Showing 104 results for Skin
Zahrabeigom Moosavi, Alireza Firooz,
Volume 11, Issue 3 (10-2020)
Abstract
In this issue, the third article about COVID-19 is published. It consists of the most beneficial and new findings after the previous issue. It has been attempted to explain different aspects of SARS-Cov2 infection and its effects on human social and personal aspects .Nowadays manuscripts on present pandemic are showery and ongoing published. Therefore it is not possible to review all of them, however the authors have done all their best to select and present the most important.
Malahat Khateri Roodbordeh, Nahid Hassanzadeh Nemati,
Volume 11, Issue 4 (1-2021)
Abstract
Background and Aim: Lesions of the skin can impair its vital function to protect humans against external pathogens. Therefore, producing a suitable wound dressing to repair injuries is always one of the challenges of researchers. The present study aims to Synthesize a hydrogel film for wound dressing applications.
Methods: In this research, a hydrogel film of polyvinyl alcohol / hyaluronic acid / nano zinc oxide was fabricated for application as a wound dressing. For this purpose, three films with different percentages were prepared using the solvent casting method. The synthesized samples were characterized using FTIR, SEM, XRD, and tensile tests.
Results: Evaluation of the morphology of the samples showed that the increase of zinc oxide nanoparticles led to porosity and growth of their size in the films. It was also characterized that the percentage of film elongation increased with increasing nanoparticles of zinc oxide and hyaluronic acid. The elongation percentage from the lowest amount of nano zinc oxide to the maximum (5, 10 and 15% of weight was 159%, 166%, and 230%, respectively. The MTT study indicated the cell viability above 80% in all three films.
Conclusion: A film containing 15% zinc oxide can be a suitable option for using in tissue engineering and wound dressing.
Zahra Shadabi, Athar Moin, Ali Davati,
Volume 11, Issue 4 (1-2021)
Abstract
Background and Aim: Patients' complaints against doctors and medical malpractice is one of the most serious and challenging issues in the medical profession. Due to the importance of this issue and the lack of sufficient information about skin and beauty complaints in the medical system. The purpose of this study is to investigate and identify skin and beauty complaints referred to the Tehran Medical System Organization.
Methods: In this descriptive-analytical and retrospective study, all cases of complaints of medical malpractice in the field of dermatology in the medical system of Tehran province from 2014 to 2019 were reviewed and after collecting information, the data were analyzed using SPSS statistical software (SPSS Statistics 25).
Results: Of the total cases, 1.6% were related to skin and beauty. Most of the plaintiffs were female (79.8%) and single (59.6%). The attending physicians were mostly male (79.8%) and general practitioner (48.1%). The most common type was private medical center (95.2%). The most common complaints were treatment complications (36.7%), most of which were related to the side effects of Botox or fat injections (15.4%) and then laser complications (12.5%). The most common type of negligence was carelessness (30%) and 20.7% of cases were declared negligent. The highest percentage of verdicts was written reprimand and inclusion in the file (42.3%).
Conclusion: Physicians should avoid engaging in unrelated disciplines and unscientific practices. Reducing financial relationships and emphasizing the physician's proper interaction with the patient and adhering to a professional commitment are helpful in preventing complaints.
Sara Bahrainian, Atefeh Naeimifar, Saman Ahmad Nasrollahi,
Volume 11, Issue 4 (1-2021)
Abstract
Full term newborns have a skin that rapidly develops towards adult skin. From the anatomical point of view, the differences are limited, but some changes at birth are responsible for the physiological differences between the skin of infants and adults. Newborns skin exhibits the same barrier function and absorption properties as adults, but external conditions for newborns may be different from those for adults, and these differences may lead to different skin absorption profiles between these two groups. Also, a baby's temperature regulation (transepidermal water loss (TEWL) and sweating) is not completely developed and the skin becomes easily infected, which is mainly due to changes in pH and immaturity of the skins defense system. This implies why only cosmetics with safe ingredients should be used for newborns. The initial aim is to formulate a simple, pure, gentle and pathogen-free product. Systemic side effects are not expected with washable products but should be taken into account for leave-on products. Great attention should be given to cosmetic products used in the napkin area, especially where there is a possibility of rash. If necessary, more safety precautions should be taken for these products.
