Showing 104 results for Skin
Parham Tamimi,
Volume 14, Issue 3 (11-2023)
Abstract
Parkinson Disease (PD) is a neurological disorder, which have comorbidity with some skin disorders. Skin disorders in Parkinson can be divided into two main groups including 1) non-iatrogenic disorders: melanoma, seborrheic dermatitis, sweating disorders, pemphigoid, rosacea, and 2) Iatrogenic disorders due to anti-Parkinson drugs side effects (like: carbidopa/levodopa, rotigotine, other dopamine agonists, COMT inhibitors and SC Apo morphine).
While seborrheic dermatitis is considered as a pre diagnostic sign, rosacea can be assumed as a warning sign of disease development. In addition, a strong correlation between PD and further bolus pemphigoid has been discovered. There might be a relation between melanoma and PD. It is important especially in patients with lighter skin with red and blond hair color. Hence, physicians should pay special attention in these patients and try to increase awareness in this population like reminding the importance of sun protection.
Maryam Nourizadeh, Mahsa Fattahi,
Volume 14, Issue 4 (2-2024)
Abstract
Methotrexate (MTX) is a freely available medication. However, regardless of extensive off-label consumption, FDA labeling does not include accepted for the consumption of MTX for many inflammatory skin diseases in pediatrics, containing morphea, psoriasis, atopic dermatitis, and alopecia areata. Lacking published healing recommendations makes the clinicians unsure about prescribing MTX in an off-label manner especially in children. Present study, was conducted to review the use of MTX to heal pediatric inflammatory skin disorders.
The evidence and consent based advices will assistance safe and successful use of MTX for the underserved population of pediatrics who may benefit from this valuable, time-honored medication.
Pegah Tamimi, Parham Tamimi, Aliasghar Ghaderi,
Volume 14, Issue 4 (2-2024)
Abstract
Dysregulation of long non-coding RNA may lead to various diseases including cancer. Recently, many lincRNAs have been discovered for their important roles in melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). These long non-coding RNAs are involved in skin cancer cell proliferation, angiogenesis, invasion, and metastasis.
Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.
Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.
Samira Shahhosseini, Moazameh Kordjazi, Saman Ahmadnasrollahi, Seyedmahdi Ojagh, Atefe Naeimifar, Salim Sharifian,
Volume 15, Issue 1 (5-2024)
Abstract
Background and Aim: Marine seaweeds are a valuable source of bioactive ingeredients with the possibility of different effects in cosmeceutical industries such as skin health products. One of the main characteristics of the skin is moisture which plays an important role in maintaining metabolism, enzymatic activity, mechanical properties, appearance and protective barrier. The objective of the present study was to formulate the water extract of brown algae Sargassum tenerrimum with antioxidant and antibacterial properties as a moisturizing cream to evaluate physicochemical stability and microbial growth.
Methods: Algae were collected from the Persian Gulf intertidal zone and was washed with seawater, then transferd to Seafood Processing Laboratory in Gorgan University of Agricultural Sciences and Natural Resources for extraction process, after that formulation of 1% moisturizing cream was made at Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical Scinces. Statistical analysis of antibacterial properties of water extract was performed by SPSS software version 22 and one way ANONA was used to analyse the data. The comparison between the means were investigated by Duncan’s test used for measuring significant differences at 5 percent level. Finally, the charts were created by using Excel software. The results of the study were reported as mean ± standard deviation.
Results: According to the results, the prepared 1% cream was completely stable and homogeneous in room temperature and oven for 6 months and successfully passed microbial tests.
Conclusion: In view of the above mentioned, the manufactured cream efficacy was well done and can be introduce as a skin moisturizing agent.
Mahdieh Ghiasi, Seyedkhalil Pestehei, Seyedamirhossein Javadi, Seyediman Seyhoun,
Volume 15, Issue 1 (5-2024)
Abstract
The skin, as the outer layer, protects the body against external factors. Wounds can negatively affect its performance. Wound healing includes three stages of inflammation, proliferation, and regeneration, which begin immediately after injury. Also, some factors such as infection, obesity and diabetes can disrupt the natural healing process that leads to chronic wounds. Various surgical and non-surgical treatments have been used to manage chronic wounds, including hyperbaric oxygen therapy, ultrasound therapy, laser therapy, and skin grafting. These treatments have advantages and disadvantages. Recently, stem cells have been used as a surgical treatment for chronic wound healing. Stem cells are highly proliferative cells that can maintain their ability to divide and regenerate for a long time. Among the different types of stem cells, MSCs have many advantages such as ease of harvest, availability, and multilineage differentiation capacity for cell therapy. In addition, they showed some properties that could be useful in the clinical application of ASCs, including angiogenesis, immune system modulation, and improved tissue regeneration. This study was conducted by collecting data from reliable scientific sources from April 1401 to January 1402 at the Research Institute of Neurosciences, Brain and Spinal Cord Injury Research Center of Tehran University of Medical Sciences. Several studies have shown that ASCs can be a suitable candidate for wound healing due to their special characteristics. The purpose of this review is to discuss the use of ASCs in wound repair and healing as a new strategy in the treatment of skin problems.
