Showing 6 results for Soori
Vahide Lajevardi, Md, Fatemeh Gholamali, Md, Kambiz Kamyab, Md, Maede Rayati Damavandi, Md, Tahereh Soori, Md, Azadeh Goodarzi, Md, Zeinab Aryanian, Md,
Volume 4, Issue 2 (6-2013)
Abstract
Ichthyosis is defined as a group of diseases with keratinization disorder and diffuse scaling with highly variable degree of involvement. According to our knowledge, coincidence of ichthyosis and dermatophytosis, which both are very common disorders, is a very rare event. We report a young man with congenital ichthyosis that histological analysis of his skin biopsies and direct smear revealed PAS positive fungi. He had used topical steroids for generalized scaling erythematous patches and plaques for long time.
Tahereh Soori, Nafiseh Esmaeili, Mostafa Mirshams-Shahshahani, Mohammad Reza Poursadati, Abbas Karimi,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract
Background
and Aim: The standard treatment regimen for pemphigus is
adminitration of systemic corticosteroids and adjuvant agents. Previous studies
have shown that corticosteroid therapy may alter lipid profile and reduce the
atherogenic index in some disorders. This study was conducted to evaluate
the changes in lipid profile in pemphigus patients treated with oral
corticosteroids alone or in combination with adjuvants.
Methods:
In this retrospective corss-sectional study, medical records of 148 pemphigus
patients admitted in Razi Hospital in Tehran were reviewed for serum levels of
low-density lipoprotein (LDL), high-density lipoprotein (HDL), total
cholestrol, and triglyceride on the day of admission till 3 weeks after
initiation of the treatment.
Results:
Fifty-eight percent of patients were female and the mean age of the patients
was 47.1 years. 79.3% and 13.3% of patients had been treated with prednisolone
plus azathiorine or prednisolone alone, respectively. The remainig patients
were treated by administration of oral prednisolone and other adjuvants. Serum
levels of LDL, HDL, total cholestrol and triglyceride were significantly higher
3 weeks after initiation of treatment compared to baseline (P<0.05). With
the exception of the signifcantly higher level of triglycerides in women, there
was no statistically significant association between the levels of other serum
lipids at the end of 3 weeks treatment with gender, age, severity of the
disease, use of statins, and the treatment regimen (P>0.05).
Conclusion:
Although the level of different components of the lipid profile in Iranian
patients with pemphigus changed after receiving treatment for 3 weeks, it seems
that those changes were not associated with an increased atherogenic index of
pemphigus patients.
Freshteh Osmani, Ebrahim Hajizadeh, Parvin Mansoori,
Volume 6, Issue 1 (Volume 6, Number 1 2015)
Abstract
Background and Aim: Psoriasis is an inflammatory skin disease, which is related to the immune system and is characterized by the rapid growth of skin cells. The aim of this study was to investigate some risk factors in psoriasis and also to check that whether the rate of recurrence is fixed or variable in different seasons by using a time-dependent coefficients rate model.
Methods: After reviewing the files of psoriasis patients that had been hospitalized in March 2011 to March 2014 in the dermatology ward of Imam Khomeini Hospital in Tehran, a total of 160 patients who had relapses leading to hospitalization, entered to the study. A rate model with time dependent coefficients by using R software version 3.1 was fitted and risk factors for recurrence were identified. Effect of the season on the recurrence of psoriasis was evaluated.
Results: Recurrence rate of psoriasis was 7.2 times higher in winters than in springs, which had the lowest recurrence rate. Spring and summer were associoated with lower recurrence rates. Effect of season on the relapse of the disease was significantly different for different seasons (P<0.01). Also, infection, stress, positive family history, hypocalemia, the normal number of white blood cells and temperature changes were associated with psoriasis relapse (P<0.05).
Conclusion: Recurrence rate of psoriasis is different in different seasons. Psoriasis recurrence rate was 7 times higher in winters in comparison with springs.
Nafiseh Esmaeili, Tahereh Soori, Zeinab Nooraei, Abbas Karimi,
Volume 6, Issue 2 (Volume 6, Number 2 2015)
Abstract
Background and Aim: Pemphigus vulgaris is a rare autoimmune intraepidermal blistering disease affecting the skin and mucous membranes. Copper and zinc are two necessary trace elements in the human body that have antioxidant activity in the wound healing process. The aim of this study was to determine the serumic level of zinc and copper in newly diagnosed patients with pemphigus vulgaris.