Zahrabeigom Moosavi, Alireza Firooz,
Volume 12, Issue 2 (8-2021)
Abstract
The sixth article of COVID-19 review series is published while the virus is invading the world. In this issue, lastest findings about skin manifestations of this disease, skin diseases course, also diagnosis and treatment of COVID-19 and skin reactions due to vaccines are presented.
Amir Hosseinalibeygi, Morteza Kashani, Mansour Nassiri Kashani,
Volume 12, Issue 2 (8-2021)
Abstract
Sports and the development of nations are very much intertwined. Sports dermatology is a growing discipline. Athletes’ skin diseases are a distinct group of diseases, and that repetitive physical activity combined with environmental stressors puts the athlete at the highest level of risk.The purpose of this study is to equip physicians with basic knowledge of skin diseases in athletes. Lack of knowledge about the role of exercise in the pathogenesis of skin diseases can lead to delayed diagnosis and consequently, incorrect treatment. Skin diseases can be caused directly or indirectly by exercise; there are some skin diseases which exist in a person but appear or intensify with the onset of exercise.
In general, before an athlete should exercise, he should be examined dermatologically to prevent the spread of skin diseases. They should be considered especially for lesions on the less noticeable areas such as the back and inner side of ears. It is better to prepare a map of the patient’s lesions that can be tracked over time, which the possibility of following their changes (Body Mapping).
Athletes should have no general symptoms such as fever for 72 hours before exercising. There should be no secretory skin lesions, otherwise, it is necessary to receive treatments before going to the gym and using the equipment to ensure that the disease does not spread to others.
Zahrabeigom Moosavi, Alireza Firooz,
Volume 12, Issue 4 (2-2022)
Abstract
The COVID-19 pandemic is still present and we are directly or indirectly affected by it. The skin is one of the organs that has some manifestations not only during the course of the disease, but also long after recovery and also after vaccination. Hair is one of the parts that, like the skin, may show disorders during and after recovery of the infection and also after vaccination. In this issue, we aimed to provide an overview of the effects of COVID-19 and vaccination on hair. We also express the instrumental role of hair in the study of other diseases, including psychological problems.
Aniseh Samadi, Hasti Ahmadianyazdi, Maryam Ahmadi, Atefeh Naeimifar, Saman Ahmadnasrollahi, Alireza Firooz,
Volume 12, Issue 4 (2-2022)
Abstract
Background and Aim: Although several commercial moisturizers are available in the market, continued role of pharmaceutical compounding have been still felt in dry skin management. This study aimed to evaluate the effect of a two urea- based compounded moisturizers on barrier function, compared to similar commercial product. 15 volunteers (14 females and one male) age 36.15 ±9.55 years old (range 21-56 years old) with non-pathologic dry skin, recruited to the study applied 5% urea containing hydrophilic petrolatum and 10% urea containing hydrophilic petrolatum during two following phases.
Methods: Upper parts of right and left forearms randomly were assigned for twice a day application of commercial or compounded products. Biophysical assessments including trans epidermal water loss (TEWL), skin hydration, friction co efficient, pH and surface lipids, performed before intervention, 1, 4 after single application and at 24 hours and one week twice daily application.
Results: In both phases, commercial and compounded moisturizers showed appropriate and comparable effect on skin barrier function compared to the baseline. However commercial products, led to better improvement in TEWL, 4 hours after single application in both phases (P=0.04). The rate of increase in skin hydration was also significantly higher for commercial emollient, compared to compounding product (57.48±11.23 vs. 50.59±11.42, P=0.01).
Conclusion: Commercial formulation led to higher acceptability and better improvement on skin barrier function after single application, probably due to influence of excipients. Present study did not find sufficient added value for pharmacy product relative to commercial one and suggest to be replaced in similar condition.
Kiana Shomali, Atefeh Naeimifar, Saman Ahmadnasrollahi,
Volume 12, Issue 4 (2-2022)
Abstract
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%),
urea-containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea-based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti-inflammatory and anti-fungal drugs, due to its activity as a penetration enhancer.
Pedram Noormohammadpour, Amirhooshang Ehsani, Ifa Etesami, Amin Rahmani,
Volume 13, Issue 1 (5-2022)
Abstract
Background and Aim: Skin injuries with various causes may lead to legal action. Complaints are referred to specialized authorities such as Razi Hospital, before specialized forensic medicine commission comment. The present study surveyed demography of patients' complaints and initial diagnosis at the time of referral over a period of 6 months.
