacts that leads to substantial effects on the quality of life. The aim of this study was to determine the quality of life in psoriatic patients.
Methods: This cross-sectional study was conducted on 97 psoriatic patients in dermatology and PUVA clinic in Afzalipour hospital in Kerman from March 2009 to March 2010. Quality of life and disease severity were Dermatology Life Quality Index (DLQI) and Psoriasis Area Severity Index (PASI). Data analysis was done through conducting, chi-square and one-way AVONA tests and P<0.05 was considered as significant.
Results: 55.7% of patients were male and mean age of them was 35.3 years (range: 16-75 years). Psoriasis vulgaris was the most common type (76.3%), and arthropathy was seen in 3.1% of patients. The mean duration of the disease was 21 months (range: 11 months-30 years).The mean of DLQI score was 14.1(range: 1-29) and mean PASI score was 18.6 (range: 0.6-66.6). DLOI score correlated with severity of disease (PASI), marital status, and type of the disease (P<0.05).
Conclusion: Psoriasis has a severe negative impact on the quality of life of the patients. Therefore, supportive social and spiritual efforts are necessary to decrease these effects.
Simin Shamsi Meymandi, Vaseli Mohammad Bagher, Farzad Abroud,
Volume 5, Issue 1 (Volume 5, Number 1 2014)
Abstract
Background and Aim: Common wart is a viral infection of epithelial tissues caused by human papiloma virus (HPV). In order to increase the efficacy and concurrent reduction of complications, different types of combination therapies have been recommended. One of them is the combination of cryotherapy with cantharidin. As cantharidin causes little pain and leaves small scars, we decided to design and conduct a randomized, controlled trial to investigate the efficacy of combined cryotherapy and topical cantharidin versus cryotherapy and a topical placebo. The mean number of the treatment sessions and complications of treatments were also compared between the two groups.
Methods: This study was a randomized, controlled double blind clinical trial in which 110 patients with verruca vulgaris were randomly allocated into two groups. After cryotherapy in both groups, topical lotion of cantharidin 0.7% (Canthacur) and flexible collodion as placebo were applied topically in the intervention and control groups, respectively. Patients were followed for healing rates, complications and recurrence of the lesions.
Results: The healing rates of lesions in both groups were 100%. The mean number of treatment sessions in the intervention and control groups were 3.4 and 4.7, respectively
(P<0.001). The incidence of hyperpigmentation in the intervention and control group were 29.1% and 10.9%, respectively (P=0.017). Atrophic scars in the case group were less common than the control group (9.1% versus 29.1%). Within 4 weeks of follow up after completion of the treatment protocol, the frequency of other complications and recurrence of the lesions showed no statistically significant difference between the two groups.
Conclusions: Combination of cryotherapy and cantharidin reduced the number of treatment sessions and atrophic scars, but increased the hyperpigmentation. Also, this combination therapy was ineffective in reducing other complications and the recurrence rate of the lesions.
Simin Shamsi Meymandi, Rezvan Amiri, Maryam Aflatunian, Abas Pardakhti,
Volume 5, Issue 2 (Volume 5, Number 2 2014)
Abstract
Background and Aim: Androgenetic alopecia (AGA) is the most common type of alopecia in men. Currently, minoxidil is the only topical drug which has been approved by FDA for the treatment of AGA. However, its efficacy is restricted because of its low skin penetration. Since vesicular systems such as liposomes and niosomes have higher efficacy and lower adverse effects, this study was conducted to compare the efficacy of topical niosomal minoxidil with conventional minoxidil in the treatment of AGA.
Methods: This study was a randomized, controlled double-blind clinical trial. Ninety male patients with AGA according to Hamilton criteria were enrolled into this trial. The participants applied the interversion to which they were allocated twice a day, and were evaluated monthly for 6 months by a physician and patients self-assessments.
Results: Eighty-eight patients completed the trial. Mean increased hair count in niosomal minoxidil group and conventional minoxidil group in the last visit were 28.18±11.00 and 14.22±5.23, respectively (P<0.001). Moreover, evaluation of treatment response according to the patients self-assessments were 8.72±5.03 and 3.33±2.67 in niosomal and conventional minoxidil, respectively, which revealed more satisfaction in niosomal group (P=0.001). With the exception of two cases in niosomal minoxidil group whom were withdraw due to scalp itching and erthema no other adverse effect was observed in either group.
Conclusion: In the present study, application of topical niosomal minoxidil revealed an increase in the hair count in comparison with conventional minoxidil solution. Application of this new formulation for the treatment of AGA may be recommended.
