Alireza Firooz, Azin Ayatollahi, Farnaz Valizade, Mansour Nassiri Kashani, Zaghrabeigom Moosavi, Mahsa Fattahi,
Volume 13, Issue 2 (Volume 13, No 2 2022)
Abstract
Background: Tinea capitis is the term used for scalp infections caused by dermatophyte fungi. Tinea capitis is common in children and is less common in adults.
Case Report: The case was a 9-year-old girl with itchy patches of alopecia on the. The patient had a cat as a pet. On examination, the patch of hair loss was itchy and the hair shaft was broken and scales were mild. In the examination with Wood's lamp and direct microscopic examination, the ectothrix infection was deagnised. According to the dermatologist's opinion, a terbinafine 50 mg was prescribed daily. However, no significant improvement was observed despite 4 weeks of terbinafine. As a result, the dose of terbinafine treatment was changed from 50 mg to 250 mg per day. After 6 weeks of treatment, the clinical manifestations of the patient improved significantly.
Conclusion: After ringworm is confirmed microscopically, choosing the most appropriate antifungal treatment depends on determining the fungal species by culture. Therefore, when choosing empiric antifungal agent therapy, a dose of 250 mg terbinafine may be a good choice for children.
Farnaz Valizadeh,
Volume 14, Issue 3 (Volume 14, No 3 2023)
Abstract
Virtually all deaths in young patients with advanced skin tumors are caused by melanoma. Today, thanks to modern treatments, these patients survive longer or can even be cured. Advanced melanoma is often associated with a poor prognosis, and physicians continue to believe that the disease is difficult to treat due to the lack of durable response to initial treatment regimens and the lack of randomized clinical trials in the post-immunotherapy/targeted molecular therapy setting. New therapeutic targets are emerging based on preclinical data on the genetic profile of melanocytes and the identification of molecular factors involved in the pathogenesis of malignant transformations. In this article, we present the challenges of diagnosis, molecular biology and genetics of malignant melanoma, as well as current treatment options for patients with this diagnosis.