Methods: In this retrospective study, patients referred for initial visit, from Forensic Medicine Office in the September 2018-March 2019, were examined. The patients' complaints at the time of referral and the clinical diagnosis made at the initial examination were recorded.
Results: A total of 220 patients including 176 women (80%) and 44 men (20%) with a mean age of 34.8 years were included. 42 different complaints were documented, including traumatic hair loss with 91 cases (41.4%) - the most common - followed by complications of laser hair removal with 32 cases (14.6%) and filler injections with 16 cases (7.3%). Scarring from trauma, reaction to chemicals during work or accidental contact, rare injuries from various treatments, and even cases of pediculosis (contamination of the accommodation) or zoster (complaint about care in the treatment center), etc. were observed.
Conclusion: Traumatic hair loss (mainly due to fight) was the most common complaint. Knowing other cases may expand physicians' awareness regarding the wide range of complaints that can be raised and improve the process of some treatment measures.
Pegah Abbasi, Maryam Peymani, Dariush Farhud, Hamidreza Mahmoudi, Kamran Ghaedi,
Volume 13, Issue 2 (8-2022)
Abstract
Background and Aim: Considering the high global incidence of skin cancer and the high mortality rate caused by melanoma, it is important to identify the genes involved in this disease and predict effective drugs. Therefore, in this study, we have identified and investigated the expression level of effective and key genes in melanoma metastasis, as well as investigating their diagnostic potential as biological markers and finding effective drugs on the expression of these genes.
Methods: In this study, we have used 46 cancer samples without metastasis and 12 cancer samples with metastasis from the GEO database and from the GSE15605 study with 74 samples including 16 normal samples. Gene expression profile in this study was generated by GPL570 platform containing 54675 probes. The latest GPL570 annotation file has been downloaded and initial processing was done.
Results: The results showed that the expression level of candidate genes in metastasis samples had a significant change compared to normal samples. The results of analysing the data related to candidate genes in this study indicated that the drugs Glucosamine, Ad-E2F-1 plus Doxorubicn, GSI, Torcetrapib, Ribavirin and NSC319726 could be effective on the expression of MYH10, SPRR3 and TOP2A genes, respectively. On the other hand, the results from the drug bank database revealed that various drugs such as Amsacrine, Dexrazoxane, Valrubicin, Teniposide can have an inhibitory role on the TOP2A gene.
Conclusion: GEO database was used to identify key genes in melanoma metastasis and DRUGBANK was used to identify drugs that affect the expression of these genes.
Fatemeh Yazdani Hamid,
Volume 13, Issue 2 (8-2022)
Abstract
Skin cancers are highly prevalent malignancies that affect millions of people worldwide. These include melanomas and nonmelanoma skin cancers. Melanomas are among the most dangerous cancers, while nonmelanoma skin cancers generally exhibit a more benign clinical pattern; however, they may sometimes be aggressive and metastatic.
Melanomas typically appear in body regions exposed to the sun, although they may also appear in areas that do not usually get sun exposure. Thus, their development is multifactorial, comprising endogenous and exogenous risk factors. The management of skin cancer depends on the type; it is usually based on surgery, chemotherapy, immunotherapy, and targeted therapy. In this respect, oncological treatments have demonstrated some progress in the last years; however, current therapies still present various disadvantages such as little cell specificity, recurrent relapses, high toxicity, and increased costs. Furthermore, the pursuit of novel medications is expensive, and the authorization for their clinical utilization may take 10-15 years. Thus, repositioning of drugs previously approved and utilized for other diseases has emerged as an excellent alternative. In this mini-review, we aimed to provide an updated overview of drugs’ repurposing to treat skin cancer and discuss future perspectives.
Parviz Toosi, Seyedhasan Etemadzadeh, Mohammadreza Sedighimoghadam, Batool Mousavi, Seyedehfatemeh Nouri Rahimabadi, Fahimeh Abdollahimajd, Mohammad Roustanezhad Arabani, Aliakbar Babaei, Shahram Ariaeenejad,
Volume 13, Issue 3 (11-2022)
Abstract
Background and Aim: National studies on the prevalence of skin problems of the Iranian are very limited. The aim of this study was to determine the skin complaints of adult male population.
