Akram Ansar, Vali-O-Allah Hosseinpoor, Abbas Zamanian, Mahmood Farshchian,
Volume 3, Issue 1 (3-2012)
Abstract
Background and Aim: C-reactive protein (CRP) is an inflammatory biomarker and its level increases in serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index (PASI) score.Methods: CRP serum levels in patients with psoriasis were measured before and after treatment with narrow-band ultraviolet B (NB-UVB) and the data were analyzed in relation the PASI score improvement.
Results: Baseline CRP levels among psoriatic patients were higher than normal. These levels decreased significantly after treatment. At the beginning of the study, patients with higher levels of CRP also had more extensive and severe skin involvement. Highest decrease in CRP was observed in patients who responded better to the treatment and acheived higher PASI 75%. There was an association between baseline PASI scores and CRP levels.
Conclusion: Patients with moderate to severe plaque-type psoriasis had systemic inflammation too, which was demonstrated by having higher levels of CRP. Skin disease activity also was associated with higher levels of CRP. Phototherapy healed the psoriatic skin lesions and also reduced inflammation and decreased CRP levels.
Mahmood Farshchian, Elaheh Soltanie, Leila Moosavee, Hossein Mahjoob, Abbas Zamanian, Haleh Nazerian, ,
Volume 3, Issue 2 (6-2012)
Abstract
Background and Aim: Psoriasis is a chronic inflammatory
dermatosis that affects 0.6% to 4.8% of the general population. Our aim was to compare the effect of narrow band UVB
(NB-UVB) on normal flora of cutaneous plaques and normal skin in psoriatic
patients.
Methods: Twenty
psoriatic patients without any contraindication of phototherapy were enrolled
in this study. Samples from psoriatic lesions and adjacent normal skin, before
and after phototherapy with NB-UVB were taken. Patients were treated with
NB-UVB three times weekly until complete remission. Finally, quantity of normal
cutaneous flora on normal and involved skin, before and after treatment was compared.
Results: The mean±SD of
the NB-UVB sessions and the mean cumulative dose were 26.35±4.95 and 2.05±0.57 J/cm2, respectively. The number of Staphylococcus epidermidis, S. aureus and diphtheroids on psoriatic plaques reduced after phototherapy.
Conclusuion:
The quantity of normal cutaneous flora on normal skin is less than psoriatic plaques,
and it reduced on normal and involved skin after phototherapy.
Zahrabeigom Moosavi, Shayan Zamani,
Volume 14, Issue 4 (Volume 14, No 4 2024)
Abstract
Itch is one of the commonest complaints of patients of patients in skin clinics. Chronic itch is defined itch lasting more than 6 weeks, which suffers the patients and significantly reduces their quality of life. In this review, we explain pathogenesis and available treatments as a whole. In addition, we summarize pathogenesis and therapeutic options of some common conditions with chronic pruritus, except eczema, such as chronic kidney disease, cholestasis.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (Volume 15, No3 2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