Tayebeh Momeni, Alieh Safamanesh, Faezeh Kashanian,
Volume 15, Issue 1 (5-2024)
Abstract
Chitosan biopolymer, due to its antimicrobial, anti-inflammatory, and antioxidant properties, has become an ideal candidate for use in a wide range of cosmetic products and has opened up new horizons in the design of cosmetic formulations. The ability of this polymer to electrostatically interact with negatively charged surfaces (such as damaged skin) leads to the formation of polymeric films and ultimately imparts smoothness and moisture to cosmetic products. This review article revisits the potential of chitosan and its derivatives as raw materials in cosmetic and skincare products.
Nahid Hassanzadeh Nemati, Kimia Rezaie Moghadam,
Volume 15, Issue 1 (5-2024)
Abstract
Cosmetic dermatology has seen significant advancements in developing new materials and techniques to enhance skin beauty and combat signs of aging. One notable development is creating and analyzing fillers made by combining hyaluronic acid and polycaprolactone. This innovative filler type has gained popularity due to its unique properties, exceptional skin rejuvenation capabilities, and effectiveness in facial contouring. This study gathered information on dermal fillers and the effects of using hyaluronic acid and polycaprolactone by referencing papers from various databases such as Civilica, PubMed, Google Scholar, Science Direct, and SID. The authors conducted a study to explore the benefits and drawbacks of utilizing hyaluronic acid and polycaprolactone and their impact on filler durability and injectability. Research conducted by experts and studies on cosmetic fillers has highlighted the positive effects of hyaluronic acid and polycaprolactone, two powerful substances widely discussed in the beauty industry. Further research could improve the understanding and utilization of hyaluronic acid/polycaprolactone fillers, enhancing skin cosmetic treatments and increasing patient satisfaction.
Bahareh Nowruzi, Mohammad Jabari, Zeynab Yassin,
Volume 15, Issue 1 (5-2024)
Abstract
Worldwide, 16,000 deaths occur daily due to wound injuries, leading to increased concern in low- and middle-income countries. Today, with the increasing demand of consumers to use natural biological compounds instead of using harmful and carcinogenic chemical compounds, algae were introduced to the market as an effective clinical skin alternative. In fact, ease of cultivation and low nutritional requirements make algal polysaccharides an attractive alternative for advanced wound dressings. Micro and macroalgae are a new source of biological saccharide polymers for wound healing. The hydrophilic nature of these polymers due to their capacity to trap water molecules in their structure makes hydrogels that have a high ability to absorb and release liquid. In this review article, by studying the latest articles, some algae polysaccharides that are widely used as wound healing dressings such as alginates, fucoidans, carrageenans, laminarin, agar-agar and olvan are discussed. These compounds are not only used as functional biomaterials for controlled drug delivery, but also for cell stabilization and preparation of scaffolds for tissue engineering.
Zahrabeigom Moosavi,
Volume 15, Issue 1 (5-2024)
Abstract
Development of janus kinase inhibitors (JAKi), has significantly modified treatment of various dermatological conditions by targeting essential pathogenesis of inflammatory and autoimmune diseases. Despite therapeutic potentials of these drugs, concerns about safety appeared soon postmarketing consumption. Therefore implementing strong studies to evaluate their safety and efficacy became mandatory. Many studies have been done up to now focusing on JAKi’s serious or acceptable side effects, however, they are often retrospective or have short follow up. Due to importance of JAKi’s role in the treatment of many skin diseases, we decided to present a review on the main points of recent studies, particularly systematic reviews and clinical trials regarding serious side effects.
Ala Ehsani, Amirhoushang Ehsani, Zahra Razavi, Mina Koohian Mohammadabadi, Mahshidsadat Ansari, Zeynab Aryanian, Pedram Nourmohammadpour, Amirmohammad Almasi, Amirhossein Rahimnia,
Volume 15, Issue 2 (8-2024)
Abstract
Background and aim: As the use of botulinum toxin to treat glabellar lines increases, particularly in Iran, where foreign products (e.g. Dysport) are relatively expensive, it becomes important to compare the efficacy, side effects, and duration of action of two locally produced botulinum toxin brands, Masport® and Dyston®. This study seeks to assess and compare the treatment results of these two medications.
