Showing 104 results for Skin
Pegah Tamimi,
Volume 16, Issue 1 (5-2025)
Abstract
Exosome therapy is emerging as a promising treatment in dermatology and aesthetic medicine due to its potential to promote skin regeneration, reduce inflammation, and improve wound healing. Exosomes are small extracellular vesicles secreted by cells, particularly stem cells, containing biological molecules such as proteins, lipids, and RNAs, which can be transferred to other cells to influence various physiological processes. This review explores the molecular mechanisms of exosome function, their clinical applications in skin rejuvenation, inflammatory skin diseases, wound healing, and hair loss treatments, as well as their potential use in cosmetic and clinical medicine. The article also discusses methods for exosome extraction, highlighting both chemical and physical techniques, and evaluates the advantages and limitations of exosome therapy, including the need for further clinical studies. Ultimately, exosome-based therapies hold great promise for non-invasive methods in dermatology and aesthetics, though further research is needed to optimize their use. Despite the exciting expectations surrounding, exosomes cannot yet be widely used as primary or definitive treatment options. Currently, no exosome-based products have received official approval from the U.S. Food and Drug Administration (FDA) as licensed drugs. Most human studies are still in early phases, such as phase I or II clinical trials, mainly focused on evaluating safety and preliminary efficacy. Therefore, the clinical application of exosomes remains largely limited to research settings or private clinics, and broader medical use awaits more extensive studies and regulatory approvals.
Faezeh Roshanbakht, Nahid Hassanzadeh Nemati, Neda Attaran Kakhki,
Volume 16, Issue 1 (5-2025)
Abstract
Skin infections caused by pathogenic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa have become a serious challenge in the field of antibacterial therapies, especially in the context of antibiotic resistance. In this regard, the simultaneous use of classical antibiotic combinations with advanced nanostructures is considered a novel and effective approach. Narasin, an ionophore antibiotic of natural origin, has a high potential in inhibiting bacterial growth due to its ability to disrupt cell membrane function and ion transport. On the other hand, silica nanostructures, especially mesoporous silica nanoparticles, play an important role in enhancing antibacterial activity due to their properties such as biocompatibility, drug loading capability, controlled release, and production of reactive oxygen species.
Recent studies have shown that the combination of narasin with silica nanostructures enhances the synergistic antibacterial effects, increases drug stability, and improves penetration into bacterial biofilms. This combination has also been effective in reducing the dosage and systemic toxicity. Despite promising results in laboratory and animal models, challenges such as the assessment of cytotoxicity, precise release control, and the need for extensive clinical studies remain.
In this article, while comprehensively reviewing the properties and functions of narasin and silica nanostructures, the mechanisms of their combined effects on skin pathogenic bacteria are discussed and future prospects in the development of nanobiotechnological therapies are reviewed.
Forouhe Zahirjouzdani, Farid Mohamadi,
Volume 16, Issue 2 (7-2025)
Abstract
The health of the skin and hair serves not only as an indicator of overall physiological well-being but also plays a significant role in personal appearance and self-confidence. A range of intrinsic and extrinsic factors-including genetics, hormonal balance, environmental exposures, and, most notably, nutrition-affect the maintenance and integrity of skin and hair. Micronutrients, comprising essential vitamins (such as B-complex, C, and E), minerals (including zinc), and bioactive phytochemicals with antioxidant and anti-inflammatory properties (such as astaxanthin), play a critical role in supporting the structural and functional health of these tissues. These compounds contribute to the regulation of cellular metabolism, mitigation of oxidative and inflammatory damage, and enhancement of immune function, thereby aiding in the prevention of common dermatological and hair-related conditions such as dryness, hair loss, and premature aging, and promoting overall skin and hair health.
Hanie Bakhtiyari, Mohamadsaeid Emaminia, Amin Bakhtiyari,
Volume 16, Issue 3 (11-2025)
Abstract
Skin aging is a complex process characterized by structural alterations, reduced elasticity, and wrinkle formation, adversely affecting self-confidence and quality of life. Emerging evidence indicates that epigenetic mechanisms—including DNA methylation, histone modifications, and microRNA regulation-play pivotal roles in initiating and progressing these changes. These modifications, which occur without altering the DNA sequence, are reversible and thus represent promising targets for rejuvenation interventions. This review provides a comprehensive analysis of the role of these pathways in skin aging, as well as the impact of environmental factors such as ultraviolet (UV) radiation, air pollution, and nutrition. Furthermore, it discusses innovative therapeutic strategies, including Sirtuin activators, histone modification inhibitors, platelet-rich plasma (PRP), cell-based therapies, and epigenetic editing technologies. Although preliminary results are encouraging, limitations such as the paucity of longitudinal studies, methodological heterogeneity, and safety and ethical concerns remain. Overall, a deeper understanding of epigenetics may open new avenues for personalized and non-invasive skin rejuvenation therapies.