Methods: In this cross-sectional study, 1419 men over 35 years from 32 provinces participated by invitation. Demographic information, underlying disease history and presence of skin problems/diseases were collected by dermatologists. The participants were evaluated in terms of the presence of skin complaints (itching, burning, dry skin, redness, scaling, and skin color change); and any skin complaints with type, severity and location.
Results: About one third 31.6% of the Iranian male middle-aged and elderly, had an underlying disease (n=449). High blood pressure, diabetes, and neurological disorders constituted 79.7% of the chronic diseases. In total, n=344 persons (24.2%) were rated as having skin complaint. Most people who had a skin complaint reported more than one skin complaint 75.6% (n=260). The most common skin complaints were related to itching 14.6% (n=207) and dry skin 5.6% (23.3%) in studied population, which were mostly mild 59.3% (n=204) and localize 58.4% (n=201). The use of corticosteroids was stated in 7.2%(n=103) and the most common types of usage was oral 62.1% (n=64). There was significant correlation between skin complaint and occupational exposure (P=0.01); lower education level (P=0.05); corticosteroid usage in general (P<0.001) and both oral (P=0.02) and topical (P<0.001) corticosteroid.
Conclusion: Skin complaint is common among middle-aged and elderly Iranian men. The most common skin complaint are mostly mild and localized itching and dry skin.
Poorandokht Afshari, Maryam Beheshtinasab, Mohamad Javadmohamadi, Elham Maraghi, Maria Cheraghi,
Volume 13, Issue 3 (11-2022)
Abstract
Background and Aim: Importance of hand hygiene with the COVID-19 has been raised around the world from 2019. We aimed to determine the effect of hand skin health in menopausal women during the covid-19 pandemic.
Methods: It was a cross-sectional study which has conducted on 94 subjects those were referred to menopause clinic in Imam Khomeini Hospital in Ahvaz city during September to November 1999. The tools of this study were the Personal Characteristics Questionnaire and Hand and skin self-assessment tool (Appendix 3 of “WHO GUIDELINES ON HAND HYGIENE IN HEALTH CARE “). Data has entered and analyzed by using software SPSS version 22. The level of significance was considered as less than 0.05.
Results: The mean age of women participating in the study was 53.6. The average frequency of hand washing outdoors was 5.28 and 10.43 indoors. Most women (94.7%) had reported at least some degree of skin problem and reported that their hand skin problems increased significantly during the COVID-19 pandemic.
Conclusion: Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.
Javad Rahmati, Shahriar Haddady Abianeh, Hosseinali Abdolrazaghi, Hojjat Molaei,
Volume 13, Issue 3 (11-2022)
Abstract
Background: Skin lesions and need for tissue evaluation, makes skin surgery an important part of treatment. Each excision is accompanied by skin repair. One of side effects of lesion excision is dog ear and cosmetic problems, particulary on face.
Case Report: A middle age woman presented with an old leishmaniosis scar in her face. she asked how can we remove the lesion with minimal scar. In the planned operation the lesion was excised some deeper fatty tissues at both ends. At the end of wound closure, there was not ant dog ear around wound.
Conclusion: There are numerous options to prevent and correct dog ears at the end of skin closure- depending on size and location of the lesion. in our recommended technique, subdermal fatty excision attached to the lesion, may remain minimal extra skin at the end of skin closure.
Hasti Ahmadian Yazdi Ahmadian Yazdi, Alireza Firooz, Maryam Movafegh, Faegheh Kazemi, Saman Ahmadnasrollahi, Aniseh Samadi,
Volume 13, Issue 4 (2-2023)
Abstract
Background and Aim: Oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumers. The purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration and roughness.
Methods: It was a 12-week, before-after clinical study, conducted on 20 participants (18 women and two men) aged 44.15±5.36 years with skin type III-IV. Skin elasticity parameters (R0, R2, R5 and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as four weeks after stopping its use (week 16). Participants’ satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.
Results: A significant improvement was detected in R2, R5 and skin friction at week 12 (P<0.041, P<0.012 and P<0.01, respectively). At week 16, the values remained at an increased level, which indicates the stability of the results. The increase of dermis density in week 16 was also significant (P=0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.