Methods: In this cross-sectional, descriptive, retrospective study, the medical records of 81 patients who visited Razi Dermatology Hospital for the treatment of moderate to severe glabellar lines were reviewed. Data related to patient satisfaction, duration of action, and side effects of Masport® and Dyston® botulinum toxin were collected and analyzed via a questionnaire.
Results: The mean satisfaction score was 7 for the Dyston® group and 7.7 for the Masport® group, with no statistically significant difference between the two groups (P=0.142). Additionally, the mean duration of action was 3.5 months for Dyston® and 3.8 months for Masport®, with no significant difference observed. Headache was the most common side effect reported, with no other major adverse events noted. Furthermore, there was no statistically significant difference in the incidence of side effects between the two groups.
Conclusion: The findings of this study indicate that both Dyston® and Masport® have similar efficacy and safety profiles. The choice between them can be primarily based on cost and patient or physician preference rather than any significant therapeutic differences. Larger studies are recommended to further validate these findings.
Alireza Mohebipour, Firouz Amani, Mitra Razmi, Masoud Amanzadeh, Mohammad Bahrami,
Volume 15, Issue 2 (8-2024)
Abstract
Background and Aim: Cancer is the second leading cause of death in the world, as well as skin cancer is the most common cancer among human cancers and causes great costs and economic and social harm to society. The increase in skin cancer in our country and also in Ardabil province led us to study the prevalence and epidemiological trend of 10 years of skin cancer in patients referred to the skin clinic in Ardabil 2011-2021.
Methods: In this study, 331 patients had been referred to a dermatology clinic with a diagnosis of skin cancer during 2011 to 2021. The checklists were completed based on the information in their files.
Results: Of all patients, 208 (62.8%) were male, 60.4% from Ardabil, 14.2% were in year 2016 and 46.2% were in the age group of 50-70 years. The mean age of patients was 62.5±14.7 in range 25-96 years. The most common type of skin cancer in the studied samples during ten years was related to BCC with 184 cases (55.6%) and the most studied patients were in grade 3 with 231 patients (69.8%). The most common site of skin cancer with 93 cases (28.1%) was in the nose.
Conclusion: Results showed that the trend of skin cancer in the studied samples similar to the provincial statistics did not have a constant decrease or increase trend and had a fluctuating trend. The incidence of this disease in male clients was about twice that of female clients and most cases were in high grades and BCC type.
Mehdi Mirzaei Alavijeh, Mahin Amini, Farzad Jalilian,
Volume 15, Issue 2 (8-2024)
Abstract
Background and Aim: Skin cancer is one of the most common cancers. Numerous studies have shown the positive effect of using sunscreen creams in preventing skin cancer. The purpose of this study was to determine the inequality in the use of sunscreen cream.
Methods: This cross-sectional study was conducted among adults in Kermanshah city. Data was collected using questionnaire by interview. Concentration index and curve were used to quantify and analyze inequality in sunscreen use. The results of adjusted odds ratio and decomposition analysis for sunscreen use were also estimated.
Results: 14.39% used sunscreen. The ratio of use in men was 5.65% and in women was 21.72%. The concentration index for sunscreen use (P<0.001) was 0.344, which indicates the greater concentration of sunscreen use among the rich. The rich groups are 3.72 times more likely to use sunscreen than the poor, and people in the middle class are also 1.48 times more likely to use sunscreen. The highest share of participation in the creation of inequality in sunscreen consumption was achieved by the socio-economic status variable with 61.26%, education level with 13.23% and age with 13.02%.
Conclusion: The focus of health promotion interventions should target groups with low socio-economic status. Men and less educated people should be prioritized in the development and implementation of interventions.
