Showing 27 results for Nassiri Kashani
Erfan Zamani, Shayan Zamani, Mansour Nassiri Kashani, Alireza Firooz,
Volume 15, Issue 3 (Volume 15, No3 2024)
Abstract
This review study examines the effects of oral collagen supplementation on various biophysical properties of the skin, including hydration, elasticity, and wrinkle reduction. Collagen, as the most abundant structural protein in the skin, plays a vital role in maintaining its firmness, elasticity, and moisture. With aging, collagen production declines, leading to visible signs of aging such as wrinkles, sagging, and dryness of the skin. Additionally, factors like UV radiation and environmental pollutants accelerate collagen degradation, contributing to premature skin aging. In recent years, oral supplements containing hydrolyzed collagen, particularly collagen peptides, have gained significant popularity due to their potential ability to stimulate collagen production and improve skin quality. Various studies indicate that regular consumption of these supplements can significantly increase skin hydration, enhance elasticity, and reduce the depth and number of wrinkles. However, there are notable limitations in the existing studies, including variations in dosage, intervention duration, and collagen sources. Moreover, many of these studies have small sample sizes and short intervention periods, which limit the validity of the results. Additionally, the presence of other ingredients, such as vitamin C and hyaluronic acid in some supplements, makes it challenging to isolate the direct effects of collagen. Despite these challenges, the existing evidence suggests that oral collagen supplementation holds high potential as an effective approach for addressing skin aging. However, further long-term studies with larger sample sizes and more diverse populations are necessary to determine the precise mechanisms and optimal dosage, thereby providing more definitive scientific recommendations.
Mansour Nassiri Kashani,
Volume 15, Issue 4 (Volume 15, No 4 2025)
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Mansour Nassiri Kashani,
Volume 16, Issue 1 (Volume 16, No 1 2025)
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Aref Nassiri Kashani, Tarane Yazdanparast, Fateme Amiri, Mansour Nassiri Kashani, Alireza Firooz, Mahdi Gheisari,
Volume 16, Issue 1 (Volume 16, No 1 2025)
Abstract
Background and aim: Macular amyloidosis (MA) is a form of primary localized cutaneous amyloidosis (PLCA), characterized by amyloid deposits in the papillary dermis. This study aimed to compare the biophysical properties of MA lesions with those of adjacent uninvolved skin.
Methods: We measured several parameters in active MA lesions of 22 patients, including stratum corneum (SC) hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, and R5), as well as epidermal and dermal thickness and echo-density using ultrasonography. Measurements from the lesions were compared with those from healthy skin adjacent to the lesions, serving as controls. Statistical analysis was performed using the paired t-test, with P-values less than 0.05 considered significant.
Results: Compared to adjacent normal skin, MA lesions demonstrated significantly lower SC hydration and surface friction, while TEWL, pH, erythema index, melanin content, and epidermal thickness were significantly increased. No significant differences were found in sebum levels, temperature, elasticity parameters, or dermal thickness and echo-density.
Conclusion: MA lesions exhibit distinct biophysical and ultrasonographic changes consistent with their histopathological features. These characteristic alterations may serve as useful, non-invasive markers for the early diagnosis of cutaneous macular amyloidosis.
Mansour Nassiri Kashani,
Volume 16, Issue 2 (Volume 16, No 2 2025)
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Mansour Nassiri Kashani,
Volume 16, Issue 3 (Volume 16, No 3 2025)
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Aniseh Samadi, Mansour Nassiri Kashani, Azin Ayatollahi, Hamed Zartab, Maryam Ahmadi, Alireza Firooz,
Volume 16, Issue 3 (Volume 16, No 3 2025)
Abstract
Background and aim: In recent years, increasing demand for aesthetic treatments in Iran and the need for high-quality domestic products have encouraged several companies to produce botulinum toxin type A. This study aimed to evaluate and compare the clinical efficacy and safety of three such Iranian products.
Methods: In the first part of the study, the overall efficacy of the botulinum toxin type A products for treating glabellar lines was assessed in 230 participants who received one of the three Iranian formulations (mean age 42.69 ± 9.21 years), and compared with 230 participants who received the standard treatment (Dysport®) (mean age 42.50±9.79 years). Outcomes were evaluated on day 30 post-injection. In the second part, the comparative efficacy of the three domestic products during the same period and their safety profile up to month four post-injection were assessed.
Results: A clinically meaningful response (at least a two-grade improvement in glabellar line severity) was achieved in 68.6% of recipients of the Iranian products, compared with 52.8% of Dysport recipients, demonstrating a statistically significant superiority in equivalence studies (P<0.01). Among the three domestic products, only product No. 2 showed a significantly higher proportion of participants achieving ≥2-grade improvement (assessed by an independent physician). The type and frequency of adverse events (except for headache) were comparable to the standard drug monograph.
Conclusion: The findings indicate acceptable efficacy and safety of Iran-made botulinum toxin type A products compared with the reference product. Except for limited differences, the efficacy and safety profiles of the three formulations were generally similar up to day 30 post-injection.
