Showing 28 results for Age
Hasti Ahmadian Yazdi Ahmadian Yazdi, Alireza Firooz, Maryam Movafegh, Faegheh Kazemi, Saman Ahmadnasrollahi, Aniseh Samadi,
Volume 13, Issue 4 (2-2023)
Abstract
Background and Aim: Oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumers. The purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration and roughness.
Methods: It was a 12-week, before-after clinical study, conducted on 20 participants (18 women and two men) aged 44.15±5.36 years with skin type III-IV. Skin elasticity parameters (R0, R2, R5 and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as four weeks after stopping its use (week 16). Participants’ satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.
Results: A significant improvement was detected in R2, R5 and skin friction at week 12 (P<0.041, P<0.012 and P<0.01, respectively). At week 16, the values remained at an increased level, which indicates the stability of the results. The increase of dermis density in week 16 was also significant (P=0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.
Conclusion: The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.
Mahbobeh Dehghan Nayeri, Mohammadhossein Bayazi,
Volume 14, Issue 1 (5-2023)
Abstract
Background and Aim: The purpose of this research was to compare the effectiveness of cognitive behavioral and emotion-focused group therapy on reducing the symptoms of psoriasis, psychological distress and perception of body image.
Methods: This was a semi-experimental research of pretest posttest type with a control group. The statistical population of this research included all patients who were diagnosed with psoriasis in spring of 2022 by referring to dermatologists in Mashhad. 45 psoriasis patients were selected by available sampling method and replaced randomly in two experimental groups (CBT and EFT) and control group (each groups 15). The experimental groups was treated for 8 sessions, one session of 90 minutes per week. The control group received no intervention. Parents completed the Psychological Distress Scale, Body Image Concern Inventory and the Physical Symptoms Questionnaire with Psoriasis Area Severity Index before and after the treatment sessions. The data were analyzed by Analysis of covariance.
Results: The findings showed that cognitive-behavioral and emotion-focused reduced psychological distress (P<0.01, F=21.06), improved perception of body image (P<0.01, F=33.65) and reducing the severity of psoriasis symptoms (P>0.01, F=12.67) are effective. Also, cognitive behavioral therapy is more effective method to reduce psychological distress and improve perception of body image (P<0.01). However, there is no significant difference between the effectiveness of cognitive-behavioral therapy and emotion-focused therapy in reducing psoriasis symptoms of patients (P<0.05).
Conclusion: Both therapies can play a key and effective role in controlling the symptoms of psoriasis.
Hossein Sharifi, Ensieh Lotfali,
Volume 14, Issue 3 (11-2023)
Abstract
Background and Aim: Considering the increase of dermatophytosis trough the Iran and world as well, especially ringworm of the body and groin due to terbinafine-resistant species and the high speed of disease transmission, in order to choose the appropriate treatment, considering the time required for the treatment of the disease and early detection of resistant cases treatment is required. The present study was conducted to determine the antifungal sensitivity of Trichophyton rubrum, Microsporum canis and Epidermophyton flucosum strains to common antifungal drugs.
Methods: Antifungal sensitivity test (broth microdilution) was performed for 20 specimens obtained from patients according to CLSI (Clinical and Laboratory Standard Institute) M38-3rd ED protocol, for terbinafine, itraconazole and voriconazole.
Results: According to the antifungal susceptibility test results, 5 patients were resistant to terbinafine and showed a minimum inhibitory concentration more than 2, 3 patients were tolerant to terbinafine and showed a minimum inhibitory concentration between 0.5 and 1. Based on the results of the antifungal susceptibility test, 7 patients were tolerant to itraconazole and showed the minimum inhibitory concentration between 0.5 and 1. All isolates responded well to voriconazole.
Conclusion: The results of the antifungal sensitivity test highlight the importance of mycological tests on dermatophytic skin lesions to prevent the spread of drug-resistant species.
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (11-2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
Fatemeh Torkashvand, Abdolah Chalechale, Sina Vafi,
Volume 15, Issue 4 (2-2025)
Abstract
Background and Aim: Image brightness heterogeneity is one of the major challenges in computer image processing that can lead to inaccurate results in image segmentation. Despite the existence of numerous segmentation methods, few studies have been conducted on the effect of brightness heterogeneity and the selection of the best color channels in segmentation. In this paper, different color spaces have been used for automatic detection of skin lesions.