Tayebeh Momeni, Alieh Safamanesh, Faezeh Kashanian,
Volume 15, Issue 2 (8-2024)
Abstract
Curcuma zedoaria, an aromatic plant from the ginger family, has gained attention for its medicinal properties. In traditional medicine, Curcuma zedoaria has been used as an anti-inflammatory, antibacterial, antifungal, and analgesic. Recent scientific research has revealed significant benefits of Curcuma zedoaria for skin health. Curcuma zedoaria contains curcumin, a powerful anti-inflammatory compound that can help reduce skin inflammation, redness, and swelling. This makes Curcuma zedoaria a suitable option for treating acne, eczema, and psoriasis. Curcumin in Curcuma zedoaria also possesses strong antioxidant properties that can help protect the skin from damage caused by free radicals. Additionally, curcumin can promote collagen and elastin production, which are essential for wound healing. The antimicrobial properties of curcumin can aid in combating bacteria and fungi that cause skin infections. Curcuma zedoaria also exhibits anticancer properties that can help prevent the growth of skin cancer cells. Therefore, Curcuma zedoaria is a natural and safe plant that can help treat a wide range of skin problems. This review article explores the various benefits of Curcuma zedoaria for the skin.
Ala Ehsani, Seyedamirmohamad Rezaei Majd, Amirhoushang Ehsani, Pedram Nourmohammadpour, Mina Koohian Mohammadabadi, Zahra Razavi, Mahshid-Ol-Sadat Ansari, Reyhaneh Seyf, Amirhossein Rahimnia,
Volume 15, Issue 3 (11-2024)
Abstract
Background and aim: Pityriasis lichenoides (PL) is a rare papulosquamous disorder with an unknown etiology. Due to limited recent studies on this subject, the present research was conducted to describe the clinical manifestations and treatment course of these patients.
Methods: This retrospective cross-sectional study (2019-2023) was conducted on patients diagnosed with PL at Razi Dermatology Hospital, Tehran University of Medical Sciences, Iran confirmed by biopsy of skin lesions. Basic information was obtained from hospital records, and treatment follow-up was gathered from medical files and phone interviews with patients. Data were analyzed using R software, with a P<0.05 considered statistically significant.
Results: A total of 147 patients were evaluated. No significant difference was found between genders (P=0.358). The predominant subtype was PLC (91.8%), with a mean age of onset of 29.79 ± 18.73 years. The most common type of skin lesion was papules (48.4%), and generalized body involvement was the most frequent manifestation, observed in 58 patients (32.4%). The most commonly used treatment was topical corticosteroids, administered to 86 patients (52.4%). The average duration from onset to full recovery was 160.80±221.40 days. A total of 45 patients (30.6%) reported recurrent episodes of the disease. No significant association was found between treatment efficacy and gender (P=0.620), underlying conditions (P=0.293), or age (P=0.876).
Conclusion: Given the limited clinical data on patients with pityriasis lichenoides, establishing an electronic database and a national registry system for this condition is recommended.
Mehdi Mirzaei-Alavijeh, Asad Bohrojeh, Hossein Ashtarian, Behrooz Hamzeh, Farzad Jalilian,
Volume 15, Issue 3 (11-2024)
Abstract
Background and Aim: Skin cancer is the most preventable type of cancer. Farmers, due to their work under the sun's ultraviolet radiation, are at a higher risk of developing skin cancer. The purpose of this study was to determine the determinants of skin cancer prevention behaviors in farmers.
Methods: This cross-sectional study was conducted among farmers in the rural of Javanroud city in the west of Iran. Information was collected by questionnaire and interview. Data were analyzed in SPSS version 16 statistical software. Crude and adjusted linear regression was used to measure the determinants of skin cancer prevention behaviors.
Results: The mean age of the participants was 36.47 years. Perceived self-efficacy (ß=0.193, P=0.004) and response costs (ß=0.145, P=0.025) were the most important influencing determinants on skin cancer prevention behaviors.
Conclusion: It seems that if the development of interventions to promote skin cancer prevention behaviors among farmers focuses on promoting perceived self-efficacy and reducing response costs, it can seek useful findings in promoting skin cancer prevention behaviors.
Ala Ehsani, Bahar Sadeghi, Amirhoushang Ehsani, Mahshid-Ol- Sadat Ansari, Zahra Razavi, Mina Koohian Mohammadabadi, Kambiz Kamyab, Pedram Nourmohammadpour, Mobina Kamalabadi Farahani, Amirhossein Rahimnia,
Volume 15, Issue 3 (11-2024)
Abstract
Background and Aim: Angiokeratomas are rare vascular lesions, typically presenting as small red to purple macules or papules on the skin. These lesions are usually benign, though they can undergo changes in thickness and color over time. Certain types of angiokeratomas may also signal underlying metabolic disorders, necessitating careful clinical attention. This study aims to analyze the clinical and demographic features of angiokeratoma in Iranian patients at Razi Dermatology Hospital.
Methods: This descriptive, retrospective cross-sectional study examined 199 patients diagnosed with angiokeratoma between 2013 and 2023. Data on demographics, lesion characteristics (location and size), family history, and treatment methods were collected from medical records and analyzed using SPSS. Both parametric and non-parametric statistical tests were applied to assess associations, with a significance level set at 0.05.
