Journal of

Background and Aim: Psoriasis vulgaris is a chronic skin disease which is treated by many systemic or topical drugs. There is no cure for this disease and patients have to take medicaments for a long time, so having knowledge on adverse effects of current medicaments may prevent them and improve treatment process. The aim of this study was to evaluate the incidence of side effects of non biologic systemic drugs in psoriasis.

Methods: In this observational study, we evaluated 200 hospital charts of patients with moderate to-severe psoriasis referred to dermatology clinics of Shohada and Loghman Hospitals in Tehran in 2016. SPSS statistical tools were used to determine the percentage of adverse events. Chi square was used to show the association of gender-related complications and student T-test to evaluate age-related complications.

Results: %56 of patients were male, %26.5 were 25-34 year-old, with mean age of 42±14.2 years and %83.5 of patients had no family history of psoriasis. 11% of patients were hypertensive. Methotrexate was the most commonly used drug and the most common reported adverse event for it was increasing liver function tests (%6.2 in oral and %21.2 in IM injections). The most common reported adverse event for cyclosporine was increased blood pressure which was seen in 17 patients (15.3%). The most common side effect of acitertin was scaling, observed in 11 (%9.6) of patients. There was no relationship between age and sex of patients and development of side effects.

Conclusion: This study showed systemic treatments for psoriasis can change laboratory biomarkers and cause skin eruptions.

Background and Aim: National studies on the prevalence of skin problems of the Iranian are very limited. The aim of this study was to determine the skin complaints of adult male population.
 

Methods: In this cross-sectional study, 1419 men over 35 years from 32 provinces participated by invitation. Demographic information, underlying disease history and presence of skin problems/diseases were collected by dermatologists. The participants were evaluated in terms of the presence of skin complaints (itching, burning, dry skin, redness, scaling, and skin color change); and any skin complaints with type, severity and location. 
 

Results: About one third 31.6% of the Iranian male middle-aged and elderly, had an underlying disease (n=449). High blood pressure, diabetes, and neurological disorders constituted 79.7% of the chronic diseases. In total, n=344 persons (24.2%) were rated as having skin complaint. Most people who had a skin complaint reported more than one skin complaint 75.6% (n=260). The most common skin complaints were related to itching 14.6% (n=207) and dry skin 5.6% (23.3%) in studied population, which were mostly mild 59.3% (n=204) and localize 58.4% (n=201). The use of corticosteroids was stated in 7.2%(n=103) and the most common types of usage was oral 62.1% (n=64). There was significant correlation between skin complaint and occupational exposure (P=0.01); lower education level (P=0.05); corticosteroid usage in general (P<0.001) and both oral (P=0.02) and topical (P<0.001) corticosteroid.
 

Conclusion: Skin complaint is common among middle-aged and elderly Iranian men. The most common skin complaint are mostly mild and localized itching and dry skin.