Conclusion: The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.
Sharareh Rezaeian, Hamidreza Pourianfar,
Volume 13, Issue 4 (2-2023)
Abstract
Reishi mushroom (Ganoderma lucidum) is a unique medicinal mushroom that has been used for the treatment of various diseases in Asian countries for more than 4 thousand years. Today, this mushroom is also used in treatments related to traditional medicine. In addition to its diverse biological properties, its positive effects in improving the quality of the skin and treating skin diseases have attracted the attention of researchers. Polysaccharides and triterpenes are among the most important and effective metabolites of this mushroom, which are important in skin treatment and health due to their antioxidant and anti-inflammatory functions. This review summarizes the latest research achievements on the role of this mushroom in skin health and treatment. A number of studies have shown that the extracts of Reishi mushroom can accelerate wound healing, relieve post-burn infections, and prevent skin flaps due to ischemia (re-perfusion) damage. The effect of Reishi mushroom extracts on the prevention and treatment of wrinkles and the effect on skin whitening has made them a natural ingredient for skin care. Also, studies conducted on the effects of Reishi mushroom in the treatment of some skin diseases such as atopic dermatitis (eczema), cutaneous sarcoidosis, and the potential use of this mushroom in the treatment of skin cancer have been discussed.
Atoosa Asadollahi, Bahareh Nowruzi, Mahsa Fattahi,
Volume 13, Issue 4 (2-2023)
Abstract
Microalgae are photosynthetic microorganisms which are the result of permanent exposure to stressful conditions such as high or low temperature, high salinity, osmotic pressure, ultraviolet radiation (uv), contain valuable bioactive compounds in cosmetic products .the existing cosmetic products can be replaced with the cosmetic products that are compatible with the environment and can be included in the topical formulations of skin care such as moisturizers, Anti-wrinkles, anti - aging and anti - acne. In addition, the extracts from these microalgae are used to make sunscreen to treat skin pigmentation and improve wounds; therefore most commercial cosmetics have a wide range of natural compounds extracted from cyanobacteria and this leads to increasing antioxidant, regenerative, moisturizer, shielding and brighteners for both hair and skin. In this article the cosmetic use of cyanobacteria extract and dried powder in improving the appearance and health skin have been investigated. Furthermore, analyzing the brand of Spirulina has been discussed.
Hamideh Herizchi Ghadim, Alireza Salehi, Hanieh Asadpour,
Volume 14, Issue 1 (5-2023)
Abstract
Introduction: Chondroidsyringoma or apocrine mixed tumor is a benign skin tumor that usually manifests as a nodular lesion with slow growth and no symptoms in the head and neck area, and based on histologicalcharacteristics, it can be apocrine or eccrine. Tumor diagnosis is based on clinical features and histopathology and its treatment is surgical removal of the lesion.
Case report: In this study, we report a case of apocrine chondroidsyringoma in a 33-year-old man who presented with a complaint of an asymptomatic nodular lesion in the area above the upper lip, and after biopsy and histopathological examination, the diagnosis of apocrine chondroidsyringoma was made.
Conclusion: Chondroidsyringoma does not have a specific clinical manifestation and its diagnosis is challenging and is based on attention to histological features in addition to clinical manifestations. This tumor should be considered in the differential diagnosis for subcutaneous nodules, especially in the head and neck area.
Javad Rahmati, Hosseinali Abdolrazaghi, Shahriar Haddady Abianeh, Hojjat Molaei,
Volume 14, Issue 2 (8-2023)
Abstract
Introduction: Skin lesions and masses of forehead are challenging topics in the field of reconstruction. Skin grafts and local flaps have significant role in reconstruction of skin defects of forehead. Proper design of flap can save hairline configuration and symmetry of eyebrows.
Case report: A young woman with congenital sebaceous nevus-Jadassohn-wanted to remove this lesion. After excision, there was skin defect of 4 cm diameter. A O to T flap designed and incisions were on bilateral hairline. The defect was covered without any disruption of hairline.
Conclusion: Rotational-advancement flaps are among reliable flaps in reconstruction of forehead skin defects. O to T flap belongs to this category which is effective in traumatic patients and reconstruction following tumor resections.