Methods: In this study, the LSE (Level Set Evolution) segmentation method along with intensity smoothing has been used for computer recognition of skin lesions. First, the brightness heterogeneity is reduced and a more uniform image is created. Then, the proposed segmentation divides the image domain into distinct regions. This method results in more accurate recognition of skin lesions.
Results: The proposed method has been tested on 200 dermoscopic images from the known PH2 dataset using different color channels. The results show that this method performs better than other methods. Accuracy of 97%, sensitivity of 98%, specificity of 99% and Dice coefficient of 92% have been obtained.
Conclusion: This method has the ability to accurately isolate and diagnose lesions and can help doctors in the treatment process of skin lesions.
Mahmood Araghi, Zahra Oushyani Roudsari, Malihe Naghavi,
Volume 15, Issue 4 (2-2025)
Abstract
Impaired wound healing following significant tissue damage such as severe burns, trauma, or surgery can result in scarring and skin fibrosis. Pathological scarring leads to changes in the natural shape of the wound and, in addition to cosmetic problems, may be accompanied by pain and even limit the person's normal movement. The immune response plays a very important role in the wound healing process. Activation of immune cells and factors initiates the inflammatory process, facilitates wound cleansing, and tissue repair and regeneration. However, disruption of the immune system during the wound healing process leads to persistent inflammation and delayed healing, ultimately leading to the development of chronic wounds. The microenvironment of a chronic wound contains a large number of immune cells, including proinflammatory macrophages, and high expression of inflammatory mediators such as TNF-α and IL-1β is observed in it. Among them, macrophages, as innate immune cells, play a key role in promoting the immune response and activating adaptive immunity. These cells are also key factors in the transition from the inflammatory phase to the tissue repair phase. As a result, dysregulation of macrophage function will have consequences such as scarring. Therefore, knowledge of the exact mechanism of the inflammatory process during wound healing, the inflammatory and anti-inflammatory mediators produced, and the effect of macrophages on this process can promise the achievement of new strategies in scarless wound healing. Therefore, this article discusses the mechanism of the immune system during the inflammatory process, and the key role of macrophages in this process, as well as scar formation.
Faezeh Roshanbakht, Nahid Hassanzadeh Nemati, Neda Attaran Kakhki,
Volume 16, Issue 1 (5-2025)
Abstract
Skin infections caused by pathogenic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa have become a serious challenge in the field of antibacterial therapies, especially in the context of antibiotic resistance. In this regard, the simultaneous use of classical antibiotic combinations with advanced nanostructures is considered a novel and effective approach. Narasin, an ionophore antibiotic of natural origin, has a high potential in inhibiting bacterial growth due to its ability to disrupt cell membrane function and ion transport. On the other hand, silica nanostructures, especially mesoporous silica nanoparticles, play an important role in enhancing antibacterial activity due to their properties such as biocompatibility, drug loading capability, controlled release, and production of reactive oxygen species.
Recent studies have shown that the combination of narasin with silica nanostructures enhances the synergistic antibacterial effects, increases drug stability, and improves penetration into bacterial biofilms. This combination has also been effective in reducing the dosage and systemic toxicity. Despite promising results in laboratory and animal models, challenges such as the assessment of cytotoxicity, precise release control, and the need for extensive clinical studies remain.
In this article, while comprehensively reviewing the properties and functions of narasin and silica nanostructures, the mechanisms of their combined effects on skin pathogenic bacteria are discussed and future prospects in the development of nanobiotechnological therapies are reviewed.
Azin Ayatollahi,
Volume 16, Issue 2 (7-2025)
Abstract
Human lip aging is one of the natural signs of the body’s aging process, occurring over time due to factors such as a decrease in collagen and elastin, exposure to sunlight, environmental stress, and genetic changes. As time passes, the lips may lose their appearance, and fine lines or deep wrinkles may form around the lips and the upper lip area. These changes can lead to a reduction in lip volume and the loss of their natural shape. Additionally, dryness and chapping of the lips are other issues commonly observed with lip aging. Skin care, the use of moisturizers, and avoiding prolonged sun exposure can help slow down this process.