Simin Shamsi Meymandi, Siavash Mohammadzadeh Shanehsaz, Mehdi Ansari Dogaheh, Yunes Jahani,
Volume 7, Issue 1 (Volume 7, Number 1 2016)
Abstract
Background and Aim: Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The goal of this study was to evaluate the efficacy of a cream containing 4% licorice extract with a novel formulation based on solid lipid nanoparticles technology in the treatment of melasma. To the best of our knowledge, it is the first study designed to investigate the efficacy of this novel formulation in the treatment of melasma all over the world.
Methods: In this randomized, double-blind, placebo-controlled clinical trial, 44 women with clinical diagnosis of melasma referred to the Afzalipour hospital dermatology clinic were randomly allocated into two treatment groups of equal size. All the patients were interviewed and examined every four weeks during the trial and their Modified Melasma Area and Severity Index (MMASI) score were evaluated at 4, 8 and 12 weeks. The efficacy of the interventions were classified in four levels: complete response, significant response, partial response and no response.
Results: Forty patients were enrolled in the study. At the end of the study (12 weeks), mean± standard deviation of MMASI score changed from 11.03±2.7 to 1.41±0.6 in the intervention group and from 11.25±2.9 to 2.37±1.2 in the placebo group, respectively (P<0.001).
Conclusion: Licorice extract can be used as a skin-lightening agent with minimal side effect in the treatment of melasma. Nano/micro solid lipid particles are used as carriers with unique properties like size, surface electrical bar. Moreover, a large amount of the drug might be loaded to increase the efficacy and decrease the adverse events.
Saman Mohammadi, Payam Khazaeli, Simin Shamsi Meymandi, Mahin Aflatoonian, Maryam Khalili Meybodi, Niloofar Mehrolhasani, Azadeh Mohebi, Yuns Jahani,
Volume 7, Issue 2 (Volume 7, Number 2 2016)
Abstract
Background and Aim: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Retinoids are used as the first line therapy in acne. Systemic absorption and skin irritation including redness, pruritus and exfoliation are some of their side effects. In this study we compared the efficacy of isotretinoin 0.05% niosomal gel versus adapalen 0.1% gel in treatment of acne vulgaris.
Methods: In this randomized double blind clinical trial, 144 patients with mild to moderate acne vulgaris aged from 15 to 30 years were enrolled. The patients were randomly allocated into two groups of A, whom were treated with isotretinoin 0.05% niosomal gel and B whom were treated with adapalen 0.1% gel. The patients were evaluated for clinical reponse, decrease in the number of inflammatory and non-inflammatory lesions and side effects after 2, 4, 8, and 12 weeks of the initiation of treatment.
Results: At the end of the study the clinical responses of comedones and inflammatory lesions in isotretinoin 0.05% niosomal gel group were 68% and 79%, in comparison with 65% and 76% in the adapalen gel group, respectively. The differences were not statistically significant. At the end of the treatment period more decrease in number of inflammatory and non-inflammatory lesions were seen in group A patients (niosomal isotretinoin) than group B (adapalen 0.1% gel) (P<0.001). Also side effect of skin redness was found more in group B (P<0.001).
Conclusion: Isotretinoin 0.05% niosomal gel has less side effects and more efficacy in the treatment of mild to moderate acne vulgaris in comparison with adapalen 0.1% gel.
Maryam Khalili, Mahin Aflatoonian, Shima Bahrami, Simin Shamsi Meymandi,
Volume 7, Issue 2 (Volume 7, Number 2 2016)
Abstract
Background and Aim: Lichenoid tissue reactions are a group of skin diseases with hydropic degeneration of the basal cell layer and inflammatory infiltrations in papillary dermis. The aim of this study was to investigate the clinicopathological features of skin diseases with lichenoid tissue reaction.
Methods: This retrospective cross-sectional study was conducted on 118 cases with lichenoid tissue reactions. Pathological and clinical features such as age, sex, location of the lesions were evaluated.
Results: 53.4% of the patients were female. Mean age of the patients was 39.9±17.37 years. Mean duration of the disease was 21.82±14.3 months. The most common site of involvement was upper limb (24%). The most frequent histopathological findings in epidermis and dermis were hydropic degeneration of the basal cell layer and papillary lymphocytic infiltration (89.9%, 85.5%, respectively). Lymphocytes were the most frequent inflammatory cells in dermis. Colloid bodies and melanin incontinency also were seen in 60.2% and 78% of cases, respectively.
Conclusion: Pathological evaluation can be helpful in differentiating skin disease with lichenoid tissue reactions, if there is a doubt in clinical diagnosis.
