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Frequency of primary generalized pruritus in bullous pemphigoid patients referring to Tehran Razi Hospital between 1996 to 2011
Nafiseh Esmaeili, Sedigheh Talebi, Kambiz Kamyab, Abbas Karimi,
Volume 5, Issue 4 (Volume 5, Number 4 2015)
Abstract

Background and Aim: Bullous pemphigoid (BP) is an acquired autoimmune disease with subepidermal blisters commonly seen in the elderly over 60 years. Although the disease is usually manifested with tense blisters, but in some cases generalized pruritus is the only symptom of disease, which is less studied.

Methods: In a retrospective study, the medical records of 416 BP patients confirmed in pathology laboratory were evaluated for clinical findings, direct immunofluorescence (DIF) testing for BMZ-binding IgG antibodies and histological findings.

Results: Of the 416 confirmed BP patients, 213 were male and 203 were female. The mean age of patients was 64.36 years. Thirty four patients at the onset of the disease had generalized pruritus, which in the course of the disease, 29 patients also showed other symptoms of the disease. In 5 patients generalized pruritus was seen as the only symptom. Concerning to the results of DIF, 117 (90%) patients showed autoantibody deposit, and in 13 (10%) patients the test was negative. There was no significant relationship between DIF results and histological findings (p> 0.05).

Conclusion: According to the findings of this study, generalized pruritus is uncommon as the first symptom of the disease. There was not any association between generalized pruritus and histological observations including dermal edema, presence of eosinophils in tissue, subepidermal blister as well as DIF results. Further studies on the early detection of the disease are required to decrease complications of the disease.
 
Prevalence of hirsutism and its related factors in dormitory students of Semnan University of Medical Sciences
Ramin Taheri, Abbas Ziari, Majid Mirmohammadkhani, Fateme Talebi Kiasari, Elmira Sadeghi Ivrigh,
Volume 7, Issue 1 (Volume 7, Number 1 2016)
Abstract

Background and Aim: Hirsutism as a clinical presentation of hyperandrogenism has a negative impact on the mental health and quality of life. Therefore, determination of its prevalence and associated factors in communities are important. The aim of this study was to determine the prevalence of hirsutism and its associated factors in dormitory students of Semnan University of Medical Sciences in Semana, Iran.

Methods: In this cross-sectional study, all of the female students of Semnan University of Medical Sciences dormitory were given a questionnaire which consists of three parts. The first two sections was designed to collect the demographic data and medical history including past medical history, drug history, menstrual condition and familial history of hirsutism. The third section included the grading scale of Ferrimen-Gallwey, that contains images of various parts of the body and hair growth. Participants were asked to determine their hair growth on the pictures. Data was analyzed using IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) version 19. Chi squared test was used for comparison of proportions in different groups.

Results: From 330 participants, 119 students (36.1%) complained from hirsutism. 105 (31.8%) patients had mild and 14 (4.3%) students had moderate hirsutism. There was a significant correlation between hirsutism and irregular menstrual cycles, positive familial history of hirsutism, congenital adrenal hyperplasia, polycystic ovary, hypothyroidism, use of danazol, and hoarseness (P<0.05).

Conclusion: This study showed a high prevalence of hirsutism in dormitory students of Semnan University of Medical Sciences. More clinical evaluation is suggested to determine various forms of hirsutism and the underlying conditions.


Evaluation of seasonal variation in acne vulgaris
Mohamad Shahidi Dadras, Hamideh Moravej, Ayda Bahman, Rezvan Aghili, Atefeh Talebi, Fahimeh Abdollahi Majd,
Volume 11, Issue 2 (Volume 11, No2 2020)
Abstract

Background and Aim: Acne vulgaris is one of the most common skin diseases in adolescents and young adults. Although acne do not physically disable the patient, it can cause significant psychological morbidities. The disease etiology is not fully understood; however, there are several factors involved in the pathogenesis. The aim of this study is to investigate the seasonal variation of acne vulgaris in patients referred to skin clinic of Shohaday-e-Tajrish Hospital in Tehran in 2017.

Methods: This study was a cross-sectional study in patients diagnosed with acne vulgaris by a dermatologist. One-hundred three eligible patients were enrolled in the study. The severity of acne was graded as mild, moderate or severe. In addition to the demographic data, information on the acne severity and changes in the acne severity in summer and winter had been recorded.

Results: The average age of 103 acne patients was 24.68±6.77 years. Sixty-eight patients were female and 35 cases were male. Fifteen (14.6%) patients had mild acne, 55 (53.4%) cases had moderate acne and 33 (32%) subjects had severe disease. In the summer, symptoms improved in 34 (33%) patients, worsened in 18 (17.5%) patients, and remained unchanged in 51 (49.5%) cases. In winter, symptoms improved in 15 (14.6%) patients, worsened in 37 (35.9%) patients, and remained unchanged in 51 (49.5%) patients (P=0.001). There was no significant relationship between changes in the severity of acne in winter or summer with age, age of the disease onset or duration or severity of acne (P>0.05).

Conclusion: In the present study, the number of patients with acne exacerbation in winter was significantly higher than that in summer. This may highlight the important role of winter in increasing the acne severity; however, more comprehensive studies with more sample sizes are still needed in different geographical areas.


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