Methods: In this study, 50 newly diagnosed patients with pemphigus vulgaris admitted to Razi Hospital in Tehran were studied with regards to their serum levels of copper and zinc alongside age, sex, body mass index (BMI), smoking and drug abuse status.
Results: Eighteen percent (9 cases) and 50% (25 cases) of the patients showed copper and zinc deficiency, respectively. There was no significant association between copper and zinc levels and smoking, age, BMI or suffering from a chronic disease (P>0.05). Mean copper levels in women and men were not significantly with their respective different normal levels (P>0.05). Serum zinc level in men was lower than its normal range (P<0.05), but in women was not significantly different from its normal level.
Conclusion: Serum concentration of copper and zinc did not show any association with pemphigus disease. Since decreased levels of copper and zinc may result in an increase of oxidative activity in autoimmune diseases enhancing disease severity, therefore conducting a robust case-control study for evaluating the their roles in disease severity may pave the way to treatment of those diseases.
Nafiseh Esmaeili, Tahereh Soori, Nooshin Shirzad, Maryam Vahid-Moghadam, Abbas Karimi,
Volume 6, Issue 3 (Volume 6, Number 3 2015)
Abstract
Background and Aim: Pemphigus vulgaris is the most common autoimmune blistering disease. Prednisone, commonly in combination with an immunosuppressive adjuvant such as azathioprine or cyclophosphamide, is the standard treatment for pemphigus vulgaris. Approximately 5% to 15% of mortality of the disease is due to the complications of corticosteroids therapy. The aim of this study was to determine the prevalence and risk factors of steroid-induced diabetes in pemphigus patients hospitalized in Razi hospital, Tehran in 2009 and 2010.
Methods: In this cross-sectional study, 177 first-time admitted pemphigus vulgaris patients were studied regarding presence of risk factors for steroid-induced diabetes. Those risk factors were included age, sex, blood pressure, body mass index (BMI), family history of diabetes, medications used before and after initiation of treatment, fasting blood sugar (FBS) , triglyceride (TG) high density lipoprotein (HDL), low density lipoprotein (LDL) levels at the time of admission, and three weeks after the treatment was started.
Results: Twenty-nine patients (16.3%) were diagnosed with diabetes based on three weeks FBS levels evaluations. There were significant associations between BMI, HbA1c and taking nervous system agents and diabetes (P<0.05), but the differences between sex, family history, blood pressure, TG, LDL levels and occurrence of diabetes were not significant (P>0.05).
Conclusion: Close monitoring of FBS levels before and within the first three weeks of the initiation of steroid therapy allows early detection of storied-induced diabetes in pemphigus patients. Moreover, evaluation of other risk factors associated with diabetes may provide the opportunity of early diagnosis and treatment of steroid-induced diabetes.
Nafiseh Esmaeili, Zahra Karimi, Tahereh Soori, Abbas Karimi,
Volume 6, Issue 3 (Volume 6, Number 3 2015)
Abstract
Background and Aim: Pemphigus is a chronic autoimmune blistering disease characterized by intraepidermal blisters.
These blisters damage the skin barrier and increase the risk of life-threatening infections. Nasal colonization of
Staphylococcus aureus can increase the risk of infections and delay the wound healing process.The aim of this study was to
determine the frequency of staphylococcal carriers in hospitalized patients with pemphigus.
Methods: In this prospective cross-sectional study, medical records of 72 hospitalized patients with pemphigus in the
period from March 2013 to March 2014 were reviewed.Samples were collected from anterior nares and cultured at the
time of admission and one week after hospitalization for evaluation of S. aureus colonization and Methicillin-resistant
Staphylococcus aureus (MRSA) types.
Results: Forty-five patients (62.5%) were male and 27 patients (37.5%) were female. The frequency of S. aureus
carriers was 58.3%. Thirty patients had colonization at the time of hospital admission among them, 22 (73.3%) patients
had MRSA. In forty (55.6%) patients colonization were found one week after hospitalization. Thirty-three (82.5%) patients
in this group were MRSA positive. There was no significant difference between S. aureus colonization at the time of
admission and one week after hospitalization (P>0.05).
Conclusion: S. aureus and MRSA carriers (communityacquired and hospital-acquired carriers) were prevalent
among patients with pemphigus. With identifiction and isolation of carriers of S. aureus in pemphigus patients, not
only could prevent spreading S. aureus and MRSA associated infections, bul also would facilitate wound healing. More
robust studies are required to assess the role of potential riskfactors.