Results: The mean age of patients was 24.75 years, with the second and third decades showing the highest prevalence. Among the patients, 51.3% were male and 48.7% female. Lesions most commonly appeared on the lower extremities (40.7%) and genital area (18.6%). Treatment methods included cryotherapy (68.14%), laser (27.14%), and electrodessication (4.44%), with cryotherapy proving the most effective among them.
Conclusion: This study provides valuable insights into the prevalence, clinical characteristics, and preferred treatment approaches for angiokeratoma in Iranian patients. Broader studies across various centers, along with long-term follow-up, are recommended to further investigate the clinical course, therapeutic outcomes, and potential complications associated with different treatment methods.
Elham Rezayi Jarihani, Nahid Hassanzadeh Nemati,
Volume 15, Issue 3 (11-2024)
Abstract
Aging and wrinkles on the face and neck are natural processes throughout a person's life. On these days, there are various techniques to treat these facial lines. The non-invasive facelift technique is suggested considering the risks and effects of different cosmetic procedures. This research collected information about using polymer threads for lifting the face and treating ptosis from authentic scientific texts published in databases such as PubMed, Google Scholar, Science Direct, and Web of Science. The investigations showed that when placed correctly, biodegradable polymer threads cause skin irritation and promote collagen formation, so that’s interesting for patients and doctors. Patients undergoing a facelift with polymer threads experience fewer complications than those undergoing traditional methods. Despite the low side effects of this method, some patients have opted to remove the threads after the lift due to dissatisfaction with their appearance. Threads with superficial spines and biodegradability are considered popular and attractive for lifting the soft tissue of the face due to their quick recovery and low cost. Different types of absorbable threads are available in the market, each with different compositions and have different designs depending on the place of use. This review study will discuss biodegradable polydioxanone (PDO), polycaprolactone (PCL), and polylactic acid (PLLA) yarns.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (11-2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
Fatemeh Torkashvand, Abdolah Chalechale, Sina Vafi,
Volume 15, Issue 4 (2-2025)
Abstract
Background and Aim: Image brightness heterogeneity is one of the major challenges in computer image processing that can lead to inaccurate results in image segmentation. Despite the existence of numerous segmentation methods, few studies have been conducted on the effect of brightness heterogeneity and the selection of the best color channels in segmentation. In this paper, different color spaces have been used for automatic detection of skin lesions.
Methods: In this study, the LSE (Level Set Evolution) segmentation method along with intensity smoothing has been used for computer recognition of skin lesions. First, the brightness heterogeneity is reduced and a more uniform image is created. Then, the proposed segmentation divides the image domain into distinct regions. This method results in more accurate recognition of skin lesions.
Results: The proposed method has been tested on 200 dermoscopic images from the known PH2 dataset using different color channels. The results show that this method performs better than other methods. Accuracy of 97%, sensitivity of 98%, specificity of 99% and Dice coefficient of 92% have been obtained.
Conclusion: This method has the ability to accurately isolate and diagnose lesions and can help doctors in the treatment process of skin lesions.
Aref Nassiri Kashani, Tarane Yazdanparast, Fateme Amiri, Mansour Nassiri Kashani, Alireza Firooz, Mahdi Gheisari,
Volume 16, Issue 1 (5-2025)
Abstract
Background and aim: Macular amyloidosis (MA) is a form of primary localized cutaneous amyloidosis (PLCA), characterized by amyloid deposits in the papillary dermis. This study aimed to compare the biophysical properties of MA lesions with those of adjacent uninvolved skin.
Methods: We measured several parameters in active MA lesions of 22 patients, including stratum corneum (SC) hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, and R5), as well as epidermal and dermal thickness and echo-density using ultrasonography. Measurements from the lesions were compared with those from healthy skin adjacent to the lesions, serving as controls. Statistical analysis was performed using the paired t-test, with P-values less than 0.05 considered significant.
Results: Compared to adjacent normal skin, MA lesions demonstrated significantly lower SC hydration and surface friction, while TEWL, pH, erythema index, melanin content, and epidermal thickness were significantly increased. No significant differences were found in sebum levels, temperature, elasticity parameters, or dermal thickness and echo-density.
Conclusion: MA lesions exhibit distinct biophysical and ultrasonographic changes consistent with their histopathological features. These characteristic alterations may serve as useful, non-invasive markers for the early diagnosis of cutaneous macular amyloidosis